Effect of cyanoacrylate tissue adhesive in postoperative palatal pain management: a systematic review

Escobar, Mario; Pauletto, Patrícia; Benfatti, César Augusto Magalhães; Cruz, Ariádne Cristiane Cabral da; Flores-Mir, Carlos; Henriques, Bruno

doi:10.1007/s00784-020-03683-w

Cited by 20 publications

(16 citation statements)

References 28 publications

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“…Several approaches to lessen patients’ postoperative discomfort have been reported 9,10 . Utilized techniques include using a palatal stent, collagen‐gelatin scaffolds, resorbable gelatin sponge, oxidized cellulose, collagen membranes, medicinal plant extract, cyanoacrylate by itself or in addition to other dressing materials (e.g., Alvogyl, platelet concentrates and platelet rich fibrin [PRF]) 11 .…”

Section: Introductionmentioning

confidence: 99%

“…8 Several approaches to lessen patients' postoperative discomfort have been reported. 9,10 Utilized techniques include using a palatal stent, collagen-gelatin scaffolds, resorbable gelatin sponge, oxidized cellulose, collagen membranes, medicinal plant extract, cyanoacrylate by itself or in addition to other dressing materials (e.g., Alvogyl, platelet concentrates and platelet rich fibrin [PRF]). 11 In a previous randomized clinical trial (RCT), we observed that adding an additional layer of cyanoacrylate over a hemostatic collagen sponge on the palatal wound following FEG was successful in minimizing patients' postoperative discomfort and the need for analgesics.…”

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confidence: 99%

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Patient‐reported outcomes of palatal donor site healing using four different wound dressing modalities following free epithelialized mucosal grafts: A four‐arm randomized controlled clinical trial

Basma

Saleh

Abou‐Arraj

et al. 2022

Journal of Periodontology

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Background The aim of this study was to compare the effects of four different commonly used wound dressings in improving patient reported outcomes (PROMS) after free epithelialized mucosal grafts (FEGs) harvesting. Methods Following 72 FEGs harvesting from 72 patients, patients were assigned into four groups. Control: collagen plug + sutures (CPS); test: collagen plug with cyano‐acrylate (CPC), platelet rich fibrin (PRF) + sutures, or palatal stent only (PS). Patients were observed for 14 days, with evaluation of pain level utilizing the visual analog scale, number of analgesics consumed, need for additional analgesics, amount of swelling, amount of bleeding, activity tolerance, and willingness for retreatment. Results Compared to the control group all test groups indicated significant lower pain perception (P < 0.0001), lower analgesic consumption (P < 0.0001), and higher willingness for retreatment (P < 0.0001), while no statistically significant differences among test groups were observed. There were no statistically significant differences in amount of day‐by‐day swelling, bleeding, and activity tolerance among four groups. Compared to other groups, the PS had the lowest overall pain scores (over the 14‐day period). Palatal thickness, graft length, graft width, and graft thickness did not appear to affect patient morbidity (P > 0.05). Conclusions All interventions significantly decreased pain perception compared to a hemostatic collagen sponge alone over the palatal donor site after FEG surgery. In the first few days after surgery, the use of a palatal stent seemed to be associated with less overall pain, pain pills consumed, and higher willingness of doing the same procedure again.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Patient‐reported outcomes of palatal donor site healing using four different wound dressing modalities following free epithelialized mucosal grafts: A four‐arm randomized controlled clinical trial

Basma

Saleh

Abou‐Arraj

et al. 2022

Journal of Periodontology

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“…A significant between-group difference was found in spontaneous bleeding of the surgical wound during the first 48 h. Ozcan et al [6] and Oladega et al [26] also described a statistically significant difference in postoperative bleeding during the first day postsurgery. However, no difference in bleeding was observed by Stavropoulou et al [14] or by Griffin et al [27], who attributed the bleeding more to trauma produced during the postoperative period than to possible deficiencies of the technique, as also argued by Escobar et al [28]. This discrepancy with the present results may be explained by possible traumas during the post-surgical period, which are more frequent when the bleeding area is not covered a rigid layer, as is the case when cyanoacrylate adhesive is used.…”

Section: Discussionmentioning

confidence: 92%

Comparison between Tissue Adhesive Cyanoacrylate and Suture for Palatal Fibromucosa Healing: A Randomized Controlled Study

et al. 2021

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Cyanoacrylate tissue adhesive is proposed to promote soft tissue healing in oral surgery and minimize complications (pain, inflammation, and bleeding) associated with wound healing by secondary intention. The objective was to compare cyanoacrylate tissue adhesive (test group) with suture (control group) in terms of postoperative complications, operative time, and wound healing in the palatal donor area after harvesting a de-epithelialized gingival graft. A randomized controlled clinical trial was performed in 24 patients randomly assigned to one of two study groups. Data were gathered on wound bleeding, operative time, postoperative pain, inflammation, hyperesthesia, necrosis, and donor area healing time. Operative time was almost 50% shorter in the tissue adhesive cyanoacrylate group, a significant between-group difference (p = 0.003). Spontaneous bleeding in the donor area during the first 24 h was observed in 11.1% of the tissue adhesive cyanoacrylate group versus 88.9% of the suture group—a significant difference. No significant between-group difference was observed in postoperative pain, inflammation, or degree of healing over time. There were no cases of hyperesthesia or wound necrosis. Utilization of tissue adhesive cyanoacrylate rather than suture in palatal de-epithelialized gingival graft harvesting reduces postoperative bleeding during the first 24 h, as well as the operative time.

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“…Positive results have been demonstrated when palatal wound coverage is performed with platelet-rich fibrin [15], ozonated oils [34], topical erythropoietin [35], oral flurbiprofen spray [36], hyaluronic acid [37], and cyanoacrylate [13], among others. Techniques have also been described as alternatives to reduce patient postoperative morbidity.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, strategies to reduce overall patient affliction are currently being investigated [10,11]. They comprise different surgical harvesting techniques and methods of wound closure [12,13]. Additionally, some randomized clinical trials (RCTs) have evaluated epithelialized graft tissue dimensions on patient ailment [11,[14][15][16][17] and have been discussed how to harvest the graft from the palate to minimize patient soreness [9].…”

Section: Introductionmentioning

confidence: 99%

Dimensional Influence of Epithelialized Tissue Graft Harvested From Palate on Postoperative Pain: a Systematic Reviewew

Escobar¹,

Brum²,

Apaza‐Bedoya³

et al. 2022

JOMR

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Objectives:The aim of the present systematic review was to evaluate the dimensional influence of the epithelialized tissue graft harvested from the palate in the postoperative pain. Material and Methods: Research was conducted in electronic databases Cochrane Library, Embase, LILACS, PubMed, Scopus, and Web of Science upwards May 15, 2022. Studies that reported the influence of graft dimensions of palatal epithelized harvesting on postoperative pain were eligible. The evaluation was made using the methodological quality assessment by Joanna Briggs Institute Critical Appraisal Checklist for randomized clinical trials and non-randomized studies and the level of evidence according to GRADE. Results: Four studies were included. The clinical and methodological heterogeneity among studies led to an analysed narrative. The postoperative pain was assessed during the period of 1 to 28 postoperative days. It was determined by using visual analog scale in three studies, while the evaluation was performed indirectly based on analgesics intake in one study. According to three studies, bigger graft sizes were associated with higher postoperative pain. The methodological quality assessment categorized two study as high (one randomized control trial and one non-randomized), and two as moderate (one randomized control trial and one non-randomized). The data was considered moderate. Conclusions: Based on the moderate certainty level, bigger graft sizes of palatal epithelized harvesting appear to promote more postoperative pain. Understanding the postoperative pain as a response to a graft extension may assist some clinical decisions regarding the surgical periodontal and peri-implant planning.

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Effect of cyanoacrylate tissue adhesive in postoperative palatal pain management: a systematic review

Cited by 20 publications

References 28 publications

Patient‐reported outcomes of palatal donor site healing using four different wound dressing modalities following free epithelialized mucosal grafts: A four‐arm randomized controlled clinical trial

Patient‐reported outcomes of palatal donor site healing using four different wound dressing modalities following free epithelialized mucosal grafts: A four‐arm randomized controlled clinical trial

Comparison between Tissue Adhesive Cyanoacrylate and Suture for Palatal Fibromucosa Healing: A Randomized Controlled Study

Dimensional Influence of Epithelialized Tissue Graft Harvested From Palate on Postoperative Pain: a Systematic Reviewew

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