Effect of desmopressin on hemochromocytometric and clotting parameters in healthy blood donor dogs

Abstract

Six clinically healthy blood donor dogs were used to evaluate the effect of desmopressin (DDAVP) on haemochromocytometric and clotting parameters,. They received subcutaneously a physiological solution (placebo) and DDAVP (1μg/kg) with a two-weeks wash-out period between treatments. Blood samples were collected immediately before the injection, after 30 minutes, then after 1, 2, 3, 4, 5 and 6 hours. Two-way repeated measure analysis of variance (ANOVA) showed no significant effect of DDAVP vs placebo, except for white blood cell (WBC) count, and in particular on neutrophils. In conclusion, DDAVP administration in healthy donor dogs does not induce modification in blood cell count and clotting parameters, except of WBC.

Effect of desmopressin on immune-mediated haemorrhagic disorders due to canine monocytic ehrlichiosis: a preliminary study

“…Even although the aPTT and PT values were within the physiological range before the administration of DDAVP, their modifications 48 h after DDAVP infusion probably contributed to the improvements in haemostasis. This modification could also be due to a response linked to the specific pathology, since DDAVP administration does not modify clotting parameters in healthy dogs (Johnstone & Crane, 1986; Giudice et al. , 2009).…”