Effect of development of antibodies to hla and cytomegalovirus mismatch on lung transplantation survival and development of bronchiolitis obliterans syndrome

Smith, Michael A.; Sundaresan, Sudhir; Mohanakumar, T.; Trulock, Elbert P.; Lynch, John P.; Phelan, D.; Cooper, Joel D.; Patterson, G. Alexander

doi:10.1016/s0022-5223(98)00444-9

Cited by 143 publications

(94 citation statements)

References 19 publications

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“…Previous studies suggested a role for HLA antibodies after lung transplantation. [5][6][7][8]22,23 Girnita et al found that HLA antibodies are associated with increased frequency and more severe acute rejections after lung transplant, 5 as well as increased incidence of BOS. 6 Their studies had small patient cohorts and, although they used solid-phase antibody assays for HLA antibody detection, they were enzyme-linked immunoassay (ELISA)-based and, as such, probably underestimated the level of HLA antibody production.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have suggested an association between HLA antibodies detected post-transplant and acute rejection and BOS. [5][6][7][8] Girnita et al showed an association between development of HLA antibodies and acute rejection 5 and BOS 6 in a small series of lung transplants. However, their analysis was not time-dependent and did not account for time to BOS.…”

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confidence: 99%

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De novo donor HLA-specific antibodies predict development of bronchiolitis obliterans syndrome after lung transplantation

Safavi

Robinson

Soresi

et al. 2014

The Journal of Heart and Lung Transplantation

115

104

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(2014) De novo donor HLA-specific antibodies predict development of bronchiolitis obliterans syndrome after lung transplantation. The Journal of Heart and Lung Transplantation, 33 (12). pp. 1273 -1281 . ISSN 1053 -2498 This version is available from Sussex Research Online: http://sro.sussex.ac.uk/56766/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. There was a significant reduction in patient survival associated with de novo DSA (HR ¼ 1.886, p ¼ 0.047). In multivariable analyses, de novo DSA was an independent predictor for development of all stages of BOS as well as an independent predictor of poor patient survival. CONCLUSIONS: De novo DSA is a major risk factor for progression to BOS and shorter patient survival. Treatments to remove antibodies or limit antibody-mediated damage could be considered when DSA are first detected. However, a randomized, controlled trial of treatment options would enable a clearer understanding of the benefits, if any, of antibody-removal therapies.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

De novo donor HLA-specific antibodies predict development of bronchiolitis obliterans syndrome after lung transplantation

Safavi

Robinson

Soresi

et al. 2014

The Journal of Heart and Lung Transplantation

115

104

View full text Add to dashboard Cite

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“…Both direct and indirect effects are often present simultaneously, and the relative clinical contributions of any of these mechanisms are uncertain. In general, CMV seropositivity and receipt of seropositive organs and viremia are linked in many, but not all, studies to diminished long-term graft function (16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Furthermore, most studies have indicated that successful antiviral prophylaxis has a beneficial effect on long-term graft function (8).…”

Section: Introductionmentioning

confidence: 99%

The Cell Biology of Cytomegalovirus: Implications for Transplantation

Kaminski

Fishman

2016

American Journal of Transplantation

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Interpretation of clinical data regarding the impact of cytomegalovirus (CMV) infection on allograft function is complicated by the diversity of viral strains and substantial variability of cellular receptors and viral gene expression in different tissues. Variation also exists in nonspecific (monocytes and dendritic cells) and specific (NK cells, antibodies) responses that augment T cell antiviral activities. Innate immune signaling pathways and expanded pools of memory NK cells and cd T cells also serve to amplify host responses to infection. The clinical impact of specific memory T cell anti-CMV responses that cross-react with graft antigens and alloantigens is uncertain but appears to contribute to graft injury and to the abrogation of allograft tolerance. These responses are modified by diverse immunosuppressive regimens and by underlying host immune deficits. The impact of CMV infection on the transplant recipient reflects cellular changes and corresponding host responses, the convergence of which has been termed the "indirect effects" of CMV infection. Future studies will clarify interactions between CMV infection and allograft injury and will guide interventions that may enhance clinical outcomes in transplantation.

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“…Moreover, in in vitro models, CMV upregulated the expression of IL-8 in fibroblasts; this major mediator of the inflammatory response may play a role in the pathogenesis of bronchiolitis (23). patients (D À /R À ) (10,33,34,45,46 (47). A recent study from the Swiss Transplant Cohort Study (STCS), however, suggested that despite the use of universal antiviral preventive strategies, CMV-seropositive status remained associated with higher rates of biopsy-proven acute rejection compared with D À /R À patients (33).…”

Section: Viral Infections and Chronic Allograft Dysfunctionmentioning

confidence: 99%

The Impact of Infection on Chronic Allograft Dysfunction and Allograft Survival After Solid Organ Transplantation

Martín-Gandul

Mueller

Pascual

et al. 2015

American Journal of Transplantation

134

103

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Infectious diseases after solid organ transplantation (SOT) are a significant cause of morbidity and reduced allograft and patient survival; however, the influence of infection on the development of chronic allograft dysfunction has not been completely delineated. Some viral infections appear to affect allograft function by both inducing direct tissue damage and immunologically related injury, including acute rejection. In particular, this has been observed for cytomegalovirus (CMV) infection in all SOT recipients and for BK virus infection in kidney transplant recipients, for community-acquired respiratory viruses in lung transplant recipients, and for hepatitis C virus in liver transplant recipients. The impact of bacterial and fungal infections is less clear, but bacterial urinary tract infections and respiratory tract colonization by Pseudomonas aeruginosa and Aspergillus spp appear to be correlated with higher rates of chronic allograft dysfunction in kidney and lung transplant recipients, respectively. Evidence supports the beneficial effects of the use of antiviral prophylaxis for CMV in improving allograft function and survival in SOT recipients. Nevertheless, there is still a need for prospective interventional trials assessing the potential effects of preventive and therapeutic strategies against bacterial and fungal infection for reducing or delaying the development of chronic allograft dysfunction.

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Effect of development of antibodies to hla and cytomegalovirus mismatch on lung transplantation survival and development of bronchiolitis obliterans syndrome

Abstract: These data suggest that bronchiolitis obliterans syndrome is the result of an immune-mediated process in which HLA antibodies and cytomegalovirus may play a significant role.

Cited by 143 publications

References 19 publications

De novo donor HLA-specific antibodies predict development of bronchiolitis obliterans syndrome after lung transplantation

De novo donor HLA-specific antibodies predict development of bronchiolitis obliterans syndrome after lung transplantation

The Cell Biology of Cytomegalovirus: Implications for Transplantation

The Impact of Infection on Chronic Allograft Dysfunction and Allograft Survival After Solid Organ Transplantation

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