Effect of depression on cognition after mild traumatic brain injury in adults

Terry, Douglas P.; Brassil, Michelle E.; Panenka, William J.; Silverberg, Noah D.

doi:10.1080/13854046.2018.1459853

Cited by 41 publications

(20 citation statements)

References 44 publications

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“…As in previous studies [ 22 , 23 ], it might be difficult for residents to report the mean number of work hours per week directly because many count their working time by day, so the mean number of working hours was calculated using the following equation with three components: mean working time on weekdays, mean working time on weekends, and number of night shifts each month.…”

Section: Methodsmentioning

confidence: 99%

Relationship Between Depression and Stress Coping Ability Among Residents in Japan: A Two-Year Longitudinal Study

et al. 2018

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BackgroundDepression among medical residents is a critical issue. The early detection of depression and provision of appropriate care is necessary for fostering healthy conditions during clinical training. To investigate whether Sense of Coherence (SOC), an indicator of stress coping ability, could be a predictor of depression 2 years after the start of clinical training, we conducted a national longitudinal study.MethodsWe distributed self-administered questionnaires to residents in 251 postgraduate educational hospitals just before the start of their clinical training. The questionnaire contained the Center for Epidemiologic Studies Depression (CES-D) scale (a screening tool for depression), the SOC scale, and demographic factors. After 2 years, we distributed questionnaires to residents who responded to the first survey. The second questionnaire contained the CES-D scale and questions about working conditions. We categorized respondents into three groups according to their SOC score and analyzed the relationship between SOC groups (low, middle, high) and depressive symptoms on the follow-up survey.ResultsIn total, 1,738 of 2,935 residents (59.2%) responded to the first survey. Of these, 1,169 residents (67.3%) also responded to the follow-up survey. A total of 169 residents were excluded because they screened positive for depressive symptoms at the time of the first survey. On the follow-up survey, 187 residents (19.5%) had new-onset depressive symptoms: 33.3% in the low SOC group, 18.2% in the middle SOC group, and 11.4% in the high SOC group (P < 0.01). Compared with the high SOC group, the odds ratio for new-onset depressive symptoms in the low SOC group was 2.04 (95% confidence interval, 1.02 - 4.05) after adjusting for demographic factors, baseline CES-D score, and mean working time.ConclusionsSOC score is significantly associated with future depressive symptoms among residents after 2 years. Residents in the low SOC group had a 2-fold higher risk of future depressive symptoms than those in the high SOC group. The SOC scale might be a useful predictor of future depression and allow for the provision of appropriate support to residents during clinical training.

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Section: Methodsmentioning

confidence: 99%

Relationship Between Depression and Stress Coping Ability Among Residents in Japan: A Two-Year Longitudinal Study

et al. 2018

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“…Бытовой и производственный травматизм, в том числе и черепно-мозговая травма (ЧМТ) -заболевания, которые являются основной проблемой общественного здравоохранения во всех промышленно развитых странах и ведут к стойкой потере трудоспособности, а также высокой смертности, инвалидизации и приводят к высоким затратам на лечение [1].…”

Section: Introductionunclassified

The Search for Neuroprotective Compounds Among New Ethylthiadiazole Derivatives

Cherevatenko

Antsiferov

Skachilova

et al. 2021

Farm. farmakol. (Pâtigorsk)

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The aim of the study is to search compounds with neuroprotective properties among new ethylthiadiazole derivatives in simulated traumatic brain injury.Materials and methods. The experiment was carried out on 78 white male rats 270±20 g line “Wistar” 5–6 months of age and 120 outbred sexually mature mice weighing 20±2 grams. The article describes the search for compounds with neuroprotective properties among new ethylthiadiazole derivatives under the codes LKHT 4–15, LKHT 10–18, LKHT 11–18, and LKHT 12–18 in experimental traumatic brain injury in rats. Acute toxicity of the compounds was studied. Pharmacological screening was performed using behavioral and neurological research methods. The McGraw stroke score scale modified by I.V. Gannushkina and the mNSS psychometric scale were used in the study. The open field and Rota-rod tests were used to assess the behavioral status of the animals.Results. The compound-LKHT 12–18 at a dose of 50 mg/kg was detected as a leader. In pharmacological correction of pathology, this compound had the lowest percentage of fatality among the studied compounds (8%), the severity of neurological deficit was significantly reduced, the lowest scores and a higher level of motor activity of the limbs were registered. The number of rearing in the group of animals receiving the compound LKHT 12–18 at the dose of 50 mg/kg increased by 1.5 times, statistically significant (p<0.05) in comparison with the control group. Based on the results of the “Rota-rod” test, the total time of holding animals on the rod for 3 attempts was statistically significantly different in the groups administered with LKHT 12–18 derivatives (1.5 times longer) at the dose of 50 mg/kg compared with the control (p<0.05).Conclusion. Based on the results obtained in this study, it is planned to study in more detail the compound LKHT 12–18 at the dose of 50 mg/kg.

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“…an acute brain injury resulting from mechanical energy to the head from external physical forces” (Carroll et al, 2004, p. 115). Mild traumatic brain injuries can result in deleterious consequences including attention, memory, learning, processing speed, and/or inhibition difficulties within the first 3 months (Terry et al, 2019). Prolonged motor deficits (Collins et al, 1999) and memory problems for years post-injury (Bedard et al, 2017) have also been noted.…”

Section: Introductionmentioning

confidence: 99%

Identifying Frequency of Mild Traumatic Brain Injury in Firefighters

Torres

Strack

Dolan

et al. 2020

Workplace Health Saf

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Background: Mild traumatic brain injury (mTBI) is a nationwide problem; yet, no firefighter mTBI data are available. Methods: In this cross-sectional study, we assessed retrospective head injuries using WHO guidelines. We captured mTBI frequency and examined firefighters’ symptoms (e.g., using Ohio State University Traumatic Brain Injury Identification method, Brief Traumatic Brain Injury Screen, Warrior Administered Retrospective Causality Assessment Tool). Findings: Of 1,112 firefighters contacted, 60 responses were included. Most participants were White (80%), male (90%), former athletes (75%). 62% met mTBI symptom criteria. 75% reported at least one lifetime head injury. Number of head injuries and depression symptoms were associated (r = .36, p < .05). Conclusion/application to practice: Overall, it appears most firefighters have sustained at least one lifetime mTBI. Those with multiple head injuries may be at increased risk of depression. Occupational health professionals should be aware of firefighters’ mTBI risk. Further research is warranted given findings.

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Effect of depression on cognition after mild traumatic brain injury in adults

Abstract: Depression is a common comorbidity and an important factor to consider when interpreting neurocognitive test performance in adults with concussion in a clinical setting.

Cited by 41 publications

References 44 publications

Relationship Between Depression and Stress Coping Ability Among Residents in Japan: A Two-Year Longitudinal Study

Relationship Between Depression and Stress Coping Ability Among Residents in Japan: A Two-Year Longitudinal Study

The Search for Neuroprotective Compounds Among New Ethylthiadiazole Derivatives

Identifying Frequency of Mild Traumatic Brain Injury in Firefighters

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