Effect of Crude Ethanol Leaf-extract of Murraya koenigii on Anxiety in Mice

Bisong, Sunday Agba; Okon, Udemeobong; G.E, Egbung; Abuo, Favour E.; Sanya, Olurotimi J

doi:10.9734/ajmah/2017/36294

Cited by 4 publications

(3 citation statements)

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“…The elevated plus maze as described by Lister [17] and used by Bisong et al [18,19] was employed in this study. The apparatus has 2 open arms (each measuring 30x5x15cm) and two closed arms (each measuring 30x5x15cm) extending from a central, open square (5x5cm).…”

Section: Methodsmentioning

confidence: 99%

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Long-term Consumption of Kola-nut (Cola nitida) Diet Does Not Increase Anxiety Related Behaviour in Mice

Bisong

Nku

et al. 2019

AJRIMPS

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Following long-term consumption of kola nut (Cola nitida) diet, anxiety related behaviour were studied in 16 Swiss white mice (18-28g body weight). The open field (OF) test, elevated plus maze EPM) and the light/light transition box (LD) tests were used. Swiss white mice were fed either control diet (rodent chow; n=8) or kola nut diet (50% w/w kola-nut diet; n=8) for 28 days. All animals were allowed free access to clean drinking water. Results showed that the frequency of rearing in the kola nut diet group was lower (p< 0.05) compared to control. The non-exploratory behaviours like grooming and genital licking were also lower in the test group compared to control (p<0.001, 0.05 respectively). In the EPM test, the duration in the open arm in the kola diet group was higher compared to control (p< 0.01). The duration of grooming in the test group was however higher in the closed arm compared with control (p< 0.01). The frequency of downward dips only correlated positively with the duration in the open arm in the control [r (16) = 0.855; p< 0.01]. The AJRIMPS, 6(1): 1-8, 2019; Article no.AJRIMPS.45797 2 kola fed animals spent more time in the light region of the LD test (p< 0.01) rearing and walling (p<0.05), and spent less time in the dark region when compared with their control. In conclusion, long-term consumption of kola nut diet decreased anxiety-related behaviour in the mice. Original Research Article

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Section: Methodsmentioning

confidence: 99%

“…The light/dark transition box test as described by Hascoët and Bourini [20] and used by Bisong et al [18] was used. It is box measuring 46x30x27cm high (l x b x h cm), divided into two compartments; a small 18x30cm area and a large 27x30cm area with a 7x7cm door on floor of the partition linking the two chambers.…”

Section: Methodsmentioning

confidence: 99%

Long-term Consumption of Kola-nut (Cola nitida) Diet Does Not Increase Anxiety Related Behaviour in Mice

Bisong

Nku

et al. 2019

AJRIMPS

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“…Additionally, o‐methylmurrayamine A, mukolidine and murrayakonine A were able to inhibit the release of IL‐6, TNF‐α in LPS‐induced inflammation [73] . The pharmacological activities of various extract on M. koenigii (L.) Spreng are discussed in Table 4 [39,45–46,58,62,69–70,74–149] and Figure 5 along with various patents on M. koenigii (L.) Spreng showed in Table 5 [150–157]…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Phyto‐Pharmacological Review onMurraya koenigii(L.) Spreng: As an Indigenous Plant of India with High Medicinal Potential

Singh

Ahuja

Murti

et al. 2023

Chemistry & Biodiversity

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The medicinal aspects of Murraya koenigii (L.) Spreng. It also provides the latest updated information on pharmacological and plant patents on phytoconstituents. The information was collected from various sources, including literature surveys, textbooks, databases, and internet sources like Scopus, Science Direct, Pubmed, Springer, Google Scholar, Taylor and Francis. The plant, Murraya koenigii (L.) Spreng is an extensive valuable, and important medicinal plant in the Indian System of Medicine. The plant proved to show various ethnomedicinal uses mentioned in the literature and even possessed various pharmacological activities. Different bioactive metabolites exhibit several biological activities. However, the biological efficacies of various other chemical constituents are yet to be clarified and proved concerning the molecular mechanisms.

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Murraya koenigii (L.) Spreng: Speculative ethnobotanical perspectives of ubiquitous herb with versatile nutra/functional properties

Suthar

Kumar

et al. 2022

South African Journal of Botany

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Effect of Crude Ethanol Leaf-extract of Murraya koenigii on Anxiety in Mice

Cited by 4 publications

References 0 publications

Long-term Consumption of Kola-nut (Cola nitida) Diet Does Not Increase Anxiety Related Behaviour in Mice

Long-term Consumption of Kola-nut (Cola nitida) Diet Does Not Increase Anxiety Related Behaviour in Mice

Phyto‐Pharmacological Review onMurraya koenigii(L.) Spreng: As an Indigenous Plant of India with High Medicinal Potential

Murraya koenigii (L.) Spreng: Speculative ethnobotanical perspectives of ubiquitous herb with versatile nutra/functional properties

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