Effect of Curcumin and Curcumin Copper Complex (1:1) on Radiation-induced Changes of Anti-oxidant Enzymes Levels in the Livers of Swiss Albino Mice

Abstract

The effect of mononuclear copper (II) complex of curcumin in 1:1 stoichiometry (hereafter referred to as complex) administered 30 min before gamma-irradiation (4.5 Gy) on alterations in antioxidant and Thiobarbituric acid reactive substances (TBARS) levels in livers was studied in comparison to curcumin at a dose of 50 mg/kg. The different antioxidants like GSH, GST, catalase, SOD, TBARS and total thiols were estimated in the liver homogenates excised at different time intervals (1, 2 and 4 h) post irradiation using colorimetric methods. There was a radiation-induced decrease in the levels of all the studied enzymes at 1 h post irradiation, while an increase was observed at later time points. Both curcumin and complex treatment in sham-irradiated mice decreased the levels of GSH and total thiols, whereas there was an increase in the levels of catalase, GST and SOD compared to normal control. Under the influence of irradiation, both curcumin and complex treatment protected the decline in the levels of GSH, GST, SOD, catalase and total thiols, and inhibited radiation-induced lipid peroxidation. Further, the complex was found to be more effective in protecting the enzymes at 1 h post irradiation compared to curcumin treated group. This may be due to the higher rate constants of the complex compared to curcumin for their reactions with various free radicals.

Suppression of Neuroinflammatory and Apoptotic Signaling Cascade by Curcumin Alone and in Combination with Piperine in Rat Model of Olfactory Bulbectomy Induced Depression

“…Similarly, in the present study OBX animals also showed a significant increase in lipid peroxidation and a marked decrease in the activity of reduced glutathione and catalase enzyme. Curcumin attenuated lipid peroxidation [47] and restored endogenous antioxidant profile [48] showing its powerful radical scavenging property [49]. In this study, OBX rats showed a significant increase in nitrite levels thereby implicating endogenous brain nitric oxide in the neurobiology of depression [50].…”

Quantum chemical insights into Alzheimer's disease: Curcumin's chelation with Cu(II), Zn(II), and Pd(II) as a mechanism for its prevention

“…Transition metal ions such as Cu(II), Zn(II), and Pd(II), have been established as one of the causes of Alzheimer's disease . A primary mechanism is their ability to catalyze polymerization of amyloid‐β and promote further misfolding of amyloid‐β into neurotoxic conformations found in brain cell plaques.…”

“…A primary mechanism is their ability to catalyze polymerization of amyloid‐β and promote further misfolding of amyloid‐β into neurotoxic conformations found in brain cell plaques. Curcumin appears to be a promising candidate as a chelating agent in scavenging these neurotoxic transition metal ions through a competitive chelate complexation mechanism . Moreover, curcumin prevents further misfolding of amyloid‐β into neurotoxic conformations that have been isolated in plaques of brain cells .…”

“…Moreover, metal complexes of curcumin, especially those of ruthenium, palladium, copper, zinc and group(13) elements (Al, Ga, In) exhibit anticancer activity, and thus these metal complexes with curcumin appear to be promising candidates for treatment of certain forms of cancer such as lung cancer cells . Consequently, a number of experimental and a few theoretical studies have been devoted to the study of curcumin's chelation complexes with transition metal ions …”

Kinetics and Mechanism of the Thermal and Hydrolytic Decomposition Reaction of Rosocyanin

“…However, many recent studies show that the keto–enol moiety made unreactive by coordination with metal or other groups also show pharmacological properties of the order of curcumin or more . Curcumin coordinates with boron to form a 2:1 tetrahedral complex, rosocyanin (Fig.…”