Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo

Matoušková, Petra; Bártíková, Hana; Boušová, Iva; Szotáková, Barbora; Martin, Jan; Skorkovská, Jana; Hanušová, Veronika; Tománková, Veronika; Anzenbacherová, Eva; Lišková, Barbora; Anzenbacher, Pavel; Skálová, Lenka

doi:10.1016/j.jff.2014.06.026

Cited by 10 publications

(9 citation statements)

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“…The pharmacological effects and safety of this plant have been confirmed, particularly in respect of catechins, which make up 30% of the dry weight of tea leaves ( 13 ). Water extracts from green tea contain abundant bioactive constituents and have shown various biological activities, including antioxidant ( 14 ), anti-obesity ( 15 ), hypolipidemic, antidiabetic ( 16 ), anti-inflammatory, and anticancer ( 17 ) properties. Tea drinking is closely associated with bone health and may provide protection against osteoporosis and osteoporotic fracture; these effects have been verified both in vitro and in vivo ( 13 , 18 – 20 ).…”

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confidence: 99%

Green tea (Camellia sinensis) aqueous extract alleviates postmenopausal osteoporosis in ovariectomized rats and prevents RANKL-induced osteoclastogenesis in vitro

Wu¹,

Xie²,

Zhu³

et al. 2018

Food & Nutrition Research

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BackgroundGreen tea (Camelliasinensis [L.] Kuntze) belongs to the plant family Theaceae and is mainly distributed in East Asia, the Indian subcontinent and Southeast Asia. This plant has been proven to be beneficial to human health, and green tea is the second most consumed beverage in the world after water. However, until now, the effect of green tea aqueous extract (GTE) upon postmenopausal osteoporosis has remained unclear. In this study, we investigated the therapeutic effects of GTE on estrogen deficiency-induced osteoporosis and explored the possible mechanisms in vivo and in vitro.Materials and methodsOvariectomized (OVX) female rats were orally administered with GTE at doses of 60, 120, and 370 mg kg−1 for 13 consecutive weeks. The biochemical parameters, bone gla protein, alkaline phosphatase, acid phosphatase, estrogen, interleukin-1β, and interleukin-6 in blood samples were detected, and histological change in bones was analyzed by hematoxylin and eosin staining. Meanwhile, the mechanisms of GTE on osteoclast formation were explored in RAW 264.7 cells induced by receptor activation of the nuclear factor kappa B ligand (RANKL).ResultsThe results showed that GTE could increase bone mass and inhibit trabecular bone loss in OVX rats. Furthermore, real-time quantitative reverse transcription polymerase chain reaction analysis from in vitro experiments also showed that GTE reduced the mRNA expression of osteoclast-associated genes such as cathepsin K (cath-K), c-Fos, matrix metalloproteinase 9, nuclear factor of activated T cells cytoplasmic 1 (NFATc1) and tartrate-resistant acid phosphatase. In addition, GTE caused a reduction in the protein levels of NFATc1, c-Fos, c-src and cath-K.ConclusionEvidence from both animal models and in vitro experiments suggested that GTE might effectively ameliorate the symptoms of osteoporosis in OVX rats and inhibit RANKL-induced osteoclast-specific gene and protein expression.

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confidence: 99%

Green tea (Camellia sinensis) aqueous extract alleviates postmenopausal osteoporosis in ovariectomized rats and prevents RANKL-induced osteoclastogenesis in vitro

Wu¹,

Xie²,

Zhu³

et al. 2018

Food & Nutrition Research

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“…Mice were fed a standard diet enriched with Polyphenon 60 (GTE), a purifi ed form of a green tea extract with the following composition: 327 mg of (-)-epigallocatechin, 125 mg of (-)-epicatechin, 418 mg of EGCG, 130 mg of (-)-epicatechin gallate, and traces of (-)-gallocatechin and (-)-gallocatechin-3-gallate per 1 g of GTE [Matouskova et al, 2014]. It is necessary to state that all experiments with lean and MSG obese mice receiving the GTE-enriched diet were performed at the same time with the same mice litters, which enables direct comparison of the obtained results, part of which has been recently published [Matouskova et al, 2014;Bartikova et al, 2015;Tomankova et al, 2015].…”

Section: Resultsmentioning

confidence: 99%

“…It is necessary to state that all experiments with lean and MSG obese mice receiving the GTE-enriched diet were performed at the same time with the same mice litters, which enables direct comparison of the obtained results, part of which has been recently published [Matouskova et al, 2014;Bartikova et al, 2015;Tomankova et al, 2015].…”

Section: Resultsmentioning

confidence: 99%

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

Bártíková¹,

Boušová²,

Matoušková³

et al. 2017

Pol. J. Food Nutr. Sci.

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Key words: monosodium glutamate-induced obesity, catechins, oxidative stress, polyphenon 60Green tea and green tea extracts (GTE) are often incorporated into diet intended to weight reduction, although the information about their effi cacy in obese individuals is insuffi cient. The present study was designed to follow up the effect of defi ned and standardized GTE in mice with obesity induced by monosodium L-glutamate. Obese mice were fed with GTE-supplemented diet in three dosage regimens: 28-day and 3-day intake of 1 g GTE in 1 kg of diet and 28-day intake of 0.1 g GTE in 1 kg of diet. The information on body weight, food intake, oxidation stress parameters in blood and antioxidant enzymes activity in liver and small intestine was obtained. High doses of GTE decreased the specifi c activities of glutathione reductase and catalase and increased concentrations of malondialdehyde in blood. Specifi c activities of antioxidant enzymes in the liver and small intestine were not altered after GTE treatment except the decrease of NAD(P)H:quinone oxidoreductase activity. Our results showed that GTE did not affect average body weight and did not markedly improve antioxidant status in glutamate-induced obese mice. Moreover, intake of high doses of GTE made antioxidant defense in obese animals even worse.Unauthenticated Download Date | 5/12/18 3:35 AM

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“…A number of studies in recent years have highlighted the potential risk inherent in the uncontrolled use of herbal medicines concurrent with conventional therapeutic regimens and emphasized the need for regulation in this field based on a set of evaluation criteria [ 207 – 211 ]. We propose here that it is the polyphenols in the herbal preparations that interact with CYP3A4, modify the metabolism of xenobiotics and drugs, and consequently change the active doses of prescribed medicines and the nature of the prescribed compounds.…”

Section: Discussionmentioning

confidence: 99%

Interactions between CYP3A4 and Dietary Polyphenols

Basheer

Kerem

2015

Oxidative Medicine and Cellular Longevity

139

124

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The human cytochrome P450 enzymes (P450s) catalyze oxidative reactions of a broad spectrum of substrates and play a critical role in the metabolism of xenobiotics, such as drugs and dietary compounds. CYP3A4 is known to be the main enzyme involved in the metabolism of drugs and most other xenobiotics. Dietary compounds, of which polyphenolics are the most studied, have been shown to interact with CYP3A4 and alter its expression and activity. Traditionally, the liver was considered the prime site of CYP3A-mediated first-pass metabolic extraction, but in vitro and in vivo studies now suggest that the small intestine can be of equal or even greater importance for the metabolism of polyphenolics and drugs. Recent studies have pointed to the role of gut microbiota in the metabolic fate of polyphenolics in human, suggesting their involvement in the complex interactions between dietary polyphenols and CYP3A4. Last but not least, all the above suggests that coadministration of drugs and foods that are rich in polyphenols is expected to stimulate undesirable clinical consequences. This review focuses on interactions between dietary polyphenols and CYP3A4 as they relate to structural considerations, food-drug interactions, and potential negative consequences of interactions between CYP3A4 and polyphenols.

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Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo

Cited by 10 publications

References 36 publications

Green tea (Camellia sinensis) aqueous extract alleviates postmenopausal osteoporosis in ovariectomized rats and prevents RANKL-induced osteoclastogenesis in vitro

Green tea (Camellia sinensis) aqueous extract alleviates postmenopausal osteoporosis in ovariectomized rats and prevents RANKL-induced osteoclastogenesis in vitro

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

Interactions between CYP3A4 and Dietary Polyphenols

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