Effect of curcumin on tendon healing: an experimental study in a rat model of Achilles tendon injury

Güleç, Ali; Turk, Yilmaz; Aydın, Bahattin Kerem; Erkoçak, Ömer Faruk; Safali, Selim; Uğurluoğlu, Ceyhan

doi:10.1007/s00264-018-4017-5

Cited by 18 publications

(22 citation statements)

References 25 publications

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“…[12,13] In our study, the well-known Achilles tendon model was used. [14] In our model, the systemic effect was obtained by the administration of TXA through intraperitoneal route, and the local effect through the injection of TXA in the tendon repair site after suturing the skin. In this way, both forms of application of TXA in total knee arthroplasty were simulated.…”

Section: Discussionmentioning

confidence: 99%

Histopathological and immunohistochemical investigation of the local and systemic effects of tranexamic acid on the healing of the Achilles tendon in rats

et al. 2021

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Objectives This study aims to compare the effects of systemic and local applications of tranexamic acid (TXA) on tendon healing using a rat Achilles tendon injury model. Patients and methods Thirty-six adult male albino Wistar rats (aging 3-4 months; weighing 350 to 400 g) were used in this study conducted between December 2019 and January 2020. The Achilles tendon was performed bilateral tenotomy and surgically repaired. Postoperatively, 1 mL of TXA was administered to each leg locally in the local group, whereas 2 mL of TXA was intraperitoneally administered in the systemic group. The control group was left untreated. Half of the rats were sacrificed on Day 15 and the other half on Day 30. Tendon healing was evaluated with the Bonar and the Movin scoring systems and immunohistochemical methods. Results The systemic group had the highest Bonar and Movin scores on Day 15. All groups exhibited tendon healing on Day 30, with no significant differences among the groups. The tenocyte morphology was found to be more impaired in both TXA groups on Day 30 (p=0.013). Ground substance scores were lower in the systemic group on Day 30 (p=0.028). The fiber structure and arrangement scores were higher in the systemic group on Day 15 (p=0.007 and p=0.032). Immunohistochemical analyses showed that galectin-3 values exhibited a significant difference in all groups on Day 30 (p=0.020). In all groups, it was determined that type I collagen values showed an increasing trend on Day 30, compared to the values on Day 15, whereas type III collagen values showed a decreasing trend. Conclusion Our results demonstrated that local and systemic use of TXA does not impair tendon healing. Although advanced studies are needed, our study suggests that TXA application reduces the development of fibrosis.

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Section: Discussionmentioning

confidence: 99%

Histopathological and immunohistochemical investigation of the local and systemic effects of tranexamic acid on the healing of the Achilles tendon in rats

et al. 2021

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“…The standard staining protocol was based on hematoxylin and eosin, while the most popular additional staining method was Alcian Blue [1,[34][35][36][37][38][39][40][41][43][44][45][46][47]49] The second most frequent method was Masson Trichrome [16,34,36,[38][39][40][42][43][44]47,50]. Other staining methods, such as Picrosirius red Verhoeff van Gieso, Gridley method, Gomori method, Safranin, Toluidine Blue, and Alizarin Red, were rather rare [37,44].…”

Section: Methodology Of Microscopic Investigationmentioning

confidence: 99%

“…Most of the collected studies included an assessment of the tendons' histopathology based on the classical Bonar score with four variables [1,16,34,36,[38][39][40][41][42][43][44][46][47][48][49][50][51][52][53]. However, a few authors aimed to modify the classical assumptions of the scoring system in order to improve the diagnostics and microscopic evaluation.…”

Section: The Bonar Score and Its Modificationsmentioning

confidence: 99%

“…An evaluation of therapeutic effects showed 15 positive results [1,[38][39][40][42][43][44]46-53], 6 negative results [34][35][36][37]41,45], and 1 neutral result of treatments [16] (Table 3). The studies with positive therapeutic effects represented the following methods: curcumin application, autologous conditioned serum application, low-molecular-weight heparin and rivaroxaban injection, vitamin C and hyaluronic acid injection, TGF-β1 used with the scaffold, subacromial bursa excision, erythropoietin application, interleukin-1 receptor antagonist application, adipose-derived stem cell injection, bevacizumab application, and, in five studies, PRP application.…”

Section: Therapeutic Effectsmentioning

confidence: 99%

“…Acute injuries of the tendons are among the most common in the human body [1]. The injured tendon healing process consists of three main phases, which are essential for soft tissue healing.…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Advances in Tendinopathy Quantified Microscopically Using Bonar Score, with a Special Reference to PRP Therapy—A Systematic Review of Experimental Studies

et al. 2021

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(1) Background: The Bonar scoring system serves in the microscopic evaluation of tendon pathology. However, it can be easily adapted to investigate decreasing degeneration after treatment and quantify the healing progress. We believe that there is an actual need for a connection between clinical observations and tissue alterations arising during the treatment process, to gain superior functional outcomes. Herein, we perform a systematic review of the Bonar score’s application in the histopathological assessment of therapeutic advances in tendinopathy, with special reference to PRP therapy. (2) Methods: A systematic review was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The searching strategy was conducted across major databases: PubMed, Cochrane Central, ScienceDirect, SciELO, and Web of Science. The risk-of-bias assessment was made using the Cochrane Collaboration’s Risk of Bias Tool and SYRCLE. (3) Results: The searching strategy produced 807 articles, and after selection, 22 studies were included. We collected 21 animal studies (n = 472) and 1 human study (n = 45). Three types of tendons were taken into account: 14 Achilles tendons, 7 supraspinatus tendons (SST), and in 1 case, Achilles and patellar tendons simultaneously. A variety of therapeutic methods were used—from intra-tendinous substance injections to surgical procedures or mechanical stimuli—but platelet-rich plasma (PRP) therapy dominated among them and was present in six studies. Most of the collected studies included an assessment of the tendons’ histopathology based on the classical Bonar score (with four variables and one observer). The staining protocol was based on the hematoxylin and eosin technique. An evaluation of therapeutic effects showed 15 positive results, 6 negative results, and 1 neutral result of treatments. (4) Conclusions: To understand the tendinopathy phenomenon, a link between histopathology and clinical observations in chronic tendon disorders is required due to the possibility of functional outcome improvements. The Bonar scoring system is well established in tendon pathology assessment and could also be adopted to assess therapeutic results in tendon disorders. Studies that included the PRP application showed Bonar-scoring-system-based evidence of superior tendinous tissue healing related to improved clinical results.

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The effect of Sildenafil, a phosphodiesterase-5 inhibitor, on tendon healing: an experimental study in rat model of achilles tendon injury

Kurt,

Guner,

Kayacan

et al. 2023

Arch Orthop Trauma Surg

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Effect of curcumin on tendon healing: an experimental study in a rat model of Achilles tendon injury

Abstract: Curcumin had better results for total tendon healing not only histologically but also biomechanically. Curcumin could be an additional agent in the management of surgically repaired tendon injuries.

Cited by 18 publications

References 25 publications

Histopathological and immunohistochemical investigation of the local and systemic effects of tranexamic acid on the healing of the Achilles tendon in rats

Histopathological and immunohistochemical investigation of the local and systemic effects of tranexamic acid on the healing of the Achilles tendon in rats

Therapeutic Advances in Tendinopathy Quantified Microscopically Using Bonar Score, with a Special Reference to PRP Therapy—A Systematic Review of Experimental Studies

The effect of Sildenafil, a phosphodiesterase-5 inhibitor, on tendon healing: an experimental study in rat model of achilles tendon injury

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