Effect of d-serine on a delayed match-to-place task for the water maze

Stouffer, Eric M.; Petri, Herbert L.; Devan, Bryan D.

doi:10.1016/j.bbr.2003.10.008

Cited by 9 publications

(7 citation statements)

References 38 publications

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“…This suggests, in line with a broad pattern of procognitive properties in rodents (Andersen et al 2002;Jones et al 2004;Stouffer et al 2004), that partial agonists might improve deficits in cognitive-attentional function shown by psychotic patients. Unfortunately, actions of partial agonists have not as yet been described in protocols of chronic PCP administration and neonatal hippocampal lesions.…”

Section: Actions Of Glycine B Receptor Ligands and Gris In Models Of mentioning

confidence: 64%

N-Methyl-d-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives

2005

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Reduced activity at NMDA receptors is implicated in the aetiology of schizophrenia. Correspondingly, drugs that (directly or indirectly) increase activity at Glycine(B) sites may be of use as adjuncts to other classes of antipsychotic agent. However, there is an urgent need for broader clinical evaluation of this possibility, and, to date, there is no evidence that stimulation of Glycine(B) sites alone improves psychotic states.

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Section: Actions Of Glycine B Receptor Ligands and Gris In Models Of mentioning

confidence: 64%

N-Methyl-d-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives

2005

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“…The dose of D-serine employed in these studies with LgA rats (100mg/kg) was selected based upon our prior experience in the reinstatement of cocaine-seeking behavior in ShA rats (Kelamangalath et al, 2007 & 2009), reports of D-serine effects on other forms of learning and memory (Stouffer EM et al, 2004), the pharmacokinetic parameters of D-serine (Hashimoto and Chiba, 2004; Smith et al, 2009), and the known sensitivity of rats to D-serine induced nephrotoxicity (Williams et al, 2003). Although it is often administered at much higher levels (600–800mg/kg) to demonstrate effects on learning/memory performance (Duffy et al, 2008; Karasawaa et al, 2008), we have not tested such larger doses and the assessment of lower doses of D-serine on the reinstatement of drug-seeking is a future topic of study.…”

Section: Discussionmentioning

confidence: 99%

D-serine treatment reduces cocaine-primed reinstatement in rats following extended access to cocaine self-administration

Kelamangalath¹,

Wagner²

2010

Neuroscience

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The most intractable feature of drug addiction is the high rate of relapse, even following extended periods of abstinence from drug-taking. Evidence suggests that allowing rats extended access to cocaine self-administration leads to behavioral characteristics in these animals that are consistent with the development of addiction in humans. In the current study, rats were allowed to selfadminister cocaine over a total of 22 daily sessions, the final 7 of which were long-access (LgA) sessions of 6 hours duration. Assessments of reinstatement of drug-seeking behavior were made following reintroduction to the drug-taking environment and noncontingent priming with either CS or cocaine in both extinguished and abstinent subject groups. Three separate groups of rats were treated with either saline or D-serine (100mg/kg i.p.) administered 2 hrs prior to, or immediately following, each extinction training session. Saline-treated LgA rats were resistant to the effects of extinction training to reduce noncontingent priming of reinstatement of drug-seeking behavior with either CS or cocaine. In contrast, treatment with D-serine either before or immediately following the sessions resulted in a significant enhancement in the ability of extinction training to reduce cocaine-primed reinstatement of drug-seeking behavior. These results suggest that D-serine can act to enhance the consolidation of extinction learning in LgA rats, and is therefore a promising adjunctive agent along with behavioral therapy for the treatment of cocaine addiction.The development of an effective treatment regimen for the state of addiction to psychostimulants such as cocaine and amphetamines has proved to be problematic, and currently there is no FDA approved treatment for this condition. A prominent feature of addiction is the propensity for relapse, and craving is thought to be a contributing factor for this component of the disease (Jaffe et al., 1989;Ehrman et al., 1992). One therapeutic approach showing efficacy involves behavioral therapy, including the attempt to restructure past experiences and learn new behaviors that would decrease the frequency and/or severity of relapse in individuals attempting to remain abstinent (Dutra et al., 2008;Waldron and Turner, 2008). Enhancing the effectiveness of such psychosocial treatments through the use of adjunctive pharmacotherapy such as cognitive enhancement is therefore a reasonable

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“…In addition, D-serine administration improves social memory in rats (Shimazaki et al 2010). However, most of the above cited studies used doses of 600-1,300 mg/kg (with the exception of that by Stouffer et al 2004, which used 100 mg/kg), far above the range shown to be effective in clinical trials with schizophrenia patients (30-120 mg/kg). Nevertheless, studies of functional magnetic resonance imaging in rodents have shown that parenteral administration of 50 mg/kg of D-serine is enough to induce an increase in hippocampal activation (Panizzutti et al 2005).…”

Section: Introductionmentioning

confidence: 87%

“…Exogenous administration of D-serine leads to improvements in specific features of spatial memory in the Morris water maze, such as reversal learning (Duffy et al 2008), probe test retrieval (Zhang et al 2008), and day-to-day savings in the delayed-match-to-place version of the task (Stouffer et al 2004). In addition, D-serine administration improves social memory in rats (Shimazaki et al 2010).…”

Section: Introductionmentioning

confidence: 98%