Effect of Dexamethasone Eyedrops on Blood Glucose Profile

Bahar, Irit; Rosenblat, Irit; Erenberg, Miriam; Eldar, Ido; Gaton, Dan D.; Avisar, Rahamim; Weinberger, Dov

doi:10.1080/02713680701573704

Cited by 10 publications

(8 citation statements)

References 21 publications

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“…This is due to the fact that most of our recruited patients are approximately three to five years past their initial diagnosis, and of these over half have concurrent systemic diseases such as ankylosing spondylitis (Table 1), making them even more likely to have received steroid therapy at some point. Although topical application of DEX has supposedly low systemic uptake, concentration of blood glucose levels has been shown to be increased in diabetic patients receiving DEX5657. Therefore, if a patient has received systemic steroid therapy prior to collection of blood samples, we cannot rule out potential impact on our results.…”

Section: Discussionmentioning

confidence: 93%

S100A8 promotes migration and infiltration of inflammatory cells in acute anterior uveitis

Zhang

et al. 2016

Sci Rep

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Uveitis, the pathologic condition of inflammation of the uvea, frequently leads to severe vision loss and blindness. S100A8 is a calcium-binding protein which mainly expresses in granulocytes and monocytes and plays a prominent role in the regulation of inflammatory processes and immune response. Here, we determined the role of S100A8-positive cells in acute anterior uveitis (AAU) and keratitis. In rat models of endotoxin (lipopolisaccharide, LPS) -induced uveitis (EIU) and keratitis, S100A8-positive granulocytes and monocytes increased significantly in the iris-ciliary body and cornea as well as in the blood. Interestingly, Glucocorticoids slightly increased S100A8 levels in leukocytes, but reduced its presence significantly in the iris-ciliary body after LPS injection. Moreover, inhibition of NF-kB activation remarkably suppressed both progression of AAU and total S100A8 levels in leukocytes and the iris-ciliary body after LPS administration. Additionally, S100A8 protein level was also found to be elevated in the serum of AAU patients parallel with the progression of AAU through the designated clinical stages. Thus, S100A8 plays a pivotal role in the processes of AAU through involvement in migration and infiltration of S100A8-positive cells. Our findings suggest that serum levels of S100A8 protein can be used to monitor inflammatory activity in AAU.

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Section: Discussionmentioning

confidence: 93%

S100A8 promotes migration and infiltration of inflammatory cells in acute anterior uveitis

Zhang

et al. 2016

Sci Rep

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“…Two were letters to the editor (Barequet 2004; Rocha 2009), one had no comparison group (Carenini 1993), one modeled existing trial data (Mullins 2016), two studies reported on a mix of surgeries for various eye conditions (Maheshwari 1995; Yasuda 2016), one was a dosage study (NCT00758199), and one used oral rather than topical corticosteroids (Sabiston 1987). We excluded one other study because the report was not intended to assess vision outcomes (Bahar 2007). …”

Section: Resultsmentioning

confidence: 99%

Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery

Juthani

Clearfield

Chuck

2017

Cochrane Database of Systematic Reviews

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“…Of note, most patients requiring non‐steroidal anti‐inflammatory drugs for pain control show a high incidence of gastrointestinal and cardiovascular risk factors [140]. Steroidal anti‐inflammatory drugs increase blood glucose levels, for example dexamethasone [141]. Therefore, it may be inappropriate to use potent anti‐inflammatory drugs to prevent the development of diabetes.…”

Section: Tcm With Anti‐inflammatory Effects Onlymentioning

confidence: 99%

Diabetes is an inflammatory disease: evidence from traditional Chinese medicines

Xie

2011

Diabetes, Obesity and Metabolism

275

182

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Diabetes is usually associated with inflammation. Inflammation contributes to the development of diabetes. Traditional Chinese medicines (TCM) play an important role in lowering blood glucose and controlling inflammation. Many studies show that TCM with hypoglycaemic effects, for example Radix Astragali, Radix Rehmanniae, Radix Trichosanthis, Panax Ginseng, Fructus Schisandrae, Radix Ophiopogonis, Rhizoma Anemarrhenae, Radix Puerariae, Fructus Lycii, Poria, Rhizoma Coptidis, Rhizoma Dioscoreae, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Semen Trigonellae, Momordica charantia, Allium sativum, Opuntia stricta, Aloe vera, Cortex Cinnamomi, Rhizoma Curcumae Longae, and so on, have nearly independent anti-inflammatory action. Antihyperglycaemic compounds, for example berberine, puerarin, quercetin, ferulic acid, astragaloside IV, curcumin, epigallocatechin gallate, resveratrol, tetrandrine, glycyrrhizin, emodin and baicalin, used in TCM also have anti-inflammatory effects. These studies suggest that TCM might exert hypoglycaemic effects that are partly mediated by the anti-inflammatory mechanisms. However, small amounts of TCM with potent anti-inflammatory action does not have any hypoglycaemic effect. This indirectly indicates that diabetes may be a low-grade inflammatory disease and potent regulation of inflammatory mediators may not be required. Studies of TCM add new evidences, which indicate that diabetes may be an inflammatory disease and slight or moderate inhibition of inflammation might be useful to prevent the development of diabetes. Through this review, we aim to develop more perspectives to indicate that diabetes may be an inflammatory disease and diverse TCM may share a common antidiabetic property: anti-inflammatory action. Further studies should focus on and validate inflammation-regulating targets of TCM that may be involved in inhibiting the development of diabetes.

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Effect of Dexamethasone Eyedrops on Blood Glucose Profile

Abstract: Postoperative dexamethasone eyedrops have a greater effect on the blood glucose profile of diabetic patients than on nondiabetic patients. Clinicians should be alerted to this risk and may initiate appropriate follow-up in this patient subgroup.

Cited by 10 publications

References 21 publications

S100A8 promotes migration and infiltration of inflammatory cells in acute anterior uveitis

S100A8 promotes migration and infiltration of inflammatory cells in acute anterior uveitis

Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery

Diabetes is an inflammatory disease: evidence from traditional Chinese medicines

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