Effect of Dexamethasone on Resting Blood Lactate Concentrations in Horses

Mizen, Kelvin; Woodman, Jessica; Boysen, Søren; Wagg, Catherine; Greco‐Otto, Persephone; Léguillette, Renaud; Roy, Marie-France

doi:10.1111/jvim.14630

Cited by 7 publications

(12 citation statements)

References 32 publications

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“…33,34 A similar association between obesity, ID, and increased blood l-lactate concentrations could therefore be present in equids leading to the hypotheses that blood l-lactate concentrations are higher in ponies with increased autumnal ACTH concentrations or evidence of ID and would correlate with measures of endocrine health. 35,36 However, contrary to findings in people, a negative correlation between l-lactate concentrations and average BCS 32 was detected in ponies in the present study and no correlation with baseline insulin, insulin concentrations 60 minutes after an OST, adiponectin, triglycerides, or ACTH concentrations could be established. There might be several explanations why results of our study did not support the hypotheses.…”

Section: Discussioncontrasting

confidence: 99%

“…38 Although a positive relationship between blood glucose and l-lactate concentrations was identified and increases in both variables were timely associated in the study in horses, it could not be determined whether hyperglycemia was a prerequisite for the development of hyperlactatemia. 35 All ponies in our study were clinically healthy and hyperglycemia was not detected in any of the ponies. This suggests that any endocrine abnormalities were well compensated and not severe enough to result in clinical signs.…”

Section: Discussionmentioning

confidence: 59%

“…Steroid hormones appear to have a major influence on l‐lactate metabolism and free cortisol concentrations are increased in overweight and obese equids 37 . Administration of exogenous corticosteroids to cardiac surgery patients and healthy horses decreased insulin sensitivity and increased blood glucose and l‐lactate concentrations 35,38 . In the study involving human cardiac patients, increased blood l‐lactate concentrations appeared to be dependent on the presence of hyperglycemia 38 .…”

Section: Discussionmentioning

confidence: 98%

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Influence of endocrine disease on l‐lactate concentrations in blood of ponies

Dunkel

Knowles

Chang

et al. 2021

Veterinary Internal Medicne

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Background: Blood l-lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objectives: To investigate whether blood l-lactate concentrations are positively correlated with measures of insulin dysregulation (ID) or increased autumnal ACTH concentrations in ponies. Animals: Systemically healthy client-owned ponies (n = 101). Methods: Prospective case-control study. Blood samples were obtained from 101 clinically healthy ponies. Breed, weight, height, and subjective and objective measures of body condition were recorded. Blood l-lactate, glucose, triglyceride, total adiponectin, and ACTH concentrations were measured and an oral sugar test (OST) was carried out. Correlations between blood l-lactate and variables of endocrine health were determined.Results: Using a seasonal cutoff point of ACTH concentrations ≥47 pg/mL, 55 ponies had increased autumnal ACTH concentrations and 45 did not. Using a basal insulin concentration of >50 μiU/mL, 42 ponies were diagnosed with ID and 58 were not. Using a 60 minutes after OST cutoff point of >45 μiU/mL, 57 ponies had ID and 37 did not. Blood l-lactate concentrations were significantly lower in obese (average body condition score ≥ 7/9

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 98%

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Influence of endocrine disease on l‐lactate concentrations in blood of ponies

Dunkel

Knowles

Chang

et al. 2021

Veterinary Internal Medicne

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“…Use of dexamethasone (0.05 mg/kg IM q24h, 7 days) also results in a clinically irrelevant increase in blood lactate. 127 Glucocorticoids alter calcium metabolism by increasing urinary excretion and decreasing gastrointestinal absorption 129 along with an inhibition of calcium release from bones. 130 Because administration of GC to human patients is associated with osteoporosis, this effect was investigated in pony foals where prolonged treatment (>3 months) with dexamethasone (0.005-0.05 mg/kg q24h IM) led to osteonecrosis.…”

Section: Metabolic Effectsmentioning

confidence: 99%

“…Use of dexamethasone (0.05 mg/kg IM q24h, 7 days) also results in a clinically irrelevant increase in blood lactate. 127 …”

Section: Adverse Effectsmentioning

confidence: 99%

Glucocorticoid treatment in horses with asthma: A narrative review

Mainguy-Seers

Lavoie

2021

Veterinary Internal Medicne

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Despite substantial research efforts to improve the treatment and outcome of horses with asthma, glucocorticoids (GC) remain the cornerstone of drug treatment of this prevalent disease. The high efficacy of GC to relieve airway obstruction explains their extensive use despite potential deleterious effects. However, much is yet to be uncovered concerning GC use in horses with asthma, including the comparative efficacy of the different drugs, the determination of minimal effective doses and the mechanisms underlying their variable modulation of airway inflammation. The objectives of this structured review were to report and compare the plethora of effects of the various GC used in asthmatic horses with a focus on impact on lung function, airway inflammation, and bronchial remodeling. Adverse effects are also briefly described, with an emphasis on those that have been specifically reported in horses with asthma. Ultimately, we aimed to highlight gaps in the literature and to identify future research areas.

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Hyperlactatemia After Intracranial Tumor Surgery Does Not Affect 6-Month Survival: A Retrospective Case Series

Smalen¹,

Ark²,

Stolker³

et al. 2020

Journal of Neurosurgical Anesthesiology

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Background: Patients undergoing neurosurgery frequently exhibit hyperlactatemia. The aim of this study was to identify factors associated with hyperlactatemia and assess how hyperlactatemia impacts survival and hospital length of stay after intracranial tumor surgery. Materials and Methods: This retrospective cohort study included 496 adult patients that underwent surgery between January 1, 2014 and December 31, 2015. We evaluated patient characteristics, surgery characteristics, pH, lactate, and blood glucose from blood samples collected on admission to the high-dependency unit and the morning after surgery, and 6-month outcome data. Results: Hyperlactatemia (>2.0 mmol/L) occurred in >50% of patients, but only 7.7% had acidosis. Postoperative hyperlactatemia was not correlated with 6-month survival (P=0.987), but was correlated with (median [interquartile range]) longer hospital stays (6 [4 to 8.5] d vs. 5 [4 to 8] d; P=0.006), longer surgery duration (4:53 [4:01 to 6:18] h:min vs. 4:28 [3:33 to 5:53] h:min; P=0.001), higher dexamethasone dose (16 [16 to 35] mg vs. 16 [16 to 20] mg; P<0.001), and higher blood glucose concentration (8.4 [7.5 to 9.6] mmol/L vs. 8.0 [7.1 to 8.9] mmol/L; P<0.001). Patients that received total intravenous anesthesia developed hyperlactatemia less frequently than those that received balanced anesthesia with inhalational agents (48.4% vs. 61.5%, P=0.008). Hyperlactatemia was not associated with increased postoperative neurological deficits or the need for rehabilitation therapy. Conclusions: Hyperlactatemia was common after intracranial tumor surgery. It did not influence 6-month outcomes but was associated with longer hospital length of stay. Several potential causative factors for hyperlactatemia were identified.

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Effect of Dexamethasone on Resting Blood Lactate Concentrations in Horses

Cited by 7 publications

References 32 publications

Influence of endocrine disease on l‐lactate concentrations in blood of ponies

Influence of endocrine disease on l‐lactate concentrations in blood of ponies

Glucocorticoid treatment in horses with asthma: A narrative review

Hyperlactatemia After Intracranial Tumor Surgery Does Not Affect 6-Month Survival: A Retrospective Case Series

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