2021
DOI: 10.1096/fasebj.2021.35.s1.01710
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Effect of Cyclooxygenase‐2 Glycosylation on Downstream Expression of E‐Cadherin and b‐Catenin in MCF‐7 Breast Cancer Cells

Abstract: Cyclooxygenases (COXs) are enzymes that catalyze the formation of prostaglandins. Prostaglandins are a class of lipid mediators that can promote inflammation, pain, and fever as well as maintain a variety of normal physiological functions. Cyclooxygenases exist in two forms, COX‐1 and COX‐2, both of which are localized to the luminal membrane of the endoplasmic reticulum. COX‐2 expression is usually induced in response to certain stimuli, such as infection. However, overexpression of COX‐2 has been correlated … Show more

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