Effect of cytochrome c peroxidase on corneal epithelial healing process after photorefractive keratectomy

Cytochrome c (Cc) and cytochrome c peroxidase (CcP) form a physiological complex in the inter-membrane space of yeast mitochondria, where CcP reduces hydrogen peroxide to water using the electrons provided by ferrous Cc. The Cc-CcP system has been a popular choice of study of interprotein biological electron transfer (ET) and in understanding dynamics within a protein-protein complex. In this review we have charted seven decades of research beginning with the discovery of CcP and leading to the latest functional and structural work, which has clarified the mechanism of the intermolecular ET, addressed the putative functional role of a low-affinity binding site, and identified lowly-populated intermediates on the energy landscape of complex formation. Despite the remarkable attention bestowed on this complex, a number of outstanding issues remain to be settled on the way to a complete understanding of Cc-CcP interaction.

show abstract

Laser Literature Watch

2006

Photomedicine and Laser Surgery

View full text Add to dashboard Cite

Effect of cytochrome c peroxidase on corneal epithelial healing process after photorefractive keratectomy

Abstract: These data suggest that cytochrome c peroxidase significantly accelerates epithelial healing after PRK. Further clinical study should be performed to prove the results obtained in this pilot study and the long-term efficacy of cytochrome c peroxidase to prevent corneal haze.

Cited by 5 publications

References 18 publications

Minimally Invasive Refractive Surgery

Minimally Invasive Refractive Surgery

The complex of cytochrome c and cytochrome c peroxidase: The end of the road?

Laser Literature Watch

Contact Info

Product

Resources

About