Effect of curcumin and quercetin on lysosomal enzyme activities in streptozotocin-induced diabetic rats

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

“…The same route of administration has also been reported to improve insulin sensitivity (Murugan and Pari, 2007b). In an STZ-induced diabetic rat model (Chougala et al, 2012), it was observed that dietary curcumin (0.5% in diet) was effective in reducing the increased levels of fasting blood glucose, urine sugar, and urine volume.…”

“…It can also inhibit nuclear factor-kappa B (NF-ߢB) activation (Soetikno et al, 2011), lipid peroxidation (El-Azab et al, 2011 and protein carbonyl content (Suryanarayana et al, 2007). Lysosomal enzyme activities were also inhibited by curcumin (Chougala et al, 2012).…”

Curcumin and Diabetes: A Systematic Review

“…In high fat diet (HFD) induced insulin resistance and type 2 diabetes models in rats, oral administration of curcumin (80 mg/kg·BW) for 15 and 60 days, respectively, showed an antihyperglycemic effect and improved insulin sensitivity [26]. Dietary curcumin (0.5% in diet) was also effective in ameliorating the increased levels of fasting blood glucose, urine sugar, and urine volume in STZ-induced diabetic rats [27]. …”

“…First, curcumin could attenuate tumor necrosis factor- α (TNF- α ) levels [32] and plasma free fatty acids (FFA) [26]. It also inhibits nuclear factor-kappa B (NF- κ B) activation [21] and protein carbonyl [34], lipid peroxidation [32], and lysosomal enzyme activities (N-acetyl- β -d-glucosaminidase, β -d-glucuronidase, β -d-galactosidase) [27]. In addition, curcumin can decrease the levels of thiobarbituric acid reactive substances (TBARS) and the activity of sorbitol dehydrogenase (SDH) [15, 24, 35].…”

Recent Progress for the Utilization of Curcuma longa, Piper nigrum and Phoenix dactylifera Seeds against Type 2 Diabetes

“…El-Moselhy et al, in their study, described that an oral dose of 80 mg of curcumin, given for 60 and 15 days to rats with induced Type 2 diabetes and high fat diet insulin resistance, had antidiabetic activity (26), while another study conducted in 2012 reported that dietary curcumin was effective in controlling the increased levels of fasting blood glucose (27).…”