Effect of Delta-Sleep-Inducing Peptide on Activity of Enzymes of Biogenic Amine Metabolism in the Brain of Wistar and August Rats

Доведова, Е. Л.; Khrustalev, D. A.; Khudoerkov, R. M.

doi:10.1007/s10517-006-0011-9

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…An intraperitoneal injection of DSIP in emotionally reactive male August rats and Wistar rats at a dose of 60 µg/kg led to a significant increase in the activity of monoamine oxidase A after 30 min in the cerebral cortex by 47% and 28%, respectively, and by 62% in both cases in the striatum, indicating activation of the serotoninergic system and inhibition of the dopaminergic system [19].…”

Section: Discussionmentioning

confidence: 94%

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

et al. 2021

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A structural analogue of the DSIP, peptide KND, previously showed higher detoxification efficacy upon administration of the cytotoxic drug cisplatin, compared to DSIP. DSIP and KND were investigated using the model of acute myocardial infarction in male SD rats and the model of acute focal stroke in C57Bl/6 mice. A significant decrease in the myocardial infarction area was registered in KND-treated animals relative to saline-treated control animals (19.1 ± 7.3% versus 42.1 ± 9.2%). The brain infarction volume was significantly lower in animals intranasally treated with KND compared to the control saline-treated animals (7.4 ± 3.5% versus 12.2 ± 5.6%). Injection of KND in the first minute of reperfusion in the models of myocardial infarction and cerebral stroke reduced infarction of these organs, indicating a pronounced cardioprotective and neuroprotective effect of KND and potentiality for the treatment of ischemia-reperfusion injuries after transient ischemic attacks on the heart and brain, when administered during the reperfusion period. A preliminary pilot study using the model of myocardial infarction with the administration of DSIP during occlusion, and the model of cerebral stroke with the administration of KND during occlusion, resulted in 100% mortality in animals. Thus, in the case of ischemia-reperfusion injuries of the myocardium and the brain, use of these peptides is only possible during reperfusion.

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Section: Discussionmentioning

confidence: 94%

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

et al. 2021

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“…3, (Besedovsky et al, 2017)) emphasizes the mutual relation between sleep and endocrine regulation. To what extend this approach translates to an effective modulation of dopamine remains an open question and is so far only implied by prior work exposing rats to a deltasleep-inducing-peptide which lead to an inhibition of the dopaminergic system (Dovedova et al, 2005).…”

Section: Outlook: How To Intervene On Circadian Disruptions In Psycho...mentioning

confidence: 99%

Circadian Rhythms in Auditory Hallucinations and Psychosis

Ngo¹,

Andreou²,

Obleser³

2022

Preprint

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The near-24 hour patterns called circadian rhythms are imprinted in all organisms and influence virtually all aspects of human physiology and behaviour. This recognition of a functioning circadian clockwork permeating essentially all healthy functioning of body and mind quickly leads to the realisation that, in turn, human ailments should be probed for the degree to which they are rooted in or are at least marked by disruptions and dysregulations of circadian clock functions in the human body. In this review, we will focus on psychosis as a key mental illness and foremost one of its cardinal symptoms: auditory hallucinations. We will discuss recent empirical evidence and conceptual advances probing the potential role of circadian disruption in auditory hallucinations. Moreover, an imbalance in excitation and inhibition within cortical networks, which in turn drive a disinhibition of dopaminergic signalling will be highlighted as central physiological mechanism. Finally, we will be proposing two ways of experimentally intervening on the circadian disturbances that occur in psychotic hallucinators.

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“…Administration of DSIP to experimental animals modulates the level of neurotransmitters [2], hormones and neuropeptides [3], and activities of brain enzymes [1]. These changes are most pronounced under stress conditions.…”

mentioning

confidence: 99%

Effect of Delta-Sleep-Inducing Peptide on Expression of Heat Shock Protein 70 kDa in K562 Cells

2009

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For evaluation of the stress-protective influence of delta-sleep inducing peptide we studied its effects on the system of heat-shock proteins in immune cells using the method of flow cytometry. The peptide affected the expression of heat-shock protein 70 kDa in cultured human myeloleukemia K562 cells. Delta-sleep-inducing peptide reduces accumulation of intracellular heat shock proteins 70 kDa in cells cultured under conditions of high density.

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Effect of Delta-Sleep-Inducing Peptide on Activity of Enzymes of Biogenic Amine Metabolism in the Brain of Wistar and August Rats

Cited by 4 publications

References 5 publications

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

Circadian Rhythms in Auditory Hallucinations and Psychosis

Effect of Delta-Sleep-Inducing Peptide on Expression of Heat Shock Protein 70 kDa in K562 Cells

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