Effect of daily consumption of probiotic yoghurt on insulin resistance in pregnant women: a randomized controlled trial

Asemi, Zatollah; Samimi, Mansooreh; Tabassi, Zohreh; Rad, M Naghibi; Foroushani, Abbas Rahimi; Khorammian, H.; Esmaillzadeh, Ahmad

doi:10.1038/ejcn.2012.189

Cited by 145 publications

(115 citation statements)

References 30 publications

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“…lactis Bb12 had no effect on blood pressure. Our findings of lack of effect are supported by results of other randomised controlled trials which supplemented with the same combination of probiotic strains [4,29]. As the effects of probiotic bacteria are highly strain specific [17], it is not surprising that studies which supplemented with different probiotic strains and species found different results.…”

Section: Discussionsupporting

confidence: 77%

The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomised controlled trial

Ivey

Hodgson

Kerr

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

137

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Section: Discussionsupporting

confidence: 77%

The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomised controlled trial

Ivey

Hodgson

Kerr

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

137

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“…Furthermore, a significant decrease in serum insulin levels in our previous study in diabetic patients was seen after administration of a synbiotic food containing L. sporogenes (27 × 10 7 CFU) and 1.08 g inulin for 6 weeks compared to the control food [19]. The same findings were reported among type 2 diabetic patients who received L. acidophilus for 4 weeks [29], among patients with T2DM who received multispecies probiotic supplements for 8 weeks [20], and among pregnant women who received 2 strains of L. acidophilus and Bifidobacterium animalis with a total of minimum 1 × 10 7 CFU for 9 weeks [30]. However, some researchers did not find such beneficial effects.…”

Section: Discussionsupporting

confidence: 67%

Effects of Daily Consumption of Synbiotic Bread on Insulin Metabolism and Serum High-Sensitivity C-Reactive Protein among Diabetic Patients: A Double-Blind, Randomized, Controlled Clinical Trial

et al. 2014

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Background: This study was conducted to evaluate the effects of daily consumption of synbiotic bread on the metabolic status of patients with type 2 diabetes mellitus. Methods: This randomized, double-blind, controlled clinical trial was performed in 81 diabetic patients. The subjects were randomly assigned to consumption of synbiotic (n = 27), probiotic (n = 27), or control bread (n = 27) for 8 weeks 3 times a day in a 40-gram package. The synbiotic bread contained Lactobacillus sporogenes (1 × 10⁸ CFU) and 0.07 g inulin per 1 g. The probiotic bread contained L. sporogenes (1 × 10⁸ CFU per 1 g). Fasting blood samples were taken at baseline and after an 8-week intervention for quantification of related factors. Results: Consumption of the synbiotic bread resulted in a significant reduction in serum insulin levels (-3.2 ± 5.4 vs. -0.3 ± 3.4 and 0.6 ± 4.7 µIU/ml, respectively, p = 0.007), homeostatic model assessment for insulin resistance scores (-1.5 ± 2.7 vs. -0.2 ± 1.6 and 0.4 ± 3.5, respectively, p = 0.03), and homeostatic model assessment-β-cell function (-7.2 ± 16.3 vs. -0.7 ± 10.8 and 0.7 ± 8.2, respectively, p = 0.04) compared to the probiotic and control breads. We did not find any significant effect of synbiotic bread consumption on fasting plasma glucose, the quantitative insulin sensitivity check index, or serum hs-CRP levels compared to other breads. Conclusion: Consumption of the synbiotic bread among diabetic patients had beneficial effects on insulin metabolism.

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“…It was found that daily intakes of VDY drink, improved glycemic status of T2DM patients, with or without further calcium content. In another trial conducted on GDM patients, daily consumption of probiotic yoghurt also exhibited beneficial effects on insulin resistance [11] . These previous fruitful trials on both T2DM and GDM have prompted us to investigate the potential effects of VDY drink on GDM women.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, in a recent randomized clinical trial, daily consumption of probiotic yoghurt drink was found to have beneficial ef-fect in maintaining serum insulin levels and might help pregnant women prevent developing insulin resistance [11] . To the best of our knowledge, no report has been conducted to assess the effects of vitamin D-supplemented yogurt (VDY) drink on insulin resistance and lipid profiles of pregnant women diagnosed of GDM.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D<sub>3</sub>-Supplemented Yogurt Drink Improves Insulin Resistance and Lipid Profiles in Women with Gestational Diabetes Mellitus: A Randomized Double Blinded Clinical Trial

Xing²

2016

Ann Nutr Metab

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Background: Our study aimed to examine the effects of daily consumption of vitamin D₃-supplemented yogurt (VDY) drink on insulin resistance and lipid profiles in pregnant gestational diabetes mellitus (GDM) patients. Methods: Participants aged 24-32 years in their second trimester were randomly assigned to consume either plain yogurt or VDY daily for 16 weeks. Metabolic and lipid profiles including levels of fasting plasma glucose (FPG), serum insulin, triacylglycerol (TAG), total cholesterol (TC) and low-density lipoprotein (LDL) were assessed at baseline (week 0) and end of trial (week 16). Results: After 16 weeks of intervention, insulin-related variables including FPG and serum insulin levels were markedly lower in VDY group participants. Insulin resistance parameters, such as homeostasis model of assessment of insulin resistance and β cell function, were also significantly reduced in VDY group participants. Moreover, levels of TAG, TC and LDL, as well as the TC to high-density lipoprotein ratio, had also significantly decreased in the VDY group. Conclusion: Daily consumption of VDY drink improves insulin resistance and lipid profiles in women with GDM.

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Effect of daily consumption of probiotic yoghurt on insulin resistance in pregnant women: a randomized controlled trial

Abstract: It is concluded that in contrast to conventional yogurt, daily consumption of probiotic yogurt for 9 weeks maintains serum insulin levels and might help pregnant women prevent developing insulin resistance.

Cited by 145 publications

References 30 publications

The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomised controlled trial

The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomised controlled trial

Effects of Daily Consumption of Synbiotic Bread on Insulin Metabolism and Serum High-Sensitivity C-Reactive Protein among Diabetic Patients: A Double-Blind, Randomized, Controlled Clinical Trial

Vitamin D<sub>3</sub>-Supplemented Yogurt Drink Improves Insulin Resistance and Lipid Profiles in Women with Gestational Diabetes Mellitus: A Randomized Double Blinded Clinical Trial

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