2014
DOI: 10.1016/j.ejphar.2014.06.027
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Effect of cyclooxygenase (COX)-2 inhibition on mouse renal interstitial fibrosis

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Cited by 26 publications
(19 citation statements)
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“…Kidney function was estimated through measurement of serum creatinine levels using HPLC method. In accordance with our results, Honma et al (2014) also showed significantly increased serum levels in mice 7 days after UUO. Through the treatment of RLX a significant improvement of kidney function, estimated by decreased serum creatinine levels, was observed in our experiments as well as in previous experiments in RLX –/– mice ( Samuel et al, 2004 ) and a antiglomerular basement membrane model ( McDonald et al, 2003 ), when treated with RLX.…”
Section: Discussionsupporting
confidence: 92%
“…Kidney function was estimated through measurement of serum creatinine levels using HPLC method. In accordance with our results, Honma et al (2014) also showed significantly increased serum levels in mice 7 days after UUO. Through the treatment of RLX a significant improvement of kidney function, estimated by decreased serum creatinine levels, was observed in our experiments as well as in previous experiments in RLX –/– mice ( Samuel et al, 2004 ) and a antiglomerular basement membrane model ( McDonald et al, 2003 ), when treated with RLX.…”
Section: Discussionsupporting
confidence: 92%
“…In contrast to the effect of celecoxib, the COX-2 inhibitor meloxicam has been reported to facilitate fibrosis following UUO [23,24]. The selectivity of meloxicam for COX-2 is less than that of celecoxib [7].…”
Section: Discussionmentioning
confidence: 88%
“…The PG system is similarly an important pharmacological target for the prevention of renal inflammation and fibrosis. Studies have shown that selective COX-2 inhibition ameliorates the progression of renal parenchymal damage and interstitial fibrosis caused by unilateral ureteral obstruction (UUO) [63] , [64] . In addition, we have inhibited COX-2 using a chitosan nanoparticle system delivering anti–COX-2 small interfering RNA (siRNA) that targets COX-2 in only macrophages.…”
Section: Pathophysiological Conditionsmentioning
confidence: 99%