In order to study the feasibility of a nano-thermal rod applied to deicing of tunnel pavement in cold region, the performance of the nano-thermal rod was investigated through experiments and numerical simulation methods. First, the heating efficiency of the nano-thermal rod and the carbon fiber heating wire under low voltage conditions were compared. Then, the tunnel pavement model was prepared and experimentally studied in the environmental simulation box. The effects of the arrangement parameters (including arrangement spacing, embedding depth, and input power) and environmental factors (including ambient temperature and immersion state) on the heating rate and heating effect were studied. Finally, COMSOL Multiphysics was employed to verify the experimental results. The experimental results indicate that the working temperature of the nano-thermal rod is approximately 60°C at a low voltage of 3.9V, with a higher heating efficiency compared to the carbon fiber heating wire. Additionally, both the layout form and ambient temperature of the nano-thermal rod significantly impact tunnel pavement temperature and heating rate. Among these factors, input power and ambient temperature have the most pronounced effects. Furthermore, surface moisture adversely affects the deicing. The experimental results were verified by numerical simulation, demonstrating that the error is within 1.48°C. It is concluded that the use of nano-thermal rod for deicing on tunnel pavements in cold areas is feasible.