Effect of cycloplegic eye drops on pain after photorefractive keratectomy and corneal collagen cross-linking

Elbedewy, Hazem A; Sabry, Moataz

doi:10.4103/djo.djo_40_19

Cited by 2 publications

(4 citation statements)

References 2 publications

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“…Current evidence indicates that homatropine and cyclopentolate do provide some degree of analgesia for acute corneal pain after PRK and CXL. 14,46,47 Specifically, homatropine (4 times a day) significantly reduced pain scores at 24 hours and 48 hours after PRK as compared with placebo. 47 Cyclopentolate (3 times a day) was similarly reported to significantly decrease pain scores after PRK and CXL.…”

Section: Topical Anticholinergics: Cycloplegicsmentioning

confidence: 96%

“…47 Cyclopentolate (3 times a day) was similarly reported to significantly decrease pain scores after PRK and CXL. 46 A reduction in pain was not observed in the setting of corneal abrasion, using homatropine every 6 hours for 18 hours or homatropine applied once at initial examination of the abrasion. 48,49 It is likely that, in part, this finding reflects the lower degree to which inflammatory-driven pain occurs after mild-to-moderate corneal abrasions, where higher levels of inflammation are likely to occur with PRK and CXL procedures.…”

Section: Topical Anestheticsmentioning

confidence: 98%

“…46,[48][49][50] Expected side effects with the use of cycloplegics include transient blurred vision and photophobia due to loss of accommodation and mydriasis, respectively. 46 Regarding chronic ocular pain, the use of cycloplegics is not mechanistically supported in the setting of neuropathic ocular pain and there is a lack of studies examining their use in this setting. There may, however, be some benefit to their use when chronic ocular pain involves ongoing inflammation that triggers ciliary spasm.…”

Section: Topical Anestheticsmentioning

confidence: 99%

“…Most studies on cycloplegics have not assessed measures of safety; however, when assessed, no adverse effects were noted at the level of the ocular surface. 46,[48][49][50] Expected side effects with the use of cycloplegics include transient blurred vision and photophobia due to loss of accommodation and mydriasis, respectively. 46 Regarding chronic ocular pain, the use of cycloplegics is not mechanistically supported in the setting of neuropathic ocular pain and there is a lack of studies examining their use in this setting.…”

Section: Topical Anestheticsmentioning

confidence: 99%

See 3 more Smart Citations

Topical analgesics for acute corneal pain: current options and emerging therapeutics

Lafreniere

Szczesniak

Courtney

et al. 2023

J Cataract Refract Surg

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Acute corneal pain is a common complaint that causes significant distress to patients and continues to challenge therapeutic avenues for pain management. Current topical treatment options have marked limitations in terms of both efficacy and safety, thus often prompting the adjunctive use of systemic analgesics, including opioids. In general, there have not been extensive advancements in pharmacologic options for the management of corneal pain over the past several decades. Despite this, multiple promising therapeutic avenues exist which hold the potential to transform the ocular pain landscape, including druggable targets within the endocannabinoid system. This review will summarize the current evidence base for topical nonsteroidal anti-inflammatory drugs, anticholinergic agents, and anesthetics before focusing on several potential avenues in the setting of acute corneal pain management, including autologous tear serum, topical opioids and endocannabinoid system modulators.

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Section: Topical Anticholinergics: Cycloplegicsmentioning

confidence: 96%

Section: Topical Anestheticsmentioning

confidence: 98%

Section: Topical Anestheticsmentioning

confidence: 99%

Section: Topical Anestheticsmentioning

confidence: 99%

See 2 more Smart Citations

Topical analgesics for acute corneal pain: current options and emerging therapeutics

Lafreniere

Szczesniak

Courtney

et al. 2023

J Cataract Refract Surg

View full text Add to dashboard Cite

show abstract

Update on Pain Management After Advanced Surface Ablation

Mohammadpour¹,

Heirani²,

Khorrami-Nejad³

et al. 2021

J Refract Surg

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PURPOSE: To provide an update for postoperative pain control strategies to help ophthalmic surgeons establish a more effective management plan for patients who underwent advanced surface ablation surgeries. METHODS: Google Scholar, Scopus, ScienceDirect, and PubMed were the main resources used to search the medical literature. RESULTS: The postoperative cornea's healing process is accompanied by intense pain as the chief complaint in the first days after the operation. Several strategies were developed to relieve postoperative pain after surface ablation procedures. These strategies included different preoperative, intraoperative, and postoperative methods. Considering the preoperative demographic and emotional factors, underlying dry eye, alternative epithelial removal techniques, bandage contact lenses, and topical or oral therapeutic agents are some examples of postoperative pain treatments after surface ablation procedures. CONCLUSIONS: The current review revealed that despite the development of numerous protocols to relieve postoperative pain following surface ablations, the best approach could be a combination of different strategies. In practice, no validated and standardized strategy is available for total elimination of postoperative pain following advanced surface ablation surgeries. [ J Refract Surg . 2021;37(11):782–790.]

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Effect of cycloplegic eye drops on pain after photorefractive keratectomy and corneal collagen cross-linking

Cited by 2 publications

References 2 publications

Topical analgesics for acute corneal pain: current options and emerging therapeutics

Topical analgesics for acute corneal pain: current options and emerging therapeutics

Update on Pain Management After Advanced Surface Ablation

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