Effect of Daily Treatment with Thai Herb, Kaempferia parviflora, in Hershberger Assay Using Castrated Immature Rats

Trisomboon, Hataitip; Watanabe, Gen; Wetchasit, Phongphat; Taya, Kazuyoshi

doi:10.1262/jrd.18092

Cited by 16 publications

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“…Consistent with the GH effects, KP has a gastroprotective effect and inhibits gastric ulcer formation by increasing gastric mucus and reducing gastric ulcer size in rats [3]. Hence, this reinforces the suggestion that KP increases rat body weight by directly or indirectly acting as testosterone.…”

Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

“…Nowadays, this plant is considered a Thai national herb. Based on studies using gas chromatographic techniques, many kinds of flavonoid substances, including 7,7,3,5,3,5,7,5,7,7, have been found in KP roots [1,2].KP root has been reported to have anti-gastric ulcer activity by preservation of gastric mucous secretion without inhibition of gastric acid secretion in male rats gavaged with an ether extract of KP [3]. In addition, daily administrations of KP at 20, 200, 1,000 or 2,000 mg/kg is not toxic to adult rats; however, 2,000 mg/kg seems to produce an increase in liver weight and decrease in eosinophil numbers (Chewapat et al unpublished data).…”

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confidence: 99%

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Oral Administration of Kaempferia parviflora did not Disturb Male Reproduction in Rats

et al. 2008

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Abstract.To investigate the androgenic effect of Kaempferia parviflora (KP), a Thai herbal plant, adult male rats were randomized into control and KP-treatment groups. Rats were treated orally with water in the control group and with 1,000 mg/kg/day of KP in the treatment group for 45 days. Blood samples were collected on days 10, 20, 30 and 45 for measurement of the serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone, progesterone and corticosterone levels. The reproductive and non-reproductive organs were dissected on day 45 and weighed. Mating behavior was also observed on days 20 and 30. Body weight was measured throughout the study period. The results showed that KP induced an increase in body weight compared with the controls. There were no significant differences in the weights of either reproductive (testis, seminal vesicle plus coagulating gland, levator ani muscle plus bulbocarvernosus muscle and glans penis, except the prostate gland) or non-reproductive organs (kidney, adrenal gland and gastracnemius muscle). There were no significant differences in serum levels of either FSH or LH between the two groups. The serum testosterone and progesterone levels were insignificantly lower in the KP group during the first 30 days. The serum corticosterone levels in the KP group were lower than those in the controls throughout the study period and were significantly low on days 20 and 30. There were no significant changes in mating behavior in the rats treated with KP. Although KP affected the body weight and serum corticosterone level, it did not affect mating behavior, reproductive and non-reproductive organ weights or hormones related to the reproductive system in the adult male rats. Therefore, we conclude that the testosterone-like effect of KP did not disturb the hypothalamicpituitary-testicular axis or male reproduction. Key words: Body weight, Kaempferia parviflora, Luteinizing hormone (LH), Mating behavior, Testosterone (J. Reprod. Dev. 54: [375][376][377][378][379][380] 2008) aempferia parviflora Wall. Ex. Baker (KP), commonly referred to in Thai as Krachai Dum, is an indigenous herb that belongs to the Family Zingiberaceae. Nowadays, this plant is considered a Thai national herb. Based on studies using gas chromatographic techniques, many kinds of flavonoid substances, including 7,7,3,5,3,5,7,5,7,7, have been found in KP roots [1,2].KP root has been reported to have anti-gastric ulcer activity by preservation of gastric mucous secretion without inhibition of gastric acid secretion in male rats gavaged with an ether extract of KP [3]. In addition, daily administrations of KP at 20, 200, 1,000 or 2,000 mg/kg is not toxic to adult rats; however, 2,000 mg/kg seems to produce an increase in liver weight and decrease in eosinophil numbers (Chewapat et al. unpublished data).Native Thai people widely use this plant with alcohol or boiling water in traditional medicine to increase male libido and alleviative impotency because they believe this plant has androgenic activity altho...

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Oral Administration of Kaempferia parviflora did not Disturb Male Reproduction in Rats

et al. 2008

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“…It is possible that aphrodisiac plant enhances sexual behaviors via an increase in the testosterone (Cek et al, 2007a). Trisomboon, Watanabe, Wetchasit, & Taya, (2007) showed that, serum testosterone levels significantly increase in immature rats orally treated with dry Kaempferia parviflora powder (1 g kg -1 ) in water for 5 days. Also, it has been reported that T. terrestris enhance testosterone levels in human and animals (Cek et al, 2007a).…”

Section: Reproductive Performancementioning

confidence: 99%

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Sotoudeh¹,

Movaffagh²

2017

Turk. J. Fish. Aquat. Sci.

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This study evaluated the effects of diet containing 1 and 2 g kg -1 T. terrestris extract on growth and reproductive performance of male Convict cichlid (C. nigrofasciatum). 117 male C. nigrofasciatum with an average initial weight of 2.30 ± 0.04 g were distributed into glass aquariums (13 fish/tank) in 3 replicates. The highest weight gain was obtained in 1 g kg -1 (123.83 ± 6.41 g) followed by 2 g kg -1 extract (121.13 ± 8.09 g) and control (80.10 ± 11.71 g) group (P< 0.05). In groups that received extract, specific growth rate increased significantly (P< 0.05). Comparison of feed conversion ratio and condition factor in different treatments indicates no significant differences (P> 0.05). Protein levels of dried body decreased after feeding the fish with extract (P< 0.05). Fish fed with extract showed higher lipid and moisture content than fish fed by control diet (P< 0.05). The highest belly diameter was observed in treatment containing 1 g kg -1 extract (9.93 ± 0.23 cm, P< 0.05). Fertilization (%) decreased significantly in 2 g kg -1extract when compared with control and other group (P< 0.05). The highest amount of hatching rate (%) was observed in 1 g kg -1(94.24 ± 3.01) and its least amount was found in 2 g kg -1 extract (72.65 ± 0.23, P> 0.05).

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“…8,9) The extract of the rhizomes of K. parviflora and its constituents were revealed to exhibit several pharmacological activities, such as antiplasmoidal, antifungal, 2) antiinflammatory, [10][11][12] α-glucosidase inhibitory, 13) and xanthine oxidase inhibitory 1) activities and cytotoxicity of several tumor cell lines 14,15) as well as effect of P-glycoprotein function 16) and modulation of multi-drug resistance in cancer cells.…”

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Structures of Two New Phenolic Glycosides, Kaempferiaosides A and B, and Hepatoprotective Constituents from the Rhizomes of <i>Kaempferia parviflora</i>

et al. 2012

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Two new phenolic glycosides, kaempferiaosides A and B were isolated from the rhizomes of Kaempferia parviflora (Zingiberaceae) together with 24 known compounds. Their structures including absolute stereochemistry were elucidated on the basis of chemical and spectroscopic evidence. Among the isolates, 5,3′-dihydroxy-3,7,4′-trimethoxyflavone showed higher activity than silybin, a commercial hepatoprotective agent.Key words Kaempferia parviflora; Zingiberaceae; kaempferiaoside; hepatoprotective activity; Krachai Dum A Zingiberaceae plant, Kaempferia parviflora WALL. ex BAKER, is widely distributed in Thailand and is known as Krachai Dum.1,2) The rhizomes of this plant are tinged with-dark purple to black, and have traditionally been used for the treatment of hypertension, [3][4][5] allergy, 6) gastrointestinal disorders, 7) and impotence. 8,9) The extract of the rhizomes of K. parviflora and its constituents were revealed to exhibit several pharmacological activities, such as antiplasmoidal, antifungal, 2) antiinflammatory, [10][11][12] α-glucosidase inhibitory, 13) and xanthine oxidase inhibitory 1) activities and cytotoxicity of several tumor cell lines 14,15) as well as effect of P-glycoprotein function 16) and modulation of multi-drug resistance in cancer cells. 17)Recently, rhizomes of K. parviflora powder was found to show preventive effect from obesity and its downstream symptoms. 18) By a previous chemical study on K. parviflora, presence of several methoxyflavones and related phenolic constituents have been revealed. 2,5,6,[10][11][12][13][14][15]17,[19][20][21][22] During the course of our characterization studies on Thai natural medicines, [23][24][25][26][27][28][29][30][31][32] two new phenolic glycosides named kaempferiaosides A (1) and B (2) were isolated from the rhizomes of K. parviflora together with 24 known compounds. This paper deals with the structure elucidation of 1 and 2, as well as hepatoprotective effect of the constituents from the rhizomes of K. parviflora on D-galactosamine (D-GalN)-induced cytotoxicity in primary cultured mouse hepatocytes.The dried rhizomes of K. parviflora cultivated at Loei province, Thailand were extracted with methanol to give a methanolic extract (7.10% from the dried rhizomes). The methanolic extract was partitioned into an EtOAc-H 2 O (1 : 1, v/v) mixture to furnish an EtOAc-soluble fraction (3.82%) and an aqueous phase. The aqueous phase was subjected to Diaion HP-20 column chromatography (H 2 O → MeOH) to give H 2 O-and MeOH-eluted fractions (2.04, 1.23%, respectively). As shown in Table 1, the EtOAc-soluble fraction and the MeOH-eluted fraction exhibited hepatoprotective activity, but the H 2 Oeluted fraction lacked the activity. The EtOAc-soluble fraction was subjected to normal-and reversed-phase column chromatographies, and finally HPLC to give 5-hydroxy-7-methoxyflavone 33) (3, 0.113%), 5,7-dimethoxyflavone rel-(5aS, 10bS)-5a,10b-dihydro-1,3,5a,9-tetrahydroxy-8-methoxy-6H-benz[b]

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Effect of Daily Treatment with Thai Herb, Kaempferia parviflora, in Hershberger Assay Using Castrated Immature Rats

Cited by 16 publications

References 21 publications

Oral Administration of Kaempferia parviflora did not Disturb Male Reproduction in Rats

Oral Administration of Kaempferia parviflora did not Disturb Male Reproduction in Rats

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Structures of Two New Phenolic Glycosides, Kaempferiaosides A and B, and Hepatoprotective Constituents from the Rhizomes of <i>Kaempferia parviflora</i>

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