Effect of cyclosporine A formulations on bovine corneal absorption:<i>ex-vivo</i>study

Bourlais, C. A. Le; Chevanne, François; Turlin, Bruno; Acar, L.; Zia, Hossein; Sado, P. A.; Needham, Thomas E.; Leverge, R.

doi:10.3109/02652049709033830

Cited by 40 publications

(10 citation statements)

References 24 publications

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“…Extensive studies of ophthalmic delivery systems [67][68][69][70] have shown that, in comparison with the control group, the corneal level of drug concentration was up to 5-fold if encapsulated in nanocapsules.…”

Section: Nanocapsulesmentioning

confidence: 99%

Liposome-Nanogel Structures for Future Pharmaceutical Applications

Казаков¹,

Levón²

2006

CPD

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Nanoparticles have been extensively studied as drug delivery systems. In this review, we focus on a relatively new type of nanoparticles--lipobeads--a liposome-hydrogel assembly as a novel drug delivery system. An appropriate assemblage of spherical hydrogel particles and liposomes combines the properties of both classes of materials and may find a variety of biomedical applications. The bi-compartmental structure of lipobeads is a natural configuration. Thus, the technology of their preparation can be a key step of designing more stable and effective vaccines. Biocompatibility and stability, ability to deliver a broad range of bioactive molecules, environmental responsiveness of both inner nanogel core and external lipid bilayer, and individual specificity of both compartments make the liposome-nanogel design a versatile drug delivery system relevant for all known drug administration routes and suitable for different diseases with possibility of efficient targeting to different organs. New findings on reversible and irreversible aggregation of lipobeads can lead to novel combined drug delivery systems regarding lipobeads as multipurpose containers. The research on hydrogel-liposome submicrometer structures has just begun and fundamental studies on interactions between hydrogels and liposomes are in demand.

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Section: Nanocapsulesmentioning

confidence: 99%

Liposome-Nanogel Structures for Future Pharmaceutical Applications

Казаков¹,

Levón²

2006

CPD

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“…Ocular administration of nanoparticles has been widely investigated as a topical suspended system or a local injectable system for treating various eye disorders, such as glaucoma (41)(42)(43)(44)(45), ocular infections (46)(47)(48), ocular inflammations (49-51) and immune-mediated ocular disorders (52)(53)(54). Drug-loading capacity, drug release rate and biocompatibility of the polymer are of utmost importance for a successful treatment.…”

Section: Nano/microparticlesmentioning

confidence: 99%

New Techniques for Drug Delivery to the Posterior Eye Segment

2010

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Ocular drug delivery has become an increasingly important field of research especially when treating posterior segment diseases of the eye, such as age-related macular degeneration, diabetic retinopathy, posterior uveitis and retinitis. These diseases are the leading causes of vision loss in developed countries which require repeated long-term administration of therapeutic agents. New drugs for the medication of the posterior ocular segment have emerged, but most drugs are delivered by repeated intravitreal injections associated with ocular complications. Advances in ocular drug delivery system research are expected to provide new tools for the treatment of the posterior segment diseases, providing improved drug penetration, prolonged action, higher efficacy, improved safety and less invasive administration, resulting in higher patient compliance. This review provides an insight into the recent progress and trends in ocular drug delivery systems for treating posterior eye segment diseases, with an emphasis on transscleral iontophoresis.

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“…The absorption of cyclosporin A (2) by bovine cornea after 24 h contact with various drug delivery systems containing 1% drug was assessed in an ex vivo study [24]. The different formulations studied were PAA gel, PIBCA nanocapsules, and a combination of both formulations.…”

Section: In Vitro and Ex Vivo Modelsmentioning

confidence: 99%

“…The tolerability of cyclosporin A (2) formulated in different drug delivery systems (i.e., olive oil, PAA gel, PIBCA nanocapsules, and the gel-nanocapsule combination) was assessed in isolated bovine corneas [24]. After exposure to the gel-nanocapsule combination formulation the corneas were found to be histologically normal.…”

Section: In Vitro and Ex Vivo Modelsmentioning

confidence: 99%

Ocular Disposition, Pharmacokinetics, Efficacy and Safety of Nanoparticle-Formulated Ophthalmic Drugs

Bu¹,

Gukasyan²,

Goulet³

et al. 2007

CDM

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Ophthalmic drugs are delivered to ocular tissues predominantly via relatively simple formulations, such as topically dosed water-soluble drug solutions and water-insoluble drug suspensions in ointments. An ideal topical drug delivery system should possess certain desirable properties, such as good corneal and conjunctival penetration, prolonged precorneal residence time, easy instillation, non-irritative and comfortable to minimize lachrymation and reflex blinking, and appropriate rheological properties. In general, ocular efficacy is closely related to ocular drug bioavailability, which may be enhanced by increasing corneal drug penetration and prolonging precorneal drug residence time. To improve ocular bioavailability of topically dosed ophthalmic drugs, a variety of ocular drug delivery systems, such as hydrogels, microparticles, nanoparticles, microemulsions, liposomes and collagen shields, have been designed and investigated. These newer systems may, to some extent, control drug release and maintain therapeutic levels in ocular tissues over a prolonged period of time. This review focuses on the in vitro, ex vivo and in vivo studies of ophthalmic drugs formulated in nanoparticles published over the past two decades. The progress and development issues relating to ocular disposition, pharmacokinetics, efficacy and safety of the nanoparticle-formulated ophthalmic drugs are specifically addressed. Information and discussions summarized in this review are helpful for pharmaceutical scientists to develop better ophthalmic therapeutics.

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Effect of cyclosporine A formulations on bovine corneal absorption:ex-vivostudy

Cited by 40 publications

References 24 publications

Liposome-Nanogel Structures for Future Pharmaceutical Applications

Liposome-Nanogel Structures for Future Pharmaceutical Applications

New Techniques for Drug Delivery to the Posterior Eye Segment

Ocular Disposition, Pharmacokinetics, Efficacy and Safety of Nanoparticle-Formulated Ophthalmic Drugs

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