Effect of curcumine on the formation of epidural fibrosis in an experimental laminectomy model in rats

Abstract

fat graft, collagen membrane, Adcon-L, and fibrinolytic agents but no effective treatment option was found (6,8,9,17,19,22). Curcumin (diferuloylmethane) gives turmeric its yellow color (the ground rhizome of Curcuma longa L.), and is often employed as a spice and is recognized for its anti-inflammatory features (1,16). Curcumin affects the nuclear factor kappa β (NF-κB) in pro-inflammatory cytokine reproduction, the antiapoptotic process, the functioning of leukocytes, and cell survival (1). AIM:To clarify the effects of topical application of curcumin on the prevention of epidural fibrosis. MATERIAL and METHODS:Twenty-one rats were randomly divided into three equal groups (control, spongostan, local curcumin) and a laminectomy procedure was performed between T11 and L1 in all rats. Subsequently, spongostan soaked with curcumin (100 mg/kg) was applied topically. After four weeks, the vertebral column from T9 to L3, which included the paraspinal muscles and epidural scar tissue, was removed as a single piece and the epidural fibrosis and arachnoidal scarring were graded and histopathological analysis carried out accordingly. Kruskal-Wallis and Pearson Chi-Square tests were used for statistical analysis. A p-value of less than 0.05 was considered to be significant. RESULTS:The grading of epidural fibrosis was far lower in the experimental group with curcumin compared to the control and spongostan groups, but the difference was not statistically significant. CONCLUSION:The findings of this study show that local curcumin decreases the formation of epidural fibrosis and this effect of curcumin is thought to be mediated by reducing the functions of inflammatory cells such as macrophages, neutrophils and fibroblasts, and the anti-inflammatory and antioxidant effects.

Impact of radial extracorporeal shock wave therapy in post-laminectomy epidural fibrosis in a rat model

“…For the inhibition of specific inflammatory cytokines, etanercept, a TNF-α blocker, [1] tamoxifen, a TGF-β blocker, [7] methyl palmitate, [18] and dexmedetomidine [4] have been extensively investigated. Also, there are studies using diclofenac sodium [20] and curcumin [21] as anti-inflammatory agents. All these studies showed that both inflammatory cytokine inhibition and the use of anti-inflammatory agents significantly reduced the development of epidural fibrosis by producing anti-inflammatory and antioxidant effects.…”

The role of hemostatic devices in neurosurgery. A systematic review

“…Moreover, an appropriately placed subdural gelatin sponge over cerebral tissue may prevent postoperative surgical adhesions after neurosurgical procedures [18]. However, it has been reported that gelatin sponges may be related to increased odds of epidural fibrosis [21][22][23], and care must be taken when they are used in confined space because of their absorption capability and the related swelling of the sponge.…”

Antifibrotic Effect of Bletilla striata Polysaccharide-Resveratrol-Impregnated Dual-Layer Carboxymethyl Cellulose-Based Sponge for The Prevention of Epidural Fibrosis after Laminectomy

“…Laminectomy is a surgical procedure typically employed in the treatment of numerous spinal disorders such as lumbar disk herniation, spinal stenosis, and tumor excision [ 1 ]. Although this treatment is generally effective and relieves neural compression, 8–40% of patients suffer from failed back surgery syndrome (FBSS), with 4–9% undergoing revision surgery [ 2 , 3 ].…”