Effect of cumin (Cuminum cyminum) seed essential oil on biofilm formation and plasmid Integrity ofKlebsiellapneumoniae

Derakhshan, Safoura; Sattari, Morteza; Bigdeli, Mohsen

doi:10.4103/0973-1296.59967

Cited by 63 publications

(17 citation statements)

References 17 publications

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“…It was previously reported that the essential oil of C. cyminum seeds reduces Streptococcus mutans and S. pyogenes biofilm formation [47]. Similar effects were observed for sub-inhibitory concentrations of the essential oil when assessed against Klebsiella pneumoniae [48]. Recently, cuminaldehyde was shown to impair biofilm formation by E. coli [32].…”

Section: Plos Onementioning

confidence: 53%

Cuminaldehyde potentiates the antimicrobial actions of ciprofloxacin against Staphylococcus aureus and Escherichia coli

et al. 2020

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Escherichia coli and Staphylococcus aureus are important agents of urinary tract infections that can often evolve to severe infections. The rise of antibiotic-resistant strains has driven the search for novel therapies to replace the use or act as adjuvants of antibiotics. In this context, plant-derived compounds have been widely investigated. Cuminaldehyde is suggested as the major antimicrobial compound of the cumin seed essential oil. However, this effect is not fully understood. Herein, we investigated the in silico and in vitro activities of cuminaldehyde, as well as its ability to potentiate ciprofloxacin effects against S. aureus and E. coli. In silico analyses were performed by using different computational tools. The PASS online and SwissADME programmes were used for the prediction of biological activities and oral bioavailability of cuminaldehyde. For analysis of the possible toxic effects and the theoretical pharmacokinetic parameters of the compound, the Osiris, SwissADME and PROTOX programmes were used. Estimations of cuminaldehyde gastrointestinal absorption, blood brain barrier permeability and skin permeation by using SwissADME; and drug likeness and score by using Osiris, were also evaluated The in vitro antimicrobial effects of cuminaldehyde were determined by using microdilution, biofilm formation and time-kill assays. In silico analysis indicated that cuminaldehyde may act as an antimicrobial and as a membrane permeability enhancer. It was suggested to be highly absorbable by the gastrointestinal tract and likely to cross the blood brain barrier. Also, irritative and harmful effects were predicted for cuminaldehyde if swallowed at its LD50. Good oral bioavailability and drug score were also found for this compound. Cuminaldehyde presented antimicrobial and anti-biofilm effects against S. aureus and E. coli.. When co-incubated with ciprofloxacin, it enhanced the antibiotic antimicrobial and anti-biofilm actions. We suggest that cuminaldehyde may be useful as an adjuvant therapy to ciprofloxacin in S. aureus and E. coli-induced infections.

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Section: Plos Onementioning

confidence: 53%

Cuminaldehyde potentiates the antimicrobial actions of ciprofloxacin against Staphylococcus aureus and Escherichia coli

et al. 2020

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“…Essential oils are volatile compounds with antimicrobial properties constituting non-supportive media for the growth of many bacteria and fungi [ 11 ]. Medicinal plants are considered as potential sources of new chemotherapeutic drugs because of their diverse and non- toxic effect [ 12 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of essential oil (blended and single essential oils) on anti-biofilm formation of Salmonella and Escherichia coli

Wang

Lee

et al. 2017

J Anim Sci Technol

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BackgroundBiofilms were the third-dimensional structure in the solid surface of bacteria. Bacterial biofilms were difficult to control by host defenses and antibiotic therapies. Escherichia coli (E. coli) and Salmonella were popular pathogenic bacteria that live in human and animal intestines. Essential oils are aromatic oily liquids from plant materials and well known for their antibacterial activities.MethodThis study was conducted to determine effect of essential oil on anti-biological biofilm formation of E. coli and Salmonella strains in in vitro experiment. Two kinds of bacterial strains were separated from 0.2 g pig feces. Bacterial strains were distributed in 24 plates per treatment and each plates as a replication. The sample was coated with a Bacterial biofilm formation was.ResultPhotographic result, Escherichia coli (E. coli) and Salmonella bacteria colony surface were thick smooth surface in control. However, colony surface in blended and single essential oil treatment has shown crack surface layer compared with colony surfaces in control.ConclusionIn conclusion, this study could confirm that essential oils have some interesting effect on anti-biofilm formation of E. coli and Salmonella strains from pig feces.

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“…For example, Derakhshan et al were the only group to show that essential oil from cumin seeds reduced biofilm formation in K. pneumoniae . From scanning electron microscopy images, it was evident that the capsular layer of K. pneumoniae was affected, possibly accounting for the observed two-fold decrease in biofilm formation [139]. However, there was no direct evidence to show that this reduction was mediated via quorum sensing pathways (although it is known that quorum sensing regulates the biofilm formation phenotype in the bacteria).…”

Section: Quorum Sensing Disruption Strategies In Gram-negative Bacmentioning

confidence: 99%

Development of Quorum-Based Anti-Virulence Therapeutics Targeting Gram-Negative Bacterial Pathogens

Tay

Yew

2013

IJMS

109

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Quorum sensing is a cell density-dependent signaling phenomenon used by bacteria for coordination of population-wide phenotypes, such as expression of virulence genes, antibiotic resistance and biofilm formation. Lately, disruption of bacterial communication has emerged as an anti-virulence strategy with enormous therapeutic potential given the increasing incidences of drug resistance in pathogenic bacteria. The quorum quenching therapeutic approach promises a lower risk of resistance development, since interference with virulence generally does not affect the growth and fitness of the bacteria and, hence, does not exert an associated selection pressure for drug-resistant strains. With better understanding of bacterial communication networks and mechanisms, many quorum quenching methods have been developed against various clinically significant bacterial pathogens. In particular, Gram-negative bacteria are an important group of pathogens, because, collectively, they are responsible for the majority of hospital-acquired infections. Here, we discuss the current understanding of existing quorum sensing mechanisms and present important inhibitory strategies that have been developed against this group of pathogenic bacteria.

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Effect of cumin (Cuminum cyminum) seed essential oil on biofilm formation and plasmid Integrity ofKlebsiellapneumoniae

Cited by 63 publications

References 17 publications

Cuminaldehyde potentiates the antimicrobial actions of ciprofloxacin against Staphylococcus aureus and Escherichia coli

Cuminaldehyde potentiates the antimicrobial actions of ciprofloxacin against Staphylococcus aureus and Escherichia coli

Effects of essential oil (blended and single essential oils) on anti-biofilm formation of Salmonella and Escherichia coli

Development of Quorum-Based Anti-Virulence Therapeutics Targeting Gram-Negative Bacterial Pathogens

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