Effect of CYP1A1 gene polymorphism and psychological distress on seminal analysis parameters

Singh, Aditi; Koner, Bidhan Chandra; Ray, P. C.; Prasad, Sudha; Jamatia, Elvia; Masroor, Muhammad; Singh, Vijay Kumar

doi:10.1186/s12978-016-0169-1

Cited by 6 publications

(2 citation statements)

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“…Her üç bozukluğa bağlı olarak, göç sonrası sosyo-ekonomik durumun zayıf olması özellikle depresyonla ilişkilidir. [1,7] İnfertil erkeklerde psikolojik stresin etkisi ve sonuçları üzerine çok sayıda çalışma vardır. Özellikle spermlerin motilitesini azalttığı ayrıca morfoloji ve sperm sayısınıda olumsuz etkilediği bildirilmiştir.…”

Section: Discussionunclassified

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Yerli popülasyon ve mülteci hasta gruplarında azospermi oranları ve etkileyen faktörler

Toksöz¹,

Kızılkan²

2019

Androl Bul

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İnfertilite, cinsel yönden aktif ve kontrasepsiyon uygulamayan bir çiftin bir yıl içerisinde gebelik elde edememesi durumu olarak tanımlanır (WHO). Çiftlerin yaklaşık %25'i 1 yıl ABSTRACT OBJECTIVE: In this study we aimed to evaluate the rates of azoospermia in the local population/refugee patient groups and parameters that may have an effect who were applied to our hospital with male infertility. MATERIAL and METHODS: We evaluated 626 patients with male infertility who were diagnosed with azoospermia between January 2017 and July 2018 retrospectively. The patients were divided into two groups as local population and refugees. Refugees were also divided as campers and living outside the camps. Age, serum follicle stimulating hormone, luteinizing hormone, total testosterone levels, scrotal ultrasonography (usg) results, presence of varicocele and varicocelectomy operation were evaluated. RESULTS: The number of azoospermic patients was 12.4% (377) in local population, this number was 17.4% (249) in refugees. The number of azoospermic patients was significantly higher in the refugee patient group compared to the local population group (p<0.05). Although there was a significant difference in terms of azoospermia among refugee patient groups living outside the camps and in the camps, this difference was not statistically significant. There was no statistically significant difference between the ratio of hormone values, scrotal USG results, varicocele presence and varicocelectomy operation in the native population and refugee patient group. CONCLUSION: In our study, we found that azoospermic patients were higher than local population in refugee patient group and it was statistically significant. Although the independent variables were similar in the refugees, the high rates of azoospermia were thought to be due to factors such as nutrition, shelter and stress.

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Section: Discussionunclassified

“…İnfertil erkeklerin %30'unda infertiliteye yol açacak herhangi bir neden bulunamamaktadır. [1] Azospermi, ejakülatta hiç sperm bulunmaması anlamına gelmektedir. Erkeklerin %1'inde, infertilite yakınması olanların ise %10-15'inde azospermi görülmektedir.…”

Section: Anahtar Kelimelerunclassified

Yerli popülasyon ve mülteci hasta gruplarında azospermi oranları ve etkileyen faktörler

Toksöz¹,

Kızılkan²

2019

Androl Bul

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Male Reproductive Functions Disrupted by Pharmacological Agents

Drobnis

Nangia

2017

Impacts of Medications on Male Fertility

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In this chapter, we review the male reproductive functions disrupted by medications. Medications can affect the hypothalamic-pituitary-gonad axis, acting as endocrine disrupting chemicals (EDCs). Disturbances may be directly at androgen receptors, modifying the activity of endogenous androgens at the target tissue, or may disrupt feedback loops at the hypothalamus or pituitary resulting in modification of gonadotropin release. Impaired testosterone production and/or spermatogenesis result. Other EDC activities can be indirect via effects on levels of prolactin (PRL), estrogen, cortisol, thyroid hormone, or sex hormone binding globulin (SHBG). Appropriate regulation of these hormones and SHBG are essential for normal reproductive function. An increase in circulating PRL levels is a common adverse medication effect. The consequence is lower gonadotropin and testosterone secretion. Drugs can also have direct toxicity on the seminiferous tubule epithelium, including effects on Leydig cells, Sertoli cells, or germ cells. In some cases, spermatogenesis is severely impaired. After leaving the testis, sperm spend a week or more in the epididymis. It is clear from the timing of some drug effects that sperm are damaged during epididymal transit. There can also be impairment of the ejaculatory reflex, resulting in alterations of emission or expulsion of semen. Even after ejaculation, exposure to seminal plasma can alter sperm function, and some drugs may affect sperm at this stage. The most critical effects on male reproduction are decreased fertility and/or health effects on offspring. These endpoints have received little research attention. Another consideration is the metabolism of drugs. Medications may become more toxic if metabolic systems are suboptimal due to comorbid conditions.

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