Effect of curcumin on dexamethasone-induced testicular toxicity in mice

Khorsandi, Layasadat; Mirhoseini, Mehri; Mohamadpour, Masoomeh; Orazizadeh, Mahmoud; Khaghani, Soheila

doi:10.3109/13880209.2012.716854

Cited by 55 publications

(48 citation statements)

References 38 publications

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“…Six microscopic H&E stained slides per animal were examined for assessment of histological changes such as cellular swelling and diameters of islets which assessed by using Motic Images Plus 2.0 image analysis software. Finally, a blind method was used for slides reading(1516). …”

Section: Methodsmentioning

confidence: 99%

Pancreatic protective and hypoglycemic effects of Vitex agnus-castus L. fruit hydroalcoholic extract in D-galactose-induced aging mouse model

et al. 2017

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D-galactose induces pancreatic disorder along with aging mouse model. Vitex agnus-castus (VAC) has potential pancreatic protective effect. Hence, this study was designed to evaluate the hypoglycemic and pancreas protective effects of VAC hydroalcoholic extract in D-galactose-induced aging female mice. In the present experimental study, 72 adult female Naval Medical Research Institute (NMRI) mice (weighing 30–35 g) were divided into 6 groups of control, VAC hydroalcoholic extract, D-galactose, D-galactose + VAC hydroalcoholic extract, aged, aged + VAC hydroalcoholic extract. The aged model was prepared by subcutaneous injection of D-galactose for 45 days and, VAC hydroalcoholic extract was gavaged twice a day in the last 7 days. 24 h after the last drug and extract administrations, serum samples and pancreatic tissues were removed to evaluate experimental and histological determinations. Serum glucose level decreased in VAC, D-galactose and, aged-treated groups compared to the control (P < 0.05). Insulin level increased in VAC and decreased in D-galactose and aged VAC-treated mice compared to the control (P < 0.05). Homeostasis model assessment-estimated insulin resistance (HOMA-IR) increased in D-galactose, aging, and VAC hydroalcoholic extract groups (P < 0.05) and, administration of VAC hydroalcoholic extract improved HOMA-IR in D-galactose and aging treated animals. Despite the size of pancreatic islets decreased in aged and D-galactose groups, VAC administration recovered it. Present data showed that VAC hydroalcoholic extract has hypoglycemic and pancreatic protective effects in natural aged and aging model mice.

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Section: Methodsmentioning

confidence: 99%

Pancreatic protective and hypoglycemic effects of Vitex agnus-castus L. fruit hydroalcoholic extract in D-galactose-induced aging mouse model

et al. 2017

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“…Additionally, Curc umin is useful as a valuable protec tive agent t o ameli orat e spermat ogenesis d ysf uncti on and cell loss (Khorsandi et al, 2013). It m ay als o be us ef ul in at tenuati ng multiple organ injur y i n pathological c onditions arising due t o exc essive infiltration of neutr ophils int o the tissues (Medan and Ghos h, 2003).…”

Section: Discussionmentioning

confidence: 99%

The Potential Ameliorative Effect of Curcumin in Schistosoma Mansoni Infected Mice: An Ultrstructural Study on the Testes

Mira¹

2017

Egypt. J. Exp. Biol. (Zoo.)

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N ab i l a Mous a Mi r aT he potential ameli orativ e effect of curcu min i n Sc histoso ma mansoni infecte d mic e: an ultrastru ctural study on the testes ABSTRACT:This inves tigation has been designed t o eval uate the antibilharzial ef ficienc y and th e possible amelior ativ e r ole of c urc umin on adult m ale Swiss albino mic e tes tes . T hirt y anim als were us ed in t his experiment , divided equall y into 3 groups: group 1, c ontr ol group; group 2, inf ect ed with S. mans oni, and group 3, infec ted mice treat ed with c urcumin.Ultrastruc tur e examinati on was perform ed on the tes tes usi ng transmissi on electron microscop y (TE M). R es ults i ndicat ed that the test es in t he inf ec ted group s howed thick eni ng and irregul arit y i n t he s urrounding basal l amina, c yt oplasmic vac uolat i on of atrophi ed Sert oli c ells, shrinkage and p yk notic nucl ei of spermat ogonia , as w ell as primar y spermat oc yt es, especiall y i n fr ont of t he s ex vesicles . Furt hermore, S ertoli c ells c ont ai ned various f orms of mitoc hondrial d egeneration and wide int ercell ul ar sp aces of adherent juncti on am ong the S ertoli, as w ell as spermat ogenic c ells. B esides, m ost of sperms were mark edly aff ect ed. Supplement ati on of curcumi n minimized the degener ativ e chang es in t he nucl ear envel ope and sex v esicles of the primar y spermat oc yte nucl ei besides narrowi ng the adherent juncti on among S ertoli cells and germ c ells. In c onclusi on, c urcumi n proved to hav e a pot ential rol e i n minimizing the deleteri ous ef fec t of S. m ansoni in t est es of t he infec ted mic e. KEY WORDS:Schis tos oma mans oni, Swiss albino mice, test es, curc umin, ultr astr uct ure

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“…Other studies have reported that curcumin provides support to the antioxidant enzyme systems, which reduce oxidative stress and lipid production in order to protect steroidogenesis and spermatogenesis against toxic agents (37)(38)(39)(40)(41)(42)(43)(44)(45)(46). In our light microscopic examinations of the nicotine + curcumin groups, we observed generally normal seminiferous tubules and interstitium ( Figures 2F, 2G, 2H, and 2I).…”

Section: Discussionmentioning

confidence: 99%

“…Studies on the effects of curcumin on male infertility have increased in recent years (38)(39)(40)(41)(42)(43)(44)(45)(46). The antioxidant activity of curcumin in opposition to nicotine toxicity was investigated in the lung, liver, and kidney.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that curcumin, as a potential antioxidant of ROS, neutralizes nitric oxide, provides continuity to antioxidant enzymes such as superoxide dismutase and catalase, and lowers lipid peroxidation in order to protect tissues and organs from oxidative damage caused by nicotine (36,37). Furthermore, curcumin appeared to be effective in enhancing male hormones, sperm count, motility, and morphology, and in reducing reproductive toxicity (38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55). The results suggested that curcumin could be useful in inhibiting the harmful effects of nicotine on the testes.…”

Section: Introductionmentioning

confidence: 99%

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Ameliorating effects of curcumin on nicotine-induced mice testes

et al. 2016

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IntroductionTobacco addiction is the leading preventable cause of death, but the number of smokers is still rapidly increasing, particularly in undeveloped and developing countries (1,2).Cigarette smoking kills people by causing a wide range of diseases such as vascular disease and chronic lung disease. Principally, it increases the risk of mouth, oral cavity, pharynx, larynx, esophagus, pancreas, lung, cervix, bladder, and kidney cancers (2-5). Moreover, maternal smoking is the greatest identified cause of fetal weight deficiency, premature birth, miscarriage, perinatal/ neonatal death, neural tube defects, and congenital anomalies (6-11). Furthermore, it adversely affects the development of organs and tissues serving several functions in cardiovascular and skeletal systems (12).Nicotine is a major toxic component of cigarette smoke. Moreover, it is a strong alkaloid, which is isolated from tobacco leaves (13,14). It has been reported that nicotine passes through biological membranes, including the blood-brain barrier, and induces apoptosis and malformations (15). In addition to its pathogenic toxic effects on tissues and organs, nicotine has an impact on gonadal functions and inhibits ovulation, estradiol production, and fertilization (16)(17)(18). The production of free radicals (ROS), which impair the antioxidant system, is increased by nicotine (19,20). Therefore, an imbalance between ROS production and ROS elimination by the antioxidant system can cause oxidative stress in tissues (19)(20)(21)(22). As a cause of oxidative stress, it is well known that nicotine has detrimental effects on sperm count, motility, and morphology, and it impairs testicular structure and function, reducing the level of serum testosterone and estradiol (23-28). Antioxidant capacity against oxidative damage is extremely important for organs such as the testes, which have high metabolic activity and cell replication (29,30).Turmeric (Curcuma longa) is a perennial plant that has been used as a spice and medicine in Asian and African countries for thousands of years (31,32). Curcumin, which is obtained from turmeric roots, is used as an antiinflammatory, antiseptic, antioxidant, anticarcinogenic, and hypocholesterolemic agent in traditional medicine (33)(34)(35)(36). It is known that curcumin, Background/aim: The aim of this study was to determine the antioxidative effect of curcumin on nicotine-induced mice testis.Materials and methods: Sixty Swiss albino male mice were divided into five groups, each containing 12 mice. The first group was used as a control. To induce toxicity in the second and third group, nicotine (0.4 mg/kg/day) was injected intraperitoneally into mice for 14 and 28 days, respectively. The mice in the fourth and fifth group were injected with nicotine (0.4 mg/kg/day) and orally treated with curcumin (200 mg/kg) for 14 and 28 days, respectively. Testosterone levels were measured from blood samples and testis tissues were examined under light and electron microscopes.Results: Light and electron microscopic examinatio...

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Effect of curcumin on dexamethasone-induced testicular toxicity in mice

Cited by 55 publications

References 38 publications

Pancreatic protective and hypoglycemic effects of Vitex agnus-castus L. fruit hydroalcoholic extract in D-galactose-induced aging mouse model

Pancreatic protective and hypoglycemic effects of Vitex agnus-castus L. fruit hydroalcoholic extract in D-galactose-induced aging mouse model

The Potential Ameliorative Effect of Curcumin in Schistosoma Mansoni Infected Mice: An Ultrstructural Study on the Testes

Ameliorating effects of curcumin on nicotine-induced mice testes

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