Effect of Cucumis sativus on Dysfunctional 3T3-L1 Adipocytes

Méndez-Martínez, Marisol; Trejo-Moreno, Celeste; Laura, Maldonado-Mejía; Fernando, Esquivel-Guadarrama; Pedraza-Chaverri, José; Zamilpa, Alejandro; Omar, Medina-Campos; Francisco, A.M.L. de; César, Almanza-Pérez Julio; Contreras-Nuñez, Erika; Angélica, Santana-Calderón; Fragoso, Gladis; Enrique, Jiménez-Ferrer; Rosas, Gabriela

doi:10.1038/s41598-019-49458-6

Cited by 8 publications

(6 citation statements)

References 54 publications

(79 reference statements)

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“…Cucumber does not belong to the Brassicacea family but did however show a protective effect. Although less well studied, cucumber acts as an antioxidant on insulin resistance and its related diseases 22-24 . Cucurbitacin B, a natural compound that exists in edible plants (bitter melons, cucumbers, pumpkins and zucchini), has anti-inflammatory and hypoglycemic properties through the activation of Nrf2 25,26 .…”

Section: Discussionmentioning

confidence: 99%

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Association between consumption of vegetables and COVID-19 mortality at a country level in Europe

Fonseca

Rivas

Romaguera

et al. 2020

Preprint

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Background Many foods have an antioxidant activity, and nutrition may mitigate COVID-19. To test the potential role of vegetables in COVID-19 mortality in Europe, we performed an ecological study. Methods The European Food Safety Authority (EFSA) Comprehensive European Food Consumption Database was used to study the country consumption of Brassica vegetables (broccoli, cauliflower, head cabbage (white, red and savoy cabbage), leafy brassica) and to compare them with spinach, cucumber, courgette, lettuce and tomato. The COVID-19 mortality per number of inhabitants was obtained from the Johns Hopkins Coronavirus Resource Center. EuroStat data were used for potential confounders at the country level including Gross Domestic Product (GDP) (2019), population density (2018), percentage of people over 64 years (2019), unemployment rate (2019) and percentage of obesity (2014, to avoid missing values). Mortality counts were analyzed with quasi-Poisson regression models to model the death rate while accounting for over-dispersion. Results Of all the variables considered, including confounders, only head cabbage and cucumber reached statistical significance with the COVID-19 death rate per country. For each g/day increase in the average national consumption of some of the vegetables (head cabbage and cucumber), the mortality risk for COVID-19 decreased by a factor of 11, down to 13.6 %. Lettuce consumption increased COVID-19 mortality. The adjustment did not change the point estimate and the results were still significant. Discussion The negative ecological association between COVID-19 mortality and the consumption of cabbage and cucumber supports the a priori hypothesis previously reported. The hypothesis needs to be tested in individual studies performed in countries where the consumption of vegetables is common.

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Section: Discussionmentioning

confidence: 99%

“…Cruciferous vegetables like Brassicaceae contain high amounts of sulforaphane, a potent activator of Nfr2 16 . However, broccoli [17][18][19] and cauliflower 20 [22][23][24] . Cucurbitacin B, a natural compound that exists in edible plants (bitter melons, cucumbers, pumpkins and zucchini), has anti-inflammatory and hypoglycemic…”

mentioning

confidence: 99%

Association between consumption of vegetables and COVID-19 mortality at a country level in Europe

Fonseca

Rivas

Romaguera

et al. 2020

Preprint

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“…Nitrogen was employed both as a desolvation gas and cone gas. An MS scan was performed using argon gas as the collision gas [ 45 ].…”

Section: Methodsmentioning

confidence: 99%

Synergism and Subadditivity of Verbascoside-Lignans and -Iridoids Binary Mixtures Isolated from Castilleja tenuiflora Benth. on NF-κB/AP-1 Inhibition Activity

et al. 2021

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Pharmacodynamic interactions between plant isolated compounds are important to understand the mode of action of an herbal extract to formulate or create better standardized extracts, phytomedicines, or phytopharmaceuticals. In this work, we propose binary mixtures using a leader compound to found pharmacodynamic interactions in inhibition of the NF-κB/AP-1 pathway using RAW-Blue™ cells. Eight compounds were isolated from Castilleja tenuiflora, four were new furofuran-type lignans for the species magnolin, eudesmin, sesamin, and kobusin. Magnolin (60.97%) was the most effective lignan inhibiting the NF-κB/AP-1 pathway, followed by eudesmin (56.82%), tenuifloroside (52.91%), sesamin (52.63%), and kobusin (45.45%). Verbascoside, a major compound contained in wild C. tenuiflora showed an inhibitory effect on NF-κB/AP-1. This polyphenol was chosen as a leader compound for binary mixtures. Verbacoside-aucubin and verbascoside-kobusin produced synergism, while verbascoside-tenuifloroside had subadditivity in all concentrations. Verbascoside-kobusin is a promising mixture to use on NF-κB/AP-1 related diseases and anti-inflammatory C. tenuiflora-based phytomedicines.

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“…Under chronic obese condition, increased free fatty acids induce cellular oxidative stress in adipose tissue through the production of reactive oxygen species (ROS), which trigger adipocyte dysfunction and induce production of pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β from adipose tissue, consequentially potentiating adipose tissue inflammation and obesity-related diseases such as T2DM [ 6 ]. Adipose dysfunction in obesity also potentiates insulin resistance and triglyceride storage impairment.…”

Section: Introductionmentioning

confidence: 99%

Vindoline Exhibits Anti-Diabetic Potential in Insulin-Resistant 3T3-L1 Adipocytes and L6 Skeletal Myoblasts

Shijina,

Radhika,

Sherin

et al. 2023

Nutrients

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Type 2 diabetes mellitus (T2DM) emerged as a major health care concern in modern society, primarily due to lifestyle changes and dietary habits. Obesity-induced insulin resistance is considered as the major pathogenic factor in T2DM. In this study, we investigated the effect of vindoline, an indole alkaloid of Catharanthus roseus on insulin resistance (IR), oxidative stress and inflammatory responses in dexamethasone (IR inducer)-induced dysfunctional 3T3-L1 adipocytes and high-glucose-induced insulin-resistant L6-myoblast cells. Results showed that dexamethasone-induced dysfunctional 3T3-L1 adipocytes treated with different concentrations of vindoline significantly enhanced basal glucose consumption, accompanied by increased expression of GLUT-4, IRS-1 and adiponectin. Similarly, vindoline-treated insulin-resistant L6 myoblasts exhibited significantly enhanced glycogen content accompanied with upregulation of IRS-1 and GLUT-4. Thus, in vitro studies of vindoline in insulin resistant skeleton muscle and dysfunctional adipocytes confirmed that vindoline treatment significantly mitigated insulin resistance in myotubes and improved functional status of adipocytes. These results demonstrated that vindoline has the potential to be used as a therapeutic agent to ameliorate obesity-induced T2DM-associated insulin resistance profile in adipocytes and skeletal muscles.

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Effect of Cucumis sativus on Dysfunctional 3T3-L1 Adipocytes

Cited by 8 publications

References 54 publications

Association between consumption of vegetables and COVID-19 mortality at a country level in Europe

Association between consumption of vegetables and COVID-19 mortality at a country level in Europe

Synergism and Subadditivity of Verbascoside-Lignans and -Iridoids Binary Mixtures Isolated from Castilleja tenuiflora Benth. on NF-κB/AP-1 Inhibition Activity

Vindoline Exhibits Anti-Diabetic Potential in Insulin-Resistant 3T3-L1 Adipocytes and L6 Skeletal Myoblasts

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