Effect of Denervation of Pyloric Antrum on the Gastric Secretory Response to Food

Hunt, D R; Forrest, A. P. M.

doi:10.1038/icb.1975.55

Cited by 2 publications

(3 citation statements)

References 5 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[108] It was suggested that the effectiveness of aliphatic alcohols correlates directly with their lipid solubility, owing to the hydrophobic interactions between the alkyl chains of alcohols and lipid regions within the membrane. [109] Similar hydrophobic interactions between the acyl chains of uridine, which accumulate in the lipid-like structure of bacterial membranes, have also been documented. [110] This interaction potentially leads to a loss of membrane permeability in bacteria, ultimately resulting in bacterial death.…”

Section: Assessing the Antimicrobial Activity Of Nucleoside Analogsmentioning

confidence: 77%

Nucleoside‐Based Drug Target with General Antimicrobial Screening and Specific Computational Studies against SARS‐CoV‐2 Main Protease

Kawsar,

Hossain,

Saha

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

This review article aims to significantly advance the scientific community's efforts to develop effective nucleoside‐based drugs for treating severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and other emerging infectious diseases. This study concentrates on the main viral protease (Mpro) and explores nucleoside‐based compounds as potential therapeutic agents. This investigation investigated the impact of acylation‐induced modifications on the nucleoside hydroxyl group and subsequent properties. Nucleoside analogs, which are recognized for their diverse biochemical properties, were synthesized and rigorously screened to evaluate their antimicrobial efficacy. In the domain of pharmaceutical research, computational pharmacokinetics has emerged as a critical tool, especially in the pursuit of nucleoside analogs as potential therapeutics. In silico methods aid in predicting pharmacokinetic traits, interactions with crucial enzymes, and the stability of these analogs in biological environments, thereby streamlining drug design and reducing experimental costs. Concurrently, computational studies revealed the intricate interactions between the analogs and the active site of the main protease. The amalgamation of experimental screening and computational insights underscores the emergence of potent nucleoside candidates with inhibitory activity against SARS‐CoV‐2 Mpro. Additionally, this review integrates computational studies that provide valuable insights into the interactions between nucleoside analogs and the main protease of SARS‐CoV‐2.

show abstract

Section: Assessing the Antimicrobial Activity Of Nucleoside Analogsmentioning

confidence: 77%

Nucleoside‐Based Drug Target with General Antimicrobial Screening and Specific Computational Studies against SARS‐CoV‐2 Main Protease

Kawsar,

Hossain,

Saha

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…This powerful technology is frequently used in drug discovery processes to guide the acquisition or synthesis of desirable new compounds and to characterize existing molecules. SAR assays were performed according to the membrane permeation concept of Kim (Kim et al, 2007) and Hunt (Hunt, 1975).…”

Section: Structure-activity Relationshipmentioning

confidence: 99%

“…The hydrophobicity of materials as toxicity or alteration of membrane integrity is an important parameter with respect to bioactivity because it is directly related to membrane permeation (Kim et al 2007). Hunt (Hunt 1975) reported that the potency of aliphatic alcohols is directly related to their lipid solubility through hydrophobic interactions between the alkyl chains of alcohols and lipid regions in the membrane.…”

Section: Sar Studymentioning

confidence: 99%

Chemical Synthesis of Cytosine β-D-Riboside Esters for Pathogenicity, Anticancer and Computational Studies

Kawsar¹,

Ferdous²

2022

J. of Sci. and Tech. Res.

View full text Add to dashboard Cite

The growing importance of nucleoside derivatives as unique potential antimicrobial and therapeutic agents has drawn attention to the synthesis of thymidine derivatives. In the present study, cytidine (i.e., cytosine β-D-riboside) was treated with various acyl halides to produce 5ʹ-O-acyl cytidine derivatives by direct acylation method with an excellent yield. To obtain newer derivatives for antimicrobial assessment studies, the 5ʹ-O-cytidine derivatives were further modified into three series of 2′,3′-di-O-acyl cytidine derivatives (schemes 1 and 2) containing a wide variety of functionalities in a single molecular framework. The chemical structures of the newly synthesized derivatives were elucidated by analyzing their physicochemical, elemental, and spectroscopic data. The antimicrobial tests demonstrated that most of the derivatives exhibited significant antibacterial and antifungal activities in vitro. The derivatives 7, 10, and 11 were the most potent derivatives against Pseudomonas aeruginosa, Salmonella abony, and Staphylococcus strains, with the minimum inhibitory concentration ranging from 0.16 ± 0.01 to 1.25 ± 0.03 mg/mL and minimum bactericidal concentration ranging from 0.32 ± 0.01 to 2.5 ± 0.06 mg/mL. The strongest inhibitory activity was observed against Gram-negative bacteria. Some of the derivatives had a strong antifungal activity. The structure–activity relationship (SAR) and X-ray powder diffraction of these acylated products were also studied. In addition, derivative 6 exhibited good anticancer activity against EAC cells. Quantum chemical studies were performed employing density functional theory with B3LYP/3-21G level. To support this observation, molecular docking studies have been performed against HIV-1 reverse transcriptase (RT) (PDB: 3V4I). Most of the molecules studied out here could bind near the crucial catalytic binding site, Tyr181, Ile94, Ile382, Lys374, Val381, Val90, and Tyr34 of the HIV-1 reverse transcriptase (RT), and the molecules were surrounded by other active site residues like Gln332, Trp406, Asn265, Gly93, His96, Pro95, and Thr165. The absorption, distribution, metabolism, excretion, and toxicity properties predicted the improved pharmacokinetic properties of all derivatives. J. of Sci. and Tech. Res. 3(1): 23-40, 2021

show abstract

Effect of Denervation of Pyloric Antrum on the Gastric Secretory Response to Food

Cited by 2 publications

References 5 publications

Nucleoside‐Based Drug Target with General Antimicrobial Screening and Specific Computational Studies against SARS‐CoV‐2 Main Protease

Nucleoside‐Based Drug Target with General Antimicrobial Screening and Specific Computational Studies against SARS‐CoV‐2 Main Protease

Chemical Synthesis of Cytosine β-D-Riboside Esters for Pathogenicity, Anticancer and Computational Studies

Contact Info

Product

Resources

About