PurposeTo compare the impact of three different chemical denture cleansers (CDCs) (Corega, chlorhexidine, and hydrogen peroxide) on the surface roughness, microhardness, and color stability of 3D‐printed, computer‐aided design and computer‐aided manufacturing (CAD‐CAM) milled, and heat‐polymerized denture base material (DBM).Materials and methodsA total of 420 disc‐shaped specimens (10 ±0.1 × 2 ±0.1 mm) were fabricated using three different construction techniques: three‐dimensional (3D) printing (n = 140), CAD‐CAM milling (n = 140), and heat‐polymerization (n = 140). Sixty specimens (20 of each DBM) were used for baseline (pre‐immersion) measurements (T1) for the tested surface properties [hardness (n = 10/material) and roughness (n = 10/material)]. The remaining 360 specimens (n = 120/material) were investigated for surface roughness, microhardness, and color change after immersion for 1 year (T2) in distilled water or CDCs (n = 30/solution and n = 10/test). The data were analyzed using two‐way ANOVA, one‐way ANOVA followed by post‐hoc Tukey's test at a significance level of less than 0.05.ResultsSignificant differences were observed in the effects of the tested CDCs on the surface roughness, micro‐hardness, and color stability of varying DBM specimens (P<0.05). Corega showed the highest surface roughness and color change in all DBMs while H2O2 resulted in the lowest microhardness for all DBMs. The lowest changes in all tested properties were seen with DW followed by CHX. A significant effect of CDC, DBM, and the interaction between the two was seen on all measured properties (P<0.05).ConclusionsThe tested CDCs significantly affected the surface properties of all DBMs but at varying degrees. Corega produced the highest negative effect on roughness and color change while H2O2 dramatically affected the microhardness. Prolonged use of CDCs should be cautiously followed.This article is protected by copyright. All rights reserved