Effect of deep vein thrombosis on ischaemia-modified albumin levels

Menteşe, Ahmet; Menteşe, Ümit; Türedi, Süleyman; Gunduz, Abdülkadir; Karahan, Süleyman Caner; Topbaş, Murat; Turan, Ayşe Zengin; Patan, Tevfik; Turkmen, Süha; Okur, Gökcan; Eminagaoglu, M.

doi:10.1136/emj.2007.056614

Cited by 30 publications

(23 citation statements)

References 19 publications

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“…IMA levels have also been studied in the context of pulmonary embolism and peripheral arterial disease. [3][4][5] Two recent reports found IMA to be valuable in the early diagnosis of intestinal ischemia. The first, a casecontrol study, found serum IMA levels (measured using the same rapid colorimetric, albumin-cobalt binding test as we used in our study) to be significantly higher (0.26 ± 0.06 ABSU) in patients with mesenteric ischemia than in those of the control group (0.16 ± 0.02 ABSU).…”

Section: Discussionmentioning

confidence: 99%

“…Ischemia-modified albumin (IMA) is a relatively recently described marker that measures cobalt binding to albumin and has been suggested as a valuable tool in the early diagnosis of a variety of ischemic conditions, such as acute myocardial ischemia, pulmonary embolism, and peripheral arterial disease. [3][4][5] Doppler ultrasonography, spiral computed tomography, and mesenteric angiography are commonly used imaging modalities for diagnosing mesenteric ischemia. [6][7][8] These can be invasive, costly, viewer-dependent, and time-consuming.…”

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confidence: 99%

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The Diagnostic Value of Ischemia-modified Albumin in a Rat Model of Acute Mesenteric Ischemia

Uygun

Yılmaz

Pekdemir

et al. 2011

Academic Emergency Medicine

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Objectives: Previous studies have demonstrated that ischemia-modified albumin (IMA) is a useful marker for the diagnosis of ischemic events. This study aimed to determine the value of ischemia-modified plasma albumin in the early diagnosis of acute mesenteric ischemia in an experimental model. Methods:The study was performed on 32 Wistar albino rats divided into control (n = 8), sham (n = 8), 2-hour (n = 8), and 6-hour (n = 8) ischemia groups. Mesenteric ischemia was created by arterial occlusion, and then blood samples (2 mL) were collected and centrifuged. Serum levels of IMA were measured by a rapid calorimetric test that determined the reduced cobalt binding to albumin. For histopathologic evaluation, samples of the small intestine were obtained from the animals after they were euthanized at the end of the experiment.Results: Histopathologic damage of the intestinal wall correlated with the duration of ischemia. While the mean pathology scores of the 2-and 6-hour ischemia groups were different from each other, IMA levels (mean ± SD) in the four groups were not significantly different from each other: 0.55 ± 0.07 absorbance units (ABSU) in the control group, 0.62 ± 0.09 ABSU in the sham group, 0.60 ± 0.07 ABSU in the 2-hour ischemia group, and 0.64 ± 0.12 ABSU in the 6-hour ischemia group (p = 0.153). Conclusions:Serum IMA values were not useful in the early diagnosis of acute mesenteric ischemia. Further studies to investigate ischemic and nonischemic conditions that affect IMA levels are needed.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The Diagnostic Value of Ischemia-modified Albumin in a Rat Model of Acute Mesenteric Ischemia

Uygun

Yılmaz

Pekdemir

et al. 2011

Academic Emergency Medicine

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“…IMA, which appears to be an indicator of oxidative stress, may not be specific for cardiac ischemia. Studies have demonstrated that many conditions may elevate IMA levels, such as mesenteric ischemia, peripheral arterial occlusion, deep venous thrombosis, stroke and acute cardiac arrest, and that IMA may be a diagnostic biomarker for these conditions (21)(22)(23)(24)(25). There are only a few reports in the literature about the diagnostic value of IMA in the diagnosis of PE.…”

Section: Discussionmentioning

confidence: 99%

Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism

Türedi¹,

Karahan²,

Menteşe³

et al. 2010

Anadolu Kardiyol Derg

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ÖZETAmaç: İki farklı radyolojik parametre, pulmoner arter obstrüksiyon indeksi (PAOI) ve sağ ventrikül/sol ventrikül oranı (RV/LV) temel alınarak, radyolojik görüntüleme-esaslı pulmoner embolizm şiddet skoru ile D-dimer ve iskemi modifiye albümin (IMA) düzeyleri arasındaki muhtemel ilişkiyi incelemek. Yöntemler: Bu prospektif kohort çalışmasında, acil servise başvuran ve spiral bilgisayarlı tomografi (CT) ile PE kesin tanısı konulan kırk yedi hasta çalış-maya dahil edildi. D-dimer ve IMA düzeyleri sırasıyla immuno-turbidimetrik ve kolorimetrik metodlarla belirlendi. Bilgisayarlı tomografi görüntülerinden PAOI ve RV/LV oranları hesaplandı. Biyokimyasal parametrelerin gruplar arasındaki seviyeleri Mann-Whitney U test ve Kruskal-Wallis test kullanılarak karşılaştırıldı ve radyolojik skorlar ile ilişkileri Spearman korelasyon testi kullanılarak belirlendi. Bulgular: Hesaplanan PAOI ve RV/LV oranlarının analizi aralarında belirgin bir ilişki olduğunu yansıttı (r=0.036, p=0.023). PAOI temelinde oluşturulan hafif (< %40), orta (%40 -%60) ve şiddetli (> %60) PE grupları arasında D-dimer düzeyleri göze çarpan oranda farklıydı (p=0.039). Bu fark hafif grup, PAOI< %40, ile şiddetli grup, PAOI> %60 arasındaki D-dimer seviyelerindeki farklılıktan kaynaklanıyordu (p=0.02; Z= -2.328). Aynı zamanda, D-dimer düzeyleri ile PAOI pozitif bir korelasyon gösteriyordu, fakat D-dimer düzeyleri ile RV/LV oranı arasında benzer bir korelasyon yoktu. İskemi modifiye albümin düzeyleri ile D-dimer düzeyleri, PAOI ve RV/LV oranı arasında anlamlı bir korelasyon yoktu. Sonuç: Radyolojik parametreler temelinde PE'nin şiddetinin biyokimyasal olarak belirlenmesinde D-dimer, yeni bir marker olarak önerilen IMA'ya göre daha uygun bir marker olabilir. (Anadolu Kardiyol Derg 2010; 10: 346-52) Anah tar ke li me ler: D-dimer, iskemi modifiye albümin, pulmoner embolizm, pulmoner arter obstrüksiyon indeksi, radyolojik ciddiyet, spiral bilgisayarlı tomografi ABS TRACTObjective: To investigate possible relationship between the D-dimer and ischemia-modified albumin (IMA) levels and radiological imagingbased severity scores in pulmonary embolism (PE) based on two different radiological characteristics; the pulmonary arterial obstruction index (PAOI) and the right ventricle/left ventricle (RV/LV) ratio. Methods: In this prospective cohort study, forty-seven patients presenting to the emergency department and definitively diagnosed with PE using spiral computerized tomography (CT) were initially enrolled in the study. Levels of IMA and D-dimer were assessed colorimetrical and immuno-turbidimetric methods, respectively. The PAOI and RV/LV ratios were calculated from CT images. The levels of biochemical parameters between the groups were compared with use of Mann-Whitney U and Kruskal-Wallis tests and relationship between the radiological scores were assessed using the Spearman correlation test. Results: Analysis of the calculated PAOI and RV/LV ratio revealed a significant correlation between them (r=0.36, p=0.023). D-dimer levels differed considerably among the...

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“…DVT is believed to be a multifactorial disease that occurs (IMA) levels in a DVT group compared with a control group [23]. IMA, a Food and Drug Administration-approved serum biomarker of cardiac ischemia, appears to be an indicator of oxidative stress and may not be specific for cardiac ischemia [24].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of oxidative stress balance in acute deep vein thrombosis

et al. 2015

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Objective: The purpose of this study was to show the association between oxidative stress and deep venous thrombosis (DVT) by determining total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) values in patients with DVT and to take precautionary measures to balance oxidative status. Methods: TOS, TAS and OSI levels in serum from 52 individuals with DVT and 45 without DVT were compared. Results: TOS and OSI levels were significantly higher in patients with DVT compared with the control group (p<0.0001), but no difference was observed in TAS levels (p=0.118). The patient group was divided into two subgroups, idiopathic and secondary DVT. TOS and OSI levels were significantly higher patients with both idiopathic DVT and secondary DVT compared to the control group (p<0.0001). TAS levels were significantly higher in patients with idiopathic DVT than in the control group, but no difference was observed in the patients with secondary DVT. Conclusion: Specificity and sensitivity values obtained from the receiver operating characteristic (ROC) curve show that TOS and OSI are both markers that can be used in the diagnosis of DVT. Also, determination of oxidative stress markers may guide clinicians to take necessary precautions to balance oxidative stress in the patients. Key Words: Deep vein thrombosis, oxidative stress, total oxidant status, total antioxidant status Conflict of Interest: The authors have no conflict of interest. ÖZETAmaç: Bu çalışmanın amacı akut derin ven trombozlu (DVT) hastalarda toplam oksidan durum (TOS), toplam antioksidan durum (TAS) ve oksidatif stres indeksi (OSI) düzeylerini ölçerek oksidatif stres ve DVT arasındaki ilişkiyi ortaya koymak ve klinisyenlerin bu hastalarda oksidatif stresi dengelemek üzere koruyucu önlemler almasına yardımcı olmaktır. Metod: Bu çalışmada 52 DVT'li ve 45 DVT olmayan bireylerden alınan serum örneklerinde TOS, TAS ve OSI seviyeleri belirlenerek karşılaştırıldı. Bulgular: TOS ve OSI seviyeleri DVT hastalarında kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı yüksek bulunurken (p<0.0001) TAS seviyelerinde fark görülmedi, p=0.118. Hasta grubu idiopatik ve sekonder DVT olarak iki gruba ayrıldı. TOS ve OSI seviyeleri hem idiyopatik DVT hem de sekonder DVT hastalarında kontrol grubu ile karşılaştırıldı-ğında istatistiksel olarak anlamlı yüksek bulundu (p<0.0001). İdiyopatik DVT hastalarında TAS seviyeleri kontrol grubundan anlamlı yüksek iken sekonder DVT hastalarında fark gözlenmedi. Sonuç: Sonuç olarak ROC eğrisine göre elde edilen spesifite ve sensitivite değerleri TOS ve OSI parametrelerinin DVT'nin tanısında kullanılabilecek birer belirteç olabileceğini göster-mektedir. Aynı zamanda oksidatif stres belirteçlerinin belirlenmesi hastalarda oksidatif stresin düzeltilmesi için klinisyenlere gerekli önlemleri alabilmeleri için yol gösterici olabilir. Anahtar Kelimeler: Derin ven trombozu, oksidatif stres, toplam antioksidan durum, toplam oksidan durum Çıkar Çatışması: Yazarların çıkar çatışması yoktur.

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Effect of deep vein thrombosis on ischaemia-modified albumin levels

Abstract: DVT is associated with raised serum IMA levels but IMA levels are not suitable as a diagnostic marker for DVT.

Cited by 30 publications

References 19 publications

The Diagnostic Value of Ischemia-modified Albumin in a Rat Model of Acute Mesenteric Ischemia

The Diagnostic Value of Ischemia-modified Albumin in a Rat Model of Acute Mesenteric Ischemia

Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism

Evaluation of oxidative stress balance in acute deep vein thrombosis

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