Effect of cytokine gene polymorphism on histological activity index, viral load and response to treatment in patients with chronic hepatitis C genotype 3

Abbas, Zaigham; Moatter, Tariq; Hussainy, Akber; Jafri, Wasim

doi:10.3748/wjg.v11.i42.6656

Cited by 77 publications

(58 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In accordance with our findings, some significant associations with regard to IL-18 and IFN-c polymorphisms have been observed [30,35]. However, other studies revealed opposing results [36,37]. These contradictory results could be partly explained by the extreme complexity in the cytokine network related to the intricate interactions of cytokines by which they induce or suppress their own synthesis or that of other cytokines, and antagonize or synergize with each other in many different and often redundant ways.…”

Section: Introductionsupporting

confidence: 53%

“…In line with our finding, a large scale study conducted by Dai et al [35] on Taiwanese HCVinfected patients described a significant increase of IFN-c ?874T allele in cirrhotic patients. Nevertheless, other studies failed to demonstrate any association between T allele and hepatitis C severity [36,37]. In reality, in multifactorial diseases like HCV infection, where the host, the pathogen and the environmental factors all contribute to disease outcome, genetic association studies focused on a single polymorphism are often weak and non-informative.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Combined effect of pro- and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients

et al. 2011

View full text Add to dashboard Cite

Section: Introductionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Combined effect of pro- and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients

et al. 2011

View full text Add to dashboard Cite

“…The analysis of IL-10 gene polymorphisms indicated a variation between the proinflammatory and anti-inflammatory cytokine responses, which may have resulted in immunodeficiency to HCV infection in Pakistan [21]. Meanwhile, no significant correlation has been found between SNPs of IL-10 and histological activity index in HCV patients [22]. Accordingly, in the current study, we further investigated the possible SNPs in IL-10 and IL-4 that may occur in samples collected from Egyptian patients.…”

Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphisms of interleukins associated with hepatitis C virus infection in Egypt

Khalil

Arfa

El-Masrey

et al. 2017

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Hepatitis C is a liver disease caused by the hepatitis C virus (HCV). It can cause both acute and chronic hepatitis infection. Based on secretion of required cytokines upon infection, HCV can improve its own RNA and successfully complete the replication cycle. Importantly, single nucleotide polymorphisms (SNPs) are the most common type of genetic variation and have been found to play a critical role in modulation of cellular cytokine production and interaction. Methodology: A total of 100 blood samples were obtained from HCV patients, and 120 samples were obtained from healthy individuals who served as controls. SNPs of interleukin-10/592 (IL-10/592) and IL-4/589 were investigated for possible connection with HCV infection. Relative expression of IL-4, IL-6, and IL-10 were detected using real-time polymerase chain reaction and enzyme-linked immunosorbent assay Results: The polymorphisms of IL-10 revealed a high rate of mutant genotype CC within the location IL-10/592 in HCV patients and controls, which resulted in low secretion of IL-10. Interestingly, the findings here demonstrate a positive association between HCV load of viremia and the mutant genotype IL-4-589/TT accompanied with low expression IL-4 in comparison with IL-6 expression. Conclusions: These data suggest that the expression of IL-4 is inversely proportional to HCV load of viremia, and this connection is due to the high level of mutant genotype IL-4-589/TT in infected patients located in gene promoter and inhibits gene expression.

show abstract

“…The result showed that the genotype distributions of TNF-α gene (−238 and −308) in the Chinese HD patients were similar to those in the general Chinese population, 15 but that the frequencies of A alleles and AA genotypes of TNF-α gene (−238 and −308) were lower than those in Pakistan and Ireland population. 30,31 Furthermore, in this study, no link was identified between the two SNPs of TNF-α promoter gene and susceptibility to HCV infection or the viral persistent infection in Chinese HD patients. The discrepancy above could be contributed to the special HD population in our study, who were different from the general population, since HD patients infected with HCV will be under the triple influence of uremia, the HD procedure, and the HCV infection itself.…”

Section: Discussionmentioning

confidence: 86%

Tumor Necrosis Factor-α Promoter Gene Polymorphisms Are Not Associated with Hepatitis C Virus Infection in Chinese Hemodialysis Patients

Zhang

Zhu

et al. 2011

Renal Failure

View full text Add to dashboard Cite

Background and aims: The aim of this study was to investigate the possible influence of tumor necrosis factor-α (TNF-α) gene promoter polymorphisms on the hepatitis C virus (HCV) infection in Chinese hemodialysis (HD) patients. Methods: A total of 884 HD patients from 14 HD centers in south China were investigated. The TNF-α gene promoter polymorphisms at positions 238 and 308 of the patients were detected by the polymerase chain reaction (PCR)-restriction fragment length polymorphism method. Results: Among the 884 patients, 176 (19.9%) were anti-HCV (+), and 142 (80.7%) of the anti-HCV (+) patients became chronically infected. The anti-HCV (+) patients showed longer duration of HD, higher rate of blood transfusion, kidney transplantation, and dialyzer reuse, compared with the anti-HCV (−) patients. However, the distributions of TNF-α −238 and −308 alleles and genotypes had no significant differences between the anti-HCV (+) and the anti-HCV (−) patients (p > 0.05). And the frequencies of the above alleles and genotypes were also approximately equally distributed in the persistent infection and in the viral clearance HD patients (p > 0.05). Conclusions: This study did not suggest that the TNF-α −238 and −308 polymorphisms had influence on the infection of HCV in Chinese HD patients.

show abstract

Effect of cytokine gene polymorphism on histological activity index, viral load and response to treatment in patients with chronic hepatitis C genotype 3

Cited by 77 publications

References 48 publications

Combined effect of pro- and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients

Combined effect of pro- and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients

Single nucleotide polymorphisms of interleukins associated with hepatitis C virus infection in Egypt

Tumor Necrosis Factor-α Promoter Gene Polymorphisms Are Not Associated with Hepatitis C Virus Infection in Chinese Hemodialysis Patients

Contact Info

Product

Resources

About