Effect of curcumin on chromium-induced oxidative damage in male reproductive system

Chandra, Amar K.; Chatterjee, A. K.; Ghosh, Rituparna; Sarkar, Mitali

doi:10.1016/j.etap.2007.04.009

Cited by 56 publications

(40 citation statements)

References 40 publications

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“…Administration of Cr (VI) induced pathological results on reproductive system of male rats and this could be attributed to chromium induced oxidative damage (Stohs et al, 2001). Our pathological results were comparable to those reported by Chandra et al, (2007) and Rankov et al, (2010). Moreover, the recorded significant reduction in serum testosterone level of Cr (VI) intoxicated rats after ten weeks has been reported by Marouani, (2011);Jeber and Tawfeek, (2013);Al-Mukhtar et al (2016).…”

Section: Discussionsupporting

confidence: 81%

“…This variation could be contributed to the intracellular reduction of Cr (VI) producing pentavalent (Cr V) form of chromium that may disrupt the blood-testis barrier and affect the functions of Sertoli cells (Pereira et al, 2002). Low level of serum testosterone in Cr (VI) treated rats may correlate to the spermatogenic impairment and depleted epididymal sperm number (Chandra et al, 2007) as, testosterone is essential for the motivation and conservation of spermatogenesis (Singh et al, 1995). In the same way, the Cr (VI) treated rats showed significant drop in sperm count with numerical increase in sperm abnormalities after ten weeks (Yousef et al, 2006;Akunna et al, 2012).…”

Section: Discussionmentioning

confidence: 93%

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Pathological Evaluation of The Effect of Zinc Oxide Nanoparticles on Chromium-Induced Reproductive Toxicity in Male Albino Rats

Ibrahim¹,

Oda²,

Khafaga³

2017

AJVS

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Key words: Zinc oxide, Nanoparticles, Pathology, Testes, Rat.The present study was intended to evaluate the effect of zinc oxide nanoparticles (ZnO-NPs) on chromium (Cr VI)-induced reproductive toxicity in male rats. Forty adult male albino rats were randomly divided into four equal groups (10 rats each), control group, chromium (Cr VI) group, potassium dichromate (K2Cr2O7) given orally at dose 10.5 mg/kg bwt/day (equals to 1/10 of LD50) (five days a week), Cr VI + ZnO-NPs group, rats received 10.5 mg/kg bwt/day (five days a week K2Cr2O7 orally and injected intraperitoneally (IP) by ZnO-NPs-saline solution at dose 5 mg/kg bwt/ day (three days a week). ZnO-NPs-group, ZnO-NPs-saline solution (IP) at dose 5 mg/kg bwt/ day (three days a week). Ten weeks post-treatment, serum testosterone values were significantly decreased in the Cr (VI) and Cr (VI) + ZnO-NPs-treated rats, sperm counts and significant increase in sperm abnormalities. No significant alteration in testicular malondialdehyde and superoxide dismutase levels among treated groups all over the experiment compared to control. However, reduced glutathione concentrations in testes were significantly decreased in Cr (VI) + ZnO-NPs and ZnO-NPs groups at ten weeks post-treatment. Cr (VI) group showed marked histopathological alterations and to lesser extent Cr (VI) + ZnO-NPs group that were time dependent. ZnO-NPs group showed significant testicular lesions, particularly after ten weeks post-treatment. It could be concluded that Cr (VI) intoxication induced damaging effects on male reproductive functions that were time dependent. ZnO-NPs partially improved these effects. But, its use for longer period has no valuable effect on Cr (VI)-induced toxicity.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 93%

Pathological Evaluation of The Effect of Zinc Oxide Nanoparticles on Chromium-Induced Reproductive Toxicity in Male Albino Rats

Ibrahim¹,

Oda²,

Khafaga³

2017

AJVS

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“…Chrome on seminal vesicle (14). According to the studies, no report has been provided about the effect of curcumin on rat's seminal vesicle treated with sodium arsenite yet.…”

Section: Introductionmentioning

confidence: 99%

“…Antioxidant properties of curcumin and male reproductive system protection against oxidative stress and environmental pollutants such as nitrates, aflatoxins, cadmium, chromium, acrylamide and lindane have been noted in many studies (14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

“…Curcumin or C12H20O6 is a polyphenol and the most active component of curcuma longa (12) which acts as a free radical cleansing and is considered as an effective antioxidant against oxidative stress damage which can significantly inhibit the production of reactive oxygen species both in Vivo and in Vito (13,14). Antioxidant properties of curcumin and male reproductive system protection against oxidative stress and environmental pollutants such as nitrates, aflatoxins, cadmium, chromium, acrylamide and lindane have been noted in many studies (14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

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Stereological Study of the Protective Role of Curcumin on Histological Changes of Seminal Vesicle in Mice Following Treatment with Sodium Arsenite

Mahmoodi

Mehranjani

2017

J Urmia Univ Med Sci

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Curcumin nanomicelle improves semen parameters, oxidative stress, inflammatory biomarkers, and reproductive hormones in infertile men: A randomized clinical trial

Alizadeh

Javadi

Karami

et al. 2017

Phytotherapy Research

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At least 50% of infertile couple's problems are related to male factor infertility. This Randomized, Double-Blind, Placebo-Controlled Clinical Trial conducted in Urology unit of Infertility Clinic on 60 infertile men. Patients were randomly assigned to one of intervention and placebo (n = 30) groups. Finally, 28 subjects in each group completed the study. Participants in the intervention group took daily 80 mg curcumin nanomicelle and those in the placebo group took daily placebo for 10 weeks. Semen analysis, anthropometric, physical activity assessments, total antioxidant capacity, malondialdehyde, inflammatory factors, and reproductive hormones were measured at the baseline and at the end of the study. At the end of study, statistically significant differences were seen in the total sperm count, sperm concentration, and motility in the intervention group to the control group. In treatment group, the total sperm count, sperm concentration, and motility levels were also statistically increased at the end of study compared to the baseline values. Curcumin nanomicelle supplementation also resulted in a statistically significant improvement in plasma levels of total antioxidant capacity, malondialdehyde, C-reactive protein, and tumor necrosis factor a in comparison to the placebo. Medical therapy of asthenoteratospermia with curcumin nanomicelle supplement could improve quality of semen parameters. However, further investigation is suggested in this regard.

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Effect of curcumin on chromium-induced oxidative damage in male reproductive system

Cited by 56 publications

References 40 publications

Pathological Evaluation of The Effect of Zinc Oxide Nanoparticles on Chromium-Induced Reproductive Toxicity in Male Albino Rats

Pathological Evaluation of The Effect of Zinc Oxide Nanoparticles on Chromium-Induced Reproductive Toxicity in Male Albino Rats

Stereological Study of the Protective Role of Curcumin on Histological Changes of Seminal Vesicle in Mice Following Treatment with Sodium Arsenite

Curcumin nanomicelle improves semen parameters, oxidative stress, inflammatory biomarkers, and reproductive hormones in infertile men: A randomized clinical trial

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