Effect of crystal form, cortisone alcohol and agitation on crystal growth of cortisone acetate in aqueous suspensions

Abstract

Particle size distribution in aqueous suspensions of stable and unstable crystal forms of cortisone acetate under conditions of agitation and different degrees of saturation with cortisone alcohol is described. Agitation accelerated the diffusion-controlled processes of dissolution and crystallization, leading to the formation of a high proportion of large particles. Cortisone alcohol inhibited the polymorphic transformation necessary for the crystal growth and formation of the water-stable form. The mechanism of action is discussed.

Facial Blanching After Cutaneous Injections: Cannulation of Branches of the Ophthalmic Artery. Case Series and Review of the Literature

“…The mechanism behind blindness secondary to arterial injection of steroids is most likely due to embolism of undissolved steroid crystals in suspension, especially in steroid preparations that have been stored for long periods of time 22,23 . For triamcinolone preparations, particles with diameter of 0.5 to more than 100 μm have been reported, with the largest particles more than 12 times the size of red blood cells 24 .…”