Effect of curcumin nanoparticles on the cisplatin-induced neurotoxicity in rat

Khadrawy, Yasser A.; El-Gizawy, Mayada M; Sorour, Safwa M.; Sawie, Hussein G; Hosny, Eman N

doi:10.1080/01480545.2018.1504058

Cited by 28 publications

(23 citation statements)

References 62 publications

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“…It has been found that CP injection elicits many histopathological alterations in brain tissue [4,27,28]. Similarly, in our study, the cerebral and cerebellar tissue of the CP-injected group presented with vacuolations, a marked shrinkage in pyramidal neurons, perineural edema with extensively dark pyknotic nuclei, deeply stained Purkinje cells with pyknotic nuclei, and loss of Purkinje nerve fibers.…”

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

“…Furthermore, CP-induced oxidative stress in brain tissue triggers oxidative damage and apoptotic cell death [25,27]; therefore, apoptosis could be considered the third mechanism implicated in CP-induced neurotoxicity. The initial crucial step in apoptosis is caspase activation [26,27]. A marked upregulation of caspase-3 protein expression in brain tissue in the CP-injected rats in comparison to the control rats was recorded in our study.…”

Section: Discussionmentioning

confidence: 99%

“…A marked upregulation of caspase-3 protein expression in brain tissue in the CP-injected rats in comparison to the control rats was recorded in our study. It was documented that the increased protein level and expression of the executive caspases such as caspase-3 in brain tissue following CP administration mediated the neuronal apoptotic programmed cell death [25,27].…”

Section: Discussionmentioning

confidence: 99%

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Neuroprotective Potential of Bone Marrow-Derived Mesenchymal Stem Cells Following Chemotherapy

2021

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Cisplatin (CP) is extensively used in the medical oncology field for malignancy treatment, but its use is associated with neurological side effects that compromise the patients’ quality of life. Cytotherapy is a new treatment strategy for tissue damage that has recently emerged. The use of bone marrow-derived mesenchymal stem cells (BM-MSCs) was investigated for its therapeutic potential against CP-induced chemobrain as well as various models of brain damage. This study was carried out to elucidate, for the first time, the role of the intravenous injection (IV) of BM-MSCs against CP-induced neurotoxicity in a rat model through investigation of the parameters of oxidative stress, inflammation, and apoptosis in brain tissue. A rat model of neurotoxicity was generated by intraperitoneal injection of 7.5 mg/kg CP while 2 × 106 BM-MSCs was given by IV as a therapeutic dose. Injection of CP led to a significant rise in malondialdehyde and nitric oxide levels accompanied by a marked depletion of superoxide dismutase and reduced glutathione content in brain tissue in comparison to the normal control (NC) rats. Furthermore, a remarkable rise in the brain levels of inflammatory cytokines interleukin (IL)-1β and IL-6, together with the expression of apoptotic marker caspase-3, and the downregulation of the brain expression of proliferating marker Ki-67 in brain tissue were detected in the CP group compared to the NC group. Histopathological alterations were observed in the brain tissue of the CP group. BM-MSCs mitigated the biochemical and histopathological alterations induced by CP without affecting brain cell proliferation. BM-MSCs could be used as a promising neuroprotective agent against CP-induced neurotoxicity.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Neuroprotective Potential of Bone Marrow-Derived Mesenchymal Stem Cells Following Chemotherapy

2021

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“…Our results showed that Cis causes severe cerebral damage which is manifested by a significant increase of CHE and GGT activities in the Cis group in comparison with the control group. These findings are in agreement with [50][51][52]. References [53,54] reported that GGT is posited as an early and a delicate marker for brain damage.…”

Section: Discussionsupporting

confidence: 89%

Ginkgo biloba Alleviates Cisplatin-Mediated Neurotoxicity in Rats via Modulating APP/Aβ/P2X7R/P2Y12R and XIAP/BDNF-Dependent Caspase-3 Apoptotic Pathway

et al. 2020

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Neurotoxicity is an obvious adverse effect in Patients encountering a complete course of chemotherapy. The present work is conducted to evaluate the neuroprotective effect of Ginkgo biloba (Ginkgo) against the neurotoxicity induced by Cisplatin (Cis) in rats. Forty male Wistar albino rats were arranged into four groups: (1) Control group, rats were given saline; (2) Cis group, rats were injected by Cis 2 mg/kg body weight i.p., twice a week starting on the fifth day for thirty days; (3) Ginkgo group, rats were administered Ginkgo (50 mg/kg orally) daily for thirty days; and (4) Ginkgo+Cis group, rats received Ginkgo (50 mg/kg orally) daily and on the fifth day, rats were injected with Cis (2 mg/Kg body weight i.p.) twice a week for thirty days. Cis significantly increased Gamma glutamyltransferase (GGT) and Acetyl Cholinesterase (CHE) as compared to the control group and also disturbed cerebral oxidative/antioxidant redox. Co-administration of Ginkgo and Cis reversed the adverse effect of Cis on the brain tissue. Moreover, co-administration of Ginkgo and Cis ameliorated Cis induced brain damage by reducing Amyloid precursor protein (APP), amyloid β (Aβ), P2Y12R and P2X7R mRNA expressions and proteins. Furthermore, Ginkgo regulated XIAP/BDNF expressions with a consequent decrease of caspase-3 and DNA fragmentation%. The current results concluded that concurrent treatment with Ginkgo can mitigate neurotoxicity mediated by Cis in experimental animals through exhibiting antioxidant effect by restoring cerebral oxidative/antioxidant redox and anti-apoptotic effect via regulating cerebral APP/Aβ/P2Y12R/P2X7R and XIAP/BDNF signaling pathways.

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Antinociceptive, Anti‐Hyperalgesia and Antiallodynic Activities of Polyphenol Rich Extract fromShorea roxburghiiagainst Cyclophosphamide Induced Peripheral Neuropathy

Wang

Olatunji

Xue

2021

Chemistry & Biodiversity

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Cyclophosphamide (CYP) is a widely used antineoplastic and immunosuppressive drug, however, despite its efficacy, it has shown extensive multiple organ toxicities, including peripheral neuropathy which significantly affects the quality of life of cancer patients. This study elucidated the protective properties of Shorea roxburghii polyphenol extract (SLPE) in CYP‐induced peripheral neuropathy. Rats were treated with SLPE (100 and 400 mg/kg) for five weeks plus CYP once a week from the second week of SLPE treatment. Using UHPLC‐QTOF‐MS, 54 polyphenolic compounds were identified in SLPE extract. After the treatment period the antinociceptive, anti‐hyperalgesia and antiallodynic effects was evaluated using formalin paw edema, acetic acid abdominal writhing, hot plate, tail immersion and von Frey filament tests. While the locomotive and motor coordination effects were evaluated by open field and rotarod tests. The administration of CYP led to significant increases in mechanical and thermal hyperalgesia, in addition to hyper‐nociceptive responses in the formalin and acetic acid writhing tests. CYP also significantly reduced locomotive activity and motor coordination. SLPE significantly protected against CYP‐induced mechanical and thermal hyperalgesia. Furthermore, SLPE displayed robust antinociceptive effect by counteracting formalin and acetic acid induced hyper‐nociception. In addition, SLPE increased the locomotive activity as well as the grip and motor coordination of the CYP treated rats. In conclusion, these results revealed the protective effects of SLPE against CYP‐induced peripheral neuropathy and could be an effective therapeutic remedy for chemotherapy induced peripheral neuropathy.

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Effect of curcumin nanoparticles on the cisplatin-induced neurotoxicity in rat

Cited by 28 publications

References 62 publications

Neuroprotective Potential of Bone Marrow-Derived Mesenchymal Stem Cells Following Chemotherapy

Neuroprotective Potential of Bone Marrow-Derived Mesenchymal Stem Cells Following Chemotherapy

Ginkgo biloba Alleviates Cisplatin-Mediated Neurotoxicity in Rats via Modulating APP/Aβ/P2X7R/P2Y12R and XIAP/BDNF-Dependent Caspase-3 Apoptotic Pathway

Antinociceptive, Anti‐Hyperalgesia and Antiallodynic Activities of Polyphenol Rich Extract fromShorea roxburghiiagainst Cyclophosphamide Induced Peripheral Neuropathy

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