Effect of curcumin (Curcuma longa extract) on LPS-induced acute lung injury is mediated by the activation of AMPK

Kim, Joungmin; Jeong, Seongwook; Quan, Hui; Chang-hyun, Jeong; Choi, Jeong-Il; Bae, Hong-Beom

doi:10.1007/s00540-015-2073-1

Cited by 33 publications

(28 citation statements)

References 39 publications

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“…It also prevents the production of IL‐8, macrophage inflammatory protein (MIP)‐1α, (MCP‐1), and TNF‐α) by downregulating NF‐κB signaling pathway) by monocytes and macrophages (ABE, Hashimoto, & HORIE, ). Furthermore, curcumin significantly suppressed IL‐12 generation by decreasing the expression of NF‐κB in LPS‐stimulated macrophages (Kim et al, ) that inhibited Th‐1 cytokine profile (increased IL‐4 production and decreased IFN‐γ) in CD4+ T cells (Yadav, Mishra, Singh, Mehrotra, & Singh, ).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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Sepsis is a complex disease that begins with an infectious disorder and causes excessive immune responses. Curcumin is considered as an active component of turmeric that can improve the condition in sepsis due to its anti‐inflammatory and antioxidant properties. PubMed, Embase, Google Scholar, Web of Science, and Scopus databases were searched. Searching was not limited to a specific publication period. Only English‐language original articles, which had examined the effect of curcumin on sepsis, were included. At first, 1,098 articles were totally found, and 209 articles were selected after excluding duplicated data; 46 articles were remained due to the curcumin effects on sepsis. These included 23 in vitro studies and 23 animal studies. Our results showed that curcumin and various analogs of curcumin can have an inhibitory effect on sepsis‐induced complications. Curcumin has the ability to inhibit the inflammatory, oxidative coagulation factors, and regulation of immune responses in sepsis. Despite the promising evidence of the therapeutic effects of curcumin on the sepsis complication, further studies seem necessary to investigate its effect and possible mechanisms of action in human studies.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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“…Furthermore, they may be secreted by inflammatory cells activated during lung injury processes, including macrophages and lymphocytes, which may have biological effects in the lung (26). In cytokines participating in radiation-induced lung injury, TGF-β has a predominant role and is a major cytokine, which has been most thoroughly researched.…”

Section: Discussionmentioning

confidence: 99%

Salvianolic acid B attenuates lipopolysaccharide-induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation

Zhao

Liu

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The present study was performed to assess the protective effect of salvianolic acid B on lipopolysaccharide (LPS)-induced acute lung injury (ALI). Sprague Dawley rats were injected with 100 µg/kg LPS through a 24-gauge catheter. One group of rats was pre-treated with salvianolic acid B (1 mg/ml; 20 ml/kg body weight) 1 h prior to LPS challenge, then 20 ml/kg salvianolic acid B every 2 days for 4 weeks thereafter. Salvianolic acid B attenuated LPS-induced increases in the lung wet/dry weight rate and lung tissue injury in ALI model rats. LPS-induced changes in the content of caspase-3, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, tumor necrosis factor-α and interleukin-6 in ALI model rats were attenuated by treatment with salvianolic acid B. Furthermore, treatment with salvianolic acid B inhibited the protein expression of type I collagen I, endogenous transforming growth factor-β1 production and α-smooth muscle actin in ALI model rats. These findings indicated that salvianolic acid B attenuates LPS-induced ALI through inhibition of apoptosis, oxidative stress and inflammation in rats and therefore exertsa protective effect against ALI.

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“…TNF‐α, MIP‐2, IL‐6, and MPO levels and the wet/dry weight ratio of lung and neutrophil accumulation in BALF were reduced by curcumin in LPS‐induced acute lung injury in mice . It has also been reported that curcumin is able to scavenge free radicals (peroxides), phenolic oxidants, and nitric acid and to inhibit lipid peroxidation induced by chemical agents .…”

Section: Introductionmentioning

confidence: 99%

Anti‐inflammatory, antioxidant, and immunomodulatory effects of curcumin in ovalbumin‐sensitized rat

Shakeri

Boskabady

2017

BioFactors

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Effect of curcumin (Curcuma longa extract) on LPS-induced acute lung injury is mediated by the activation of AMPK

Cited by 33 publications

References 39 publications

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Salvianolic acid B attenuates lipopolysaccharide-induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation

Anti‐inflammatory, antioxidant, and immunomodulatory effects of curcumin in ovalbumin‐sensitized rat

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