Effect of dehydroepiandrosterone on atherosclerosis in postmenopausal women

Zhang, Siwei; Zhou, Jing; Li, Lijuan; Pan, Xinyao; Lin, Jing; Li, Chuyu; Leung, Wing Ting; Wang, Ling

doi:10.5582/bst.2021.01320

Cited by 6 publications

(4 citation statements)

References 119 publications

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“…After menopause, females’ ovarian function decreases, dyslipidemia increases ( Peters et al, 1999 ), vascular smooth muscle cells migrate or proliferate, and oxidative stress and inflammatory reactions aggravate. Generally speaking, the prevalence of atherosclerosis increases in postmenopausal females, and the stiffness of the female vasculature increases ( Zhang et al, 2022 ). Findings also suggest that the effects of estrogen may be concentrated in the proximal aortic region ( Waddell et al, 2001 ).…”

Section: Discussionmentioning

confidence: 99%

A study on the ultimate mechanical properties of middle-aged and elderly human aorta based on uniaxial tensile test

Chen,

Zhao,

et al. 2024

Front. Bioeng. Biotechnol.

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Background:The mechanical properties of the aorta are particularly important in clinical medicine and forensic science, serving as basic data for further exploration of aortic disease or injury mechanisms.Objective:To study the influence of various factors (age, gender, test direction, anatomical location, and pathological characteristics) on the mechanical properties and thickness of the aorta.Methods:In this study, a total of 24 aortas (age range: 54–88 years old) were collected, one hundred and seventy-four dog-bone-shaped samples were made, and then the uniaxial tensile test was run, finally, pathological grouping was performed through histological staining.Results:Atherosclerotic plaques were mainly distributed near the openings of blood vessel branches. The distribution was most severe in the abdominal aorta, followed by the aortic arch. Aortic atherosclerosis was a more severe trend in the male group. In the comparison of thickness, there were no significant differences in age (over 50 years) and test direction, the average thickness of the aorta was greater in the male group than the female group and decreased progressively from the ascending aorta to the abdominal aorta. Comparing the mechanical parameters, various parameters are mainly negatively correlated with age, especially in the circumferential ascending aorta (εp “Y = −0.01402*X + 1.762, R2 = 0.6882”, εt “Y = −0.01062*X + 1.250, R2 = 0.6772”); the parameters of males in the healthy group were larger, while the parameters of females were larger in atherosclerosis group; the aorta has anisotropy, the parameters in the circumferential direction were greater than those in the axial direction; the parameters of the ascending aorta were the largest in the circumferential direction, the ultimate stress [σp “1.69 (1.08,2.32)”] and ultimate elastic modulus [E2“8.28 (6.67,10.25)”] of the abdominal aorta were significantly larger in the axial direction; In the circumferential direction, the stress [σp “2.2 (1.31,3.98)”, σt “0.13 (0.09,0.31)”] and ultimate elastic modulus (E2 “14.10 ± 7.21”) of adaptive intimal thickening were greater than those of other groups, the strain (εp “0.82 ± 0.17”, εt “0.53 ± 0.14”) of pathological intimal thickening was the largest in the pathological group.Conclusion:The present study systematically analyzed the influence of age, sex, test direction, anatomical site, and pathological characteristics on the biomechanical properties of the aorta, described the distribution of aortic atherosclerosis, and illustrated the characteristics of aortic thickness changes. At the same time, new insights into the grouping of pathological features were presented.

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Section: Discussionmentioning

confidence: 99%

A study on the ultimate mechanical properties of middle-aged and elderly human aorta based on uniaxial tensile test

Chen,

Zhao,

et al. 2024

Front. Bioeng. Biotechnol.

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“…Therefore, dehydroepiandrosterone conversion reaction is possible, the key point is the conversion of E1 to dehydroepiandrosterone. Dehydroepiandrosterone can be converted to estrogen in humans and animals [23,25,39]. The conversion of E1 to dehydroepiandrosterone has not been reported, so this step needs to be validated to refine route.…”

Section: Discussionmentioning

confidence: 99%

“…Identification of and information about transformation products by bacterial degradation of E2[15][16][17][18][19][20][21][22][23][24][25].…”

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confidence: 99%

Lysinibacillus sp. GG242 from Cattle Slurries Degrades 17β-Estradiol and Possible 2 Transformation Routes

Hao

Gou

et al. 2022

Microorganisms

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Environmental estrogen pollution has long been a concern due to adverse effects on organisms and ecosystems. Biodegradation is a vital way to remove estrogen, a strain of Lysinibacillus sp. was isolated, numbered strain GG242. The degradation rate of 100 mg·L−1 17β-estradiol (E2)) > 95% in one week, and compared with extracellular enzymes, intracellular enzymes have stronger degradation ability. Strain GG242 can maintain a stable E2 degradation ability under different conditions (20–35 °C, pH 5–11, salinity 0–40 g·L−1). Under appropriate conditions (30 °C, pH 8, 1 g·L−1 NaCl), the degradation rate increased by 32.32% in one week. Based on the analysis of transformation products, inferred E2 was converted via two distinct routes. Together, this research indicates the degradation potential of strain GG242 and provides new insights into the biotransformation of E2.

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“…The most exclusive function of DHEA is that it can be metabolized to potent androgens and oestrogens (31). Supplementation with DHEA appears to produce more precise results and cause fewer adverse side effects than supplementation with testosterone (32,33). DHEA converts intracellularly to androgens with no significant active testosterone released into the blood (33,34).…”

Section: Mechanism Of Dhea For Dormentioning

confidence: 99%

Advances in understanding the effect and mechanism of dehydroepiandrosterone on diminished ovarian reserve

Wang

Pan

Zhou

et al. 2023

DD&T

Self Cite

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dehydroepiandrosterone, diminished ovarian reserve, testosterone, in vitro fertilization and embryo transfer Diminished ovarian reserve (DOR) refers to the decline in fertility caused by the loss of normal ovarian function. DOR is associated with adverse reactions to ovarian stimulation during in vitro fertilization and embryo transfer (IVF-ET), increasing cycle cancellation rates and reducing pregnancy rates. Although it is well known that dehydroepiandrosterone (DHEA) can be used as a dietary supplement for age-related diseases, its potential has gradually been shown for many diseases. In this review, we focus on the effects of DHEA on DOR, briefly analysing its clinical benefits and limitations and describing the mechanism of function and the clinical trials conducted. Therefore, we summarize the mechanisms and indications of DHEA for DOR.

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Effect of dehydroepiandrosterone on atherosclerosis in postmenopausal women

Cited by 6 publications

References 119 publications

A study on the ultimate mechanical properties of middle-aged and elderly human aorta based on uniaxial tensile test

A study on the ultimate mechanical properties of middle-aged and elderly human aorta based on uniaxial tensile test

Lysinibacillus sp. GG242 from Cattle Slurries Degrades 17β-Estradiol and Possible 2 Transformation Routes

Advances in understanding the effect and mechanism of dehydroepiandrosterone on diminished ovarian reserve

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