Effect of cytidine diphosphate choline on growth hormone and prolactin secretion in man.

Matsuoka, Tetsuro; Kawanaka, Masahiro; Nagai, Kiyoyasu

doi:10.1507/endocrj1954.25.55

Cited by 8 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CDP-choline administration resulted in an increase in basal GH secretion as well as greatly enhanced somatotrope responsiveness to GHRH. These data extend previous reports which documented a stimulatory effect of CDP-choline on basal GH secretion in young normal subjects (27). The precise mechanism by which CDP-choline increased GHRH-stimulated GH responses is still unclear, since CDP-choline mediates several other biologic functions.…”

Section: Discussionsupporting

confidence: 89%

Effects of cytidine 5'-diphosphocholine administration on basal and growth hormone-releasing hormone-induced growth hormone secretion in elderly subjects

Ceda

Ceresini²,

Denti³

et al. 1991

Acta Endocrinologica

View full text Add to dashboard Cite

The basal and GH-releasing hormone-stimulated secretion of GH declines in the elderly. We tested the ability of cytidine 5'-diphosphocholine, a drug used in the treatment of stroke and Parkinson's disease, to alter GH secretion in 11 healthy elderly volunteers, aged 69\ x=r eq-\ 84. Each subject received an iv infusion of 2 g of cytidine 5'-diphosphocholine or normal saline. GHRH and TRH were also administered during cytidine 5'diphosphocholine infusions. The infusion of cytidine 5'-diphosphocholine induced a 4-fold (p<0.05) increase in serum GH levels over basal values. A small increase in GH was seen after GHRH administration. However, the addition of GHRH to the cytidine 5'-diphosphocholine infusion resulted in a GH response which was significantly greater than that seen after GHRH alone; the integrated concentration of GH was more than 2-fold greater in the cytidine 5'-diphosphocholine treated group (706.85\m=+-\ 185.1 vs 248.9\m=+-\61.4\g=m\g \ m=. \ l \ m=-\ 1\ m=. \ (120 mi n)\m=-\1; p=0.01). The PRL and TSH responses to TRH were not significantly affected by cytidine 5'-diphosphocholine infusion, indicating that dopaminergic mechanisms are not involved. These studies demonstrate that cytidine 5'-diphosphocholine can enhance basal and GHRH-stimulated GH release in the elderly, but the mechanism of action of the drug remains unclear.Numerous studies have documented significant changes in GH secretion in aging experimental an¬ imals and in human subjects. Decreased pulsatile secretion of GH (1), a reduced ability of GHRH to release GH both in vivo and in vitro from pituitary cells in primary cultures (2), and a reduced pituitary content of GH and GH mRNA (3,4) have been reported in aged rats. Most, but not all (5), studies have confirmed that GH secretion is impaired in elderly humans. The number of sleep-related GH secretory pulses decreases in most people over 50 years of age (6,7), and there is an age-related de¬ cline in GHRH-induced GH secretion (8). The serum GH-binding protein also declines in the eld¬ erly (9).The etiology of impaired GH secretion in aging remains unclear. Alterations in the synthesis or re¬ lease of GHRH or somatostatin have been impli¬ cated, but remain unproven. Cholinergic agonists can inhibit hypothalamic somatostatin release (10) and thereby modulate GH secretion (11-13). Acti¬ vation of cholinergic receptors by the anticholinesterase pyridostigmine has been shown to restore GH responsiveness to GHRH in obese individuals (14-15) and in normal subjects (16,17). Brain acetylcholine synthesis may decline with aging (18), and it is possible that hypothalamic somatostatin tone is increased, leading to the relative hyposomatotropinemia of old age. Since dopamine stim¬ ulates GH release (19), it is also possible that de¬ creased hypothalamic dopaminergic tone could lead to decreased GH release.Cytidine 5'-diphosphocholine (CDP-choline) is a parenteral medication which has been used as a cerebral vasodilator in elderly patients (20). It has also been used in patients with stroke and Pa...

show abstract

Section: Discussionsupporting

confidence: 89%

Effects of cytidine 5'-diphosphocholine administration on basal and growth hormone-releasing hormone-induced growth hormone secretion in elderly subjects

Ceda

Ceresini²,

Denti³

et al. 1991

Acta Endocrinologica

View full text Add to dashboard Cite

show abstract

“…Many studies have shown the effect of citicoline in the treatment of the so-called senile cerebral involution, decreasing its characteristic symptoms [228][229][230][231][232][233][234][235][236][237][238][239][240], especially on memory evaluated by means of various cognitive scales. Other benefits reflected in these studies include improvements in cooperation and capacity of relationship to the environment, and reducing dosage of psychoactive drugs routinely used in psychogeriatrics, with an excellent safety profile.…”

Section: Clinical Studiesmentioning

confidence: 99%

Citicoline in the Treatment of Cognitive Impairment

Secades¹

2019

J Neurol Exp Neurosci

View full text Add to dashboard Cite

Vascular cognitive impairment is a process which is more frequent in patients with cardiovascular risk factors. The etiology of this kind of impairment could be related to different types of cerebrovascular disorders, given that silent cerebral infarctions or microinfarcts, correlated with small vessel disease, are one of the principal etiologies. Microinfarcts, associated with small vessel diseases, should be considered one of the possible causes of clinical suspicion in patients with cardiovascular risk factors who are asking for help for cognitive complaints. Among the proposed treatments for cognitive impairment there is citicoline. This is an updated review of the possible use of citicoline in the treatment of cognitive impairment.

show abstract

“…June 1980 of GH (Hoyte and Martin, 1975;Molinatti et al, 1976). The inhibitory effect on the PRL secreting system basally (Matsuoka et al, 1978) or after stimulation with sulpiride (Salvadorini et al, 1978) appears to confirm the stimulating effect of CDP-choline on the dopaminergic mediation. We therefore cannot exclude the possibility that the effect of the CDP-choline on GH was induced by other more general activation of nervous structures because CDP-choline is known to stimulate multiple enzimatic activity (Shimamoto and Arakami, 1975) through a generic series of phenomena of the phospholipid biogenesis.…”

Section: Discussionmentioning

confidence: 52%

“…Actually it is impossible to determine the mechanism responsible for the action of CDP-choline in reference to the release of GH. It has been thought that the stimulating effect could be realized through the stimulation of the dopaminergic mediation Salvadorini et al, 1975;Matsuoka et al, 1978) from the moment that on an experimental basis the CDP-choline action induces an increase in the cerebral content of dopamine through a stimulation of the biosynthesis carried out in the substantia nigra (Kobayashi, 1972). This action explains the efficiency of CDP-choline in the treatment of Parkinson's disease (Manaka dopaminergic system remains deficient (Ehringer and Hornykiewicz, 1960).…”

Section: Discussionmentioning

confidence: 99%

Effect of cytidine diphosphate choline on growth hormone secretion in patients with brain or pituitary lesions.

Salvadorini¹,

Saba²,

Forli

et al. 1980

Endocrinol Japon

View full text Add to dashboard Cite

Plasma GH levels basally and after CDP-Choline (300mg) i. v. administration were evaluated by radioimmunoassay in patients with brain lesions variously located (frontal lobe, temporal lobe or hypothalamus) as well asinsubjects with pituitary lesions. The results were statistically analyzed and compared with those obtained in normal subjects.A lack of response to CDP-Choline was observedin patients with pituitary adenomas or hypothalamic lesions. The GH response was delayed in patients with frontal lobe diseases. On the basis of the results obtained, we discuss the role of the different central nervous structures on the control of the GH activating system.

show abstract

Effect of cytidine diphosphate choline on growth hormone and prolactin secretion in man.

Cited by 8 publications

References 6 publications

Effects of cytidine 5'-diphosphocholine administration on basal and growth hormone-releasing hormone-induced growth hormone secretion in elderly subjects

Effects of cytidine 5'-diphosphocholine administration on basal and growth hormone-releasing hormone-induced growth hormone secretion in elderly subjects

Citicoline in the Treatment of Cognitive Impairment

Effect of cytidine diphosphate choline on growth hormone secretion in patients with brain or pituitary lesions.

Contact Info

Product

Resources

About