Effect of Daidzein 120 Mg Supplementation to Menopausal Symptoms and Quality of Life in Non Equol Producer Women

Natadisastra, Muharam; Budiman, B.; Rachman, Ichramsjah A.; Nirmalasari, Rully Ayu

doi:10.22159/ajpcr.2016.v9s3.14023

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…These results are in line with studies in sheep that supplementation with Selenium 0.15 mg/kg increased serum Se levels linearly with increasing duration of experimental feeding for 30; 60; and 90 days. 21 Similar results were reported that 12 weeks of supplementation with 400 mg Q10 and 200 g selenium per day in women aged 58 years significantly increased serum Q10 and selenium levels compared with placebo [15]. In this research, there was no correlation between selenium levels and menopausal complaints based on MENQOL on all disorder aspects both before and after selenium administration.…”

Section: Discussionsupporting

confidence: 73%

Selenium Levels based on Various Menopause Complaints Assessed by Menopause-specific Quality of Life Questionnaire before and after Selenium Intervention

Hisworo

Siregar²,

Pasaribu³

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Menopausal symptoms can greatly affect a woman’s personal, social, and work life. Selenium functions as a cofactor for glutathione peroxidase and helps minimize oxidative damage through cellular metabolism in postmenopausal women when estradiol production decreases, antioxidant protection is lost and therefore oxidative stress is increased. AIM: The aim of the study was to evaluated effect of selenium supplementation on selenium levels based on menopausal complaints assessed by menopause-specific quality of life questionnaire (MENQOL). MATERIALS AND METHODS: This research is an analytical study with quasi-experimental pre-test and post-test one group only design. The research was conducted on all postmenopausal women in Medan who were aged >51-years-old and met inclusion and exclusion criteria. The research subjects underwent blood tests to assess serum selenium levels. If data were normally distributed, dependent T test will be used, while if data were not normally distributed, Wilcoxon test will be used. The analysis results were stated to be significant with p < 0.05. RESULTS: Mean selenium serum levels before selenium administration were 93.20 ± 17.253 μg/L which increased to 132.12 ± 19.866 μg/L after selenium administration. Comparison test results of selenium levels before and after administration found p = 0.000 (p < 0.05), which means there was a significant difference of selenium serum levels before and after selenium administration. Besides that, there were no significant scores difference in aspects of vasomotor disorders (p = 1.000 [p > 0.05]), psychosocial disorders (p = 0.090 [p > 0.05]), physical disorders (p = 0.323 [p > 0.05]), and sexual disorders (p = 0.959 [p > 0.05]) between before and after selenium administration. CONCLUSION: Total MENQOL scores and complaints based on aspects of vasomotor, psychosocial, physical, and sexual disturbances did not show statistically significant changes after administration selenium tablets 100 mcg/day for 7 days.

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Section: Discussionsupporting

confidence: 73%

Selenium Levels based on Various Menopause Complaints Assessed by Menopause-specific Quality of Life Questionnaire before and after Selenium Intervention

Hisworo

Siregar²,

Pasaribu³

et al. 2022

Open Access Maced J Med Sci

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“…There is a need to treat depression by taking antidepressants. Besides psychological factors, several behavioural and environmental factors also raise the problem of sexual dysfunction which includes conditions like obesity, overweight, physical inactivity, (Muharam et al, 2016) etc. Obese women are more likely to have more severe and a significant number of sexual problems (Lewis et al, 2010).…”

Section: Risk Factormentioning

confidence: 99%

Systemic Review: Sexual Dysfunction in Women with type 2 Diabetes Mellitus

Kumar

Gera

Arora

et al. 2018

JPTRM

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Diabetes would not just have a high blood glucose level in the individual body, yet these days diabetes likewise goes with numerous other organic issues like hypertension, feeble the myocardial layer working, sexual broke, and so on. These are some real issue which is these days joined by diabetes to a person’s body. Guys are for the most part being determined to have the sexual broke issue, guys, as well as experience a sexual broke issue. As similarly we may see less clinical examinations, including sexual broke issues looked for the sort two diabetic ladies. The primary goal of this article is to illuminate the situation that females proceed with much trouble with regards to the sexual broke Complication that might be physiological or neurotic if there should arise an occurrence of sorting two diabetes in ladies. It chiefly involves the useful extent of females like sexual drive, excitement, vaginal grease, Orgasm and general fulfilment space. Talking about the treatmentaccess of the ailment in the analyti way for it, Diabetes essentially hinders the sexual execution of Diabetic Women. Determinants of sexual ability incorporate age and extent of diabetes.

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“…Genistein and daidzein were able to suppress bone loss too [11]. In non-equol producer women, supplementation of daidzein did not significantly decrease the menopausal symptoms nor improve their quality of life [12]. Isoflavones are also able to improve cognitive function through the protective mechanism of the nervous system [13].…”

Section: Introductionmentioning

confidence: 99%

Fermentation of Soybean Seeds Using Rhizopus Oligosporus for Tempeh Production and Standardization Based on Isoflavones Content

et al. 2022

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Objective: To determine the best temperature and time of fermentation for making soybean (Glycine max (L.) Merril) tempeh seeds with high content of isoflavones. Methods: Five varieties of soybean seeds, Devon-1, Dena-1, Dega-1, Anjasmoro, and Argomulyo, were determined for their isoflavones content using an Ultraviolet (UV) spectrophotometer. A variety containing the highest isoflavones was washed, boiled, peeled, then mixed with tempeh starter (Rhizopus oligosporus culture) at 1 g/kg. The mixture was then poured into plastic bags and flattened with two centimeters of thickness. Fermentation in three conditions: (a) ambient temperature (27-32 °C) without air circulation, (b) 27±0.5 °C, and (c) 30±0.5 °C both with air circulation. The inner temperature, ripening time, and rotting time was recorded. The total isoflavones content was measured every 6 h. Results: The variety of Devon-1 has the highest content of isoflavones (0.112% w/w). Fermentation in condition (a) caused the tempeh too hot(42 °C) and rotted at the 42nd h. Condition (b) produced the best tempeh, ripening at the inner peak temperature (32.5 °C) at the 32nd h; and rotted after the 100th h. Condition (c) produced good tempeh; the ripening occurred at the 31st h at 33 °C and rotted after the 113th h. Tempeh that was produced with condition (b) at the 72nd h has the highest content of isoflavones (0.089% w/w). Conclusion: Fermentation at 27±0.5 °C with air circulation for 72 h produced tempeh with the highest isoflavones content (0.089% w/w), but decrease about 20% compared to its content in seeds (0.112% w/w).

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Effect of Daidzein 120 Mg Supplementation to Menopausal Symptoms and Quality of Life in Non Equol Producer Women

Cited by 5 publications

References 17 publications

Selenium Levels based on Various Menopause Complaints Assessed by Menopause-specific Quality of Life Questionnaire before and after Selenium Intervention

Selenium Levels based on Various Menopause Complaints Assessed by Menopause-specific Quality of Life Questionnaire before and after Selenium Intervention

Systemic Review: Sexual Dysfunction in Women with type 2 Diabetes Mellitus

Fermentation of Soybean Seeds Using Rhizopus Oligosporus for Tempeh Production and Standardization Based on Isoflavones Content

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