Effect of Cydonia oblonga Mill. leaf extracts or captopril on blood pressure and related biomarkers in renal hypertensive rats

Zhou, Wenting; Abdurahman, Adil; Abdusalam, Elzira; Yi-Ming, Wuliya; Abliz, Parida; Aji, Qimangul; Issak, Mehray; Iskandar, Guldiyar; Moore, Nicholas; Umar, Asad

doi:10.1016/j.jep.2014.03.014

Cited by 29 publications

(21 citation statements)

References 29 publications

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“…In these models, we found that SBP increased; LVPWd, LVPWs, IVSd, IVSs, LVW/BW ratio, and cardiomyocyte CSA increased; LVEF decreased; serum NO level decreased; and serum LDH increased as compared to sham-operated rats. These findings are consistent with previous reports on 2K1C hypertensive rat models [ 32 – 34 ]. Cardiomyocyte hypertrophy and cardiac remodeling caused by hypertension led to left ventricular dysfunction [ 34 ].…”

Section: Discussionsupporting

confidence: 94%

The Effects of Aqueous Extract from Nardostachys chinensis Batalin on Blood Pressure and Cardiac Hypertrophy in Two‐Kidney One‐Clip Hypertensive Rats

Rayile

Zhang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Aims The aim of this study was to investigate the effects of the aqueous extract of Nardostachys chinensis Batalin (NCBAE) on blood pressure and cardiac hypertrophy using two-kidney one-clip (2K1C) hypertensive rats. Methods 2K1C rat models were set up by clipping the left renal artery. Sham-operated rats underwent the same surgical procedure except for renal arterial clipping. 2K1C hypertensive rats were orally given NCBAE at doses of 210, 420, and 630 mg·kg−1·d−1 for 6 weeks. Twelve weeks after surgery, rat SBP and echocardiographic parameters were measured, cardiac histopathology was assessed, serum NO and LDH were detected, and the expression of Bcl-2 and caspase-3 of left ventricular tissue was assessed by western blot. Results Treatment with NCBAE resulted in a decrease of SBP, LVPWd, LVPWs, IVSd, IVSs, LVW/BW ratio, and cardiomyocyte CSA, an increase of LVEF, and inhibition of 2K1C-induced reduction in serum NO and elevation of LDH compared with 2K1C group. NCBAE intervention also showed a significant increase of Bcl-2 expression and reduction of cleaved caspase-3 level dose-dependently in left ventricular tissue. Conclusion Our data demonstrate that NCBAE has an antihypertensive property and protective effect on 2K1C-induced cardiac hypertrophy especially at the dose of 630 mg·kg−1·d−1.

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Section: Discussionsupporting

confidence: 94%

The Effects of Aqueous Extract from Nardostachys chinensis Batalin on Blood Pressure and Cardiac Hypertrophy in Two‐Kidney One‐Clip Hypertensive Rats

Rayile

Zhang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…We detected active renin (with 40 kDa) in juxtaglomerular cells, quantified its expression in the kidney and plasma, with a greater detection in the hypertensive group, which was greatly reduced with the treatment. Although, the measurement of aldosterone concentration was not performed, being a limitation of our study, many studies in the literature with the same or higher period of development of renovascular hypertension, showed elevations in plasma renin activity (PRA) and circulating angiotensin II (ANG II) that lead to increased aldosterone [ 38 – 41 ]. Additionally, Nurfaradilla et al [ 42 ] described that in the male Sprague-Dawley 2K1C hypertension model (4 weeks), the plasma renin level, serum angiotensin-converting enzyme (ACE) activity, and plasma angiotensin II level were significantly elevated in the 2R1C group compared to the SHAM group indicating that the increased plasma renin level was likely by increasing renal production in response to loss of perfusion.…”

Section: Discussionmentioning

confidence: 99%

Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension

Matos

Nascimento

Pereira

et al. 2020

International Journal of Hypertension

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Hypertension is a disease classified as primary or secondary, manifested not only by elevation of blood pressure but also involved in structural and functional changes of target organs. Renal artery stenosis is a leading factor of secondary hypertension, and its progress is associated with overactivation of the renin-angiotensin-aldosterone system (RAAS). Aliskiren is a renin inhibiting drug that suppresses RAAS and culminates in decreased renin release, plasma angiotensin II concentration, and inhibition of aldosterone secretion. In this sense, the aim of the present study was to analyze the structural and ultrastructural morphophysiology of the adrenal glomerular zone, after treatment with aliskiren in Wistar rats with 2K1C hypertension. Parameters as structure and ultrastructure of the adrenal glomerular zone, cellular apoptosis, nuclear cell proliferation, and AT1 receptor expression were analyzed by immunostaining and electron microscopy. Our results showed that the hypertensive animals treated with aliskiren presented a reestablishment of AT1 receptor expression and decrease in apoptosis and autophagy. In addition, treatment with aliskiren improves the cell aspects in the adrenal glomerular zone, evidenced by ultrastructural analysis through preserved nuclei and well-developed mitochondria. Therefore, our evidence suggests that aliskiren has a beneficial effect on the adrenal glomerular zone remodeling in animals with renovascular hypertension.

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“…The hypertension induced in this way is dependent on blood volume. Hence, salt and water balance is critically involved in the pathogenesis of Reno vascular hypertension (RVH) (Zhou et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effect of Herbal Mixture as Angiotensin Converting Enzyme Inhibitor in Angiotensin-II Dependent Hypertension

Farieha¹

2019

PVJ

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The effect of herbal mixture of Curcuma longa (CL) and Rauvolfia serpentina (RS) as green ACE inhibitors in Angiotensin-II dependent hypertension was evaluated by measuring the changes in ACE level in blood serum of hypertensive dogs. 2K1C Renovascular Hypertension Model (RVHM) was used to introduce hypertension in dogs. Substantial Hypertension was induced after seven days of renal artery ligation (RAL) with significant increase in the level of ACE in blood serum of spontaneously hypertensive dogs (SHD). Experimental dogs were divided into four groups among them RVH hypertension was induced in the dogs of three groups and fourth group was the normotensive dogs. Hypertensive dogs of one group left untreated while the other two groups treated with herbal mixture and standard drug (Captopril) respectively. The herbal mixture showed significant decrease in Systolic blood pressure (SBP) pressure, diastolic blood pressure (DBP), Pulse rate (PR), and serum ACE level of SHD as compared to Captopril. SBP, DBP and PR were also correlated with hematological parameters. Daily oral administration of herbal mixture resulted in a time-dependent blood pressure and ACE level reduction in SHD, with management of hypertension after nine days treatment. White blood cells (WBC), Lymphocyte (LYM), Mid-sized cells (MID), Granulocyte (GRA), platelet count (PLT), mean corpuscular volume (MPV), platelet distribution width (PDW) and platelet crit (PCT) showed highly significant (P<0.01) positive correlation with SBP, DBP and PR while (red blood cells) RBC showed significant (P<0.05) positive correlation only with SBP and PR. This study demonstrated that the combination of CL and RS effectively reduced blood pressure and heart rate of SHD and this antihypertensive effect is probably due to the reduction of ACE level in blood serum.To Cite This Article: Farieha, Jahan N, Rehman KU and Ali S, 2019. Effect of herbal mixture as Angiotensin converting enzyme inhibitor in Angiotensin-II dependent hypertension. Pak Vet J, 39(1): 25-30. http://dx.

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Effect of Cydonia oblonga Mill. leaf extracts or captopril on blood pressure and related biomarkers in renal hypertensive rats

Cited by 29 publications

References 29 publications

The Effects of Aqueous Extract from Nardostachys chinensis Batalin on Blood Pressure and Cardiac Hypertrophy in Two‐Kidney One‐Clip Hypertensive Rats

The Effects of Aqueous Extract from Nardostachys chinensis Batalin on Blood Pressure and Cardiac Hypertrophy in Two‐Kidney One‐Clip Hypertensive Rats

Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension

Effect of Herbal Mixture as Angiotensin Converting Enzyme Inhibitor in Angiotensin-II Dependent Hypertension

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