Effect of cyclosporine, mycophenolic acid, and rapamycin on the proliferation of rat aortic vascular smooth muscle cells: in vitro study

Moon, Jeong Mi; Kim, Y.S; Kim, M.S; Kim, E.H; Kim, H.J; Kim, S.I; Park, Kyong

doi:10.1016/s0041-1345(00)01542-6

Cited by 37 publications

(22 citation statements)

References 5 publications

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“…PSIs may also inhibit proliferation of fibroblasts and smooth muscle cells at least partly through interaction with growth factors, such as, fibroblast growth factor (FGF) (6,7). Through their combined effect on immunity and fibrosis, these agents may, therefore, inhibit CAV development or progression.…”

Section: Introductionmentioning

confidence: 99%

Virtual Histology Assessment of Cardiac Allograft Vasculopathy Following Introduction of Everolimus—Results of a Multicenter Trial

Arora

Erikstad

Ueland

et al. 2012

American Journal of Transplantation

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Clinical trial registry: Clinicaltrials.gov (unique registration number NCT00377962)In this 12-month multicenter Scandinavian study, 78 maintenance heart transplant (HTx) recipients randomized to everolimus with reduced calcineurin inhibitor (CNI) exposure or continued standard CNItherapy underwent matched virtual histology (VH) examination to evaluate morphological progression of cardiac allograft vasculopathy (CAV). Parallel measurement of a range of inflammatory markers was also performed. A similar rate of quantitative CAV progression was observed in the everolimus (n = 30) and standard CNI group (n = 48) (plaque index 1.9 ± 3.8% and 1.6 ± 3.9%, respectively; p = 0.65). However, VH analysis revealed a significant increase in calcified (2.4 ± 4.0 vs. 0.3 ± 3.1%; p = 0.02) and necrotic component (6.5 ± 8.5 vs. 1.1 ± 8.6%; p = 0.01) among everolimus patients compared to controls. The increase in necrotic and calcified components was most prominent in everolimus patients with time since HTx >5.1 years and was accompanied by a significant increase in levels of von Willebrand (vWF) factor (p = 0.04) and vascular cell adhesion molecule (VCAM) (p = 0.03). Conversion to everolimus and reduced CNI is associated with a significant increase in calcified and necrotic intimal components and is more prominent in patients with a longer time since HTx. A significant increase in vWF and VCAM accompanied these qualitative changes and the prognostic implication of these findings requires further investigation.

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Section: Introductionmentioning

confidence: 99%

Virtual Histology Assessment of Cardiac Allograft Vasculopathy Following Introduction of Everolimus—Results of a Multicenter Trial

Arora

Erikstad

Ueland

et al. 2012

American Journal of Transplantation

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“…One of the potential therapeutic agents is rapamycin (Sirolimus), an immunosuppressive agent with marked antiproliferative properties [4,5]. Rapamycin is used as a coating of coronary artery stents and peripheral vascular stents to prevent restenosis [6,7].…”

Section: Introductionmentioning

confidence: 99%

Rapamycin treatment is associated with an increased apoptosis rate in experimental vein grafts☆

Schachner

Oberhuber²,

Zou³

et al. 2005

European Journal of Cardio-Thoracic Surgery

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“…Because lymphocytes rely on the de novo pathway for production of nucleotides, MPA has anti-proliferative effects on these cells by depleting the intracellular guanosine triphosphate pool. In addition to its immunosuppressive potency, MMF attenuates the proliferation of mesangial cells 26 and smooth muscle cells, 24,27 as well as the expression of adhesion molecules in lymphocytes and endothelial cells 28 and antibody production after cardiac transplantation. 29 A number of clinical studies have also demonstrated the efficacy of MMF in patients who received organ transplants.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Mycophenolic Acid Combined With KRP-203, a Novel Immunomodulator, in a Rat Heart Transplantation Model

Suzuki

Takahashi

Morimoto

et al. 2006

The Journal of Heart and Lung Transplantation

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Effect of cyclosporine, mycophenolic acid, and rapamycin on the proliferation of rat aortic vascular smooth muscle cells: in vitro study

Cited by 37 publications

References 5 publications

Virtual Histology Assessment of Cardiac Allograft Vasculopathy Following Introduction of Everolimus—Results of a Multicenter Trial

Virtual Histology Assessment of Cardiac Allograft Vasculopathy Following Introduction of Everolimus—Results of a Multicenter Trial

Rapamycin treatment is associated with an increased apoptosis rate in experimental vein grafts☆

Efficacy of Mycophenolic Acid Combined With KRP-203, a Novel Immunomodulator, in a Rat Heart Transplantation Model

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