Effect of D‐pinitol on MK‐801‐induced schizophrenia‐like behaviors in mice

Abstract

Schizophrenia is a chronic brain disorder characterized by positive symptoms (delusions or hallucinations), negative symptoms (impaired motivation or social withdrawal), and cognitive impairment. In the present study, we explored whether D‐pinitol could ameliorate schizophrenia‐like behaviors induced by MK‐801, an N‐methyl‐D‐aspartate receptor antagonist. Acoustic startle response test was conducted to evaluate the effects of D‐pinitol on sensorimotor gating function. Social interaction and novel object recognition tests were employed to measure the impact of D‐pinitol on social behavior and cognitive function, respectively. Additionally, we examined whether D‐pinitol affects motor coordination. Western blotting was conducted to investigate the mechanism of action of D‐pinitol. Single administration of D‐pinitol at 30, 100, or 300 mg/kg improved the sensorimotor gating deficit induced by MK801 in the acoustic startle response test. D‐Pinitol also reversed social behavior deficits and cognitive impairments induced by MK‐801 without causing any motor coordination deficits. Furthermore, D‐pinitol reversed increased expression levels of pNF‐kB induced by MK‐801 treatment and consequently increased expression levels of TNF‐α and IL‐6 in the prefrontal cortex. These results suggest that D‐pinitol could be a potential candidate for treating sensorimotor gating deficits and cognitive impairment observed in schizophrenia by down‐regulating transcription factor NF‐κB and pro‐inflammatory cytokines in the prefrontal cortex.

D-Pinitol extends antioxidant activity and longevity of Caenorhabditis elegans via insulin-like signaling pathway

“…D-Pinitol, a trimethyl analogue of DCI, is widely present in the owers and leaves of Pinus species, legumes, and many other plants and acts like insulin [41]. D-Pinitol has been reported to treat schizophrenia in mice by down-regulating the transcription factor NF-κB and proin ammatory cytokines in the prefrontal cortex [42]. Our previous studies have shown that DCI can enhance the antioxidant capacity and health lifespan of C. elegans, and delay the development of neurodegenerative diseases in C. elegans [16].…”

Advanced UPLC-MS/MS Method for the Quantification of SIPI6398 in Rat Plasma and Its Pharmacokinetic Characterization

“…It is also a responsibility and challenge that medical professionals must face. Schizophrenia is a serious mental illness characterized mainly by positive symptoms, negative symptoms, and cognitive deficits [ 5 , 6 ]. While anti-schizophrenia medications currently on the market can relieve positive and negative symptoms, they cannot effectively combat cognitive impairment, often leading to more serious side effects.…”