Effect of Dayak Onion (<i>Eleutherine bulbosa</i> (Mill.) Urb) on Uterine wall and Lipid Profiles of Ovariectomized Rat

Purnamasari, A. Bida; Bahtiar, Anton

doi:10.3844/ojbsci.2018.1.6

Cited by 3 publications

(4 citation statements)

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“…Biological activities of the bulb extracts have been reported, including inhibit bacterial growth particularly Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa (Jiang et al, 2020). E. bulbosa bulb extracts could increase bone calcium level and bone weight (Bahtiar and Annisa, 2018), decrease the lipid profile of hypoestrogenic of rat, due to binding of eleutherinol to the estrogen receptors (Purnamasari and Bahtiar, 2018). The biological activities of E. bulbosa bulb extracts was correlated to its antioxidant content, including flavonoids and phenols (Preethy et al, 2016;Shi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Biology and bulb production of Eleutherine bulbosa (Iridaceae), a native species from Borneo, Indonesia

2021

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Eleutherine bulbosa is a known ornamental plant of the Iris family, which originated from Central Borneo, Indonesia. The bulbs of E. bulbosa have long been used as a medicinal source by the local people of Borneo. Despite its known medicinal and other values, studies on the morphology and efficiency in bulb production of this species are limited. The aims of our study are to examine the vegetative and reproductive morphology of E. bulbosa, and to determine the effect of various dosages of NPK fertilizer on flowering and bulb production. The plants were grown in pots using potting mix consists of equal volume of burnt rice hulls, cocopeat, and organic manures (1:1:1). Our study showed that E. bulbosa has a cymose rhipidium inflorescence with 25-50 mm long peduncles, have 3-4 umbel on the secondary axis, each consists of 10-12 florets that opens in turn every day. Florets are 20-30 mm long, 20 mm in diameter, 10-15 mm pedicels, and short-lived. The perianth is white, about 25 mm wide with yellow anthers and stigma. Fruits were not formed during the duration of the study. NPK fertilizer application at the lowest dose of 1 g per pot had promoted earlier shoot emergence and vegetative growth, including plant height, leaf number, leaf size, number of tillers, and bulb production compared to control (no fertilizer). Application of fertilizer at 1 and 2 g per plant significantly promoted earlier flowering, whereas application at 3 g per plant delayed and reduced the proportion of flowering plants. The results of this study can aid in taxonomic identification and efficient cultivation of this plant for uses as potted flowering ornamentals or bulb production for different purposes. Higher cultivation and reduced wild harvesting can result in the conservation of this species.

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Section: Introductionmentioning

confidence: 99%

Biology and bulb production of Eleutherine bulbosa (Iridaceae), a native species from Borneo, Indonesia

2021

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“…The content in EEB associated with estrogen receptors is liquiritigenenin and liquiritigenin activity more to the β estrogen receptor, so it does not cause an increase in wet weight 31 . Other studies have shown that EEB does not cause an increase in wet uterus weight 32 . Daidzein which is a phytoestrogen compound in cowpeas will undergo biotransformation to equol.…”

Section: Pharmacokinetic Of Equol Analysismentioning

confidence: 85%

“…The positive control group using raloxifene did not show on the quality of life because it can cause vaginal dryness, pain, itching, and other such changes 35 , 36 . Estrogen therapy is known to be effective for treating vulvovaginal atrophy caused by hypoestrogenic conditions or due to increasing age in menopausal women 32 . The condition of decreasing estrogen levels in the blood causes a negative feedback mechanism that explains the occurrence of overexpression of REα 37 .…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic Profile of Equol in the Combination of 70% Ethanolic Extract Dayak Onion Bulbs (Eleutherine bulbosa (mill.) Urb) and Cowpea (Vigna unguiculata (l.) Walp.) and their Effect on Postmenopause Syndrome

Hersipa

Katrin

Bahtiar

2019

Journal of Natural Remedies

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Alternative therapies for postmenopausal conditions are needed because of the high risks that outweigh the benefits of using hormone replacement therapy. Equol is metabolized from daidzein and is well-known as a supplement for postmenopausal conditions. Lately, liquiritigenin is also known to have a good effect on postmenopausal conditions. The aim of this study was to note the effect of the combination of Eleutherina bulbosa 70% Ethanol Extract (EEB) containing daidzein and Vigna unguiculata (EVU) containing liquiritigenin to obtain a better effect for uterine morphology, vaginal histopathology, and hot flushes. The other aim was to analyze the pharmacokinetic interaction that can affect the level of equol from EVU. Thirty-six female Sprague-Dawley rats were used in this study, 32 rats were ovariectomized (OVX) and 4 rats were Sham. Rats were divided into 9 groups: Sham group (CMC), negative group (CMC), positive group (raloxifene), EVU (100 mg/200g BW), EEB (18 mg/200g BW), The four various doses of combination EEB and EVU (D1-D4) were, EVU dosage was 100 mg/200 g BW and EEB were 36 mg, 18 mg, 9 mg, 4.5 mg/200 g BW respectively. Equol in rat serum was analyzed using HPLC/UV-V is in an isocratic condition. Observation of hot flushes was carried out every week, uterus weight wet and vaginal epithelium at the end of the treatment. The D3 and D4 combination decreased the average tail skin temperature 1.86±0.31°C and 1.83± 0.20°C respectively and the rectal temperature 0.58±0.49°C and 0.71±0.28°C (P<0.05). All groups except Sham did not increase the weight of the uterus. The D3 group increased vaginal epithelial thickness to 38.24 ± 6.47 μm (P<0.05). The combination did not significantly change equol pharmacokinetic parameters. The combination of Eleutherina bulbosa 70% ethanol extract (EEB) and Vigna unguiculata is better than EVU and EEB alone in reduced post-menopause syndrome in hypoestrogen rats without changing equol pharmacokinetic parameters.

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“…Similarly, in another study conducted by Bahtiar and Annisa [90], the bulb of E. bulbosa significantly increased the calcium level, weight, and bone length in hypoestrogenic rats compared to the tamoxifen-induced group. Other studies also indicated that the E.bulbosa bulb could reduce lipids in ovariectomized rats [91].…”

Section: Effect On the Reproductive System Disordersmentioning

confidence: 94%

Eleutherine bulbosa (Mill.) Urb. Bulb: Review of the Pharmacological Activities and Its Prospects for Application

Kamarudin

Sayuti

Razak

et al. 2021

IJMS

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Natural product is an excellent candidate for alternative medicine for disease management. The bulb of E. bulbosa is one of the notable Iridaceae family with a variety therapeutic potential that is widely cultivated in Southeast Asia. The bulb has been used traditionally among the Dayak community as a folk medicine to treat several diseases like diabetes, breast cancer, nasal congestion, and fertility problems. The bulb is exceptionally rich in phytochemicals like phenolic and flavonoid derivatives, naphthalene, anthraquinone, and naphthoquinone. The electronic database was searched using various keywords, i.e., E. bulbosa, E. americana, E. palmifolia, E. platifolia, and others due to the interchangeably used scientific names of different countries. Scientific investigations revealed that various pharmacological activities were recorded from the bulb of E. bulbosa including anti-cancer, anti-diabetic, anti-bacterial, anti-fungi, anti-viral, anti-inflammatory, dermatological problems, anti-oxidant, and anti-fertility. The potential application of the bulb in the food industry and in animal nutrition was also discussed to demonstrate its great versatility. This is a compact study and is the first study to review the extensive pharmacological activities of the E. bulbosa bulb and its potential applications. The development of innovative food and pharma products from the bulb of E. bulbosa is of great interest.

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Effect of Dayak Onion (Eleutherine bulbosa (Mill.) Urb) on Uterine wall and Lipid Profiles of Ovariectomized Rat

Cited by 3 publications

References 15 publications

Biology and bulb production of Eleutherine bulbosa (Iridaceae), a native species from Borneo, Indonesia

Biology and bulb production of Eleutherine bulbosa (Iridaceae), a native species from Borneo, Indonesia

Pharmacokinetic Profile of Equol in the Combination of 70% Ethanolic Extract Dayak Onion Bulbs (Eleutherine bulbosa (mill.) Urb) and Cowpea (Vigna unguiculata (l.) Walp.) and their Effect on Postmenopause Syndrome

Eleutherine bulbosa (Mill.) Urb. Bulb: Review of the Pharmacological Activities and Its Prospects for Application

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