Effect of dexmedetomidine on propofol requirements in healthy subjects

Dutta, Sandeep; Karol, Michael D.; Cohen, Theodora; Jones, Ron N. M.; Mant, Timothy

doi:10.1002/1520-6017(200102)90:2<172::aid-jps8>3.0.co;2-j

Cited by 89 publications

(76 citation statements)

References 12 publications

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“…It has become increasingly popular among anesthesiologists and intensive care physicians as an adjuvant to the classical regimen of anesthesia techniques (Paris and Tonner 2005). Also, it has been shown to reduce the anesthetic and analgesic requirements in animals and humans (Khan et al 1999;Dutta et al 2001). The anesthetic-sparing activity of Dex was demonstrated almost exclusively using hemodynamic criteria to assess anesthetic depth in many studies.…”

Section: Discussionmentioning

confidence: 97%

Hemodynamic and Anesthetic Advantages of Dexmedetomidine, an .ALPHA.2-Agonist, for Surgery in Prone Position

Özköse

Demir

Pampal

et al. 2006

Tohoku J. Exp. Med.

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The α 2-agonist dexmedetomidine (Dex), a sedative and analgesic, reduces heart rate (HR) and blood pressure, and has been used in the practice of anesthesia. In this study, we aimed to evaluate the effects of Dex on hemodynamic variables, anesthetic sparing effects, and recovery profiles in patients who underwent surgery in prone position. The prone position itself can cause a decrease in the systemic blood pressure. Forty patients who undergo lumbar discectomy were randomly assigned to receive either Dex (a loading dose 1 μ g/ kg in 10 minutes followed by an infusion rate of 0.2 μ g/ kg/ hr) or saline. In both groups, the anesthesia was induced with fentanyl, thiopental and rocuronium, and maintained with desflurane in 50% N 2 O. Mean arterial blood pressure (MAP), HR, cardiac output (CO), and level of anesthesia were monitored. Recovery times and analgesic requirements were also recorded. As a response to endotracheal intubation, a significant increase in MAP and HR was observed in the control group compared to the Dex group, but no difference in CO. The recovery times were significantly shorter in the Dex group compared to the control group. Anesthetic and analgesic requirements of the Dex group were lower than controls. Thus, the use of Dex caused no detrimental effects on the hemodynamic variables in prone position. In addition, Dex decreased pressure response to intubation, and anesthetic and analgesic requirements, shortened recovery times, and decreased postoperative pain level. Dex may be an alternative to currently used adjunctive anesthetic agents in lumbar discectomy operations.anesthesia; dexmedetomidine; NICO; cardiac output; lumbar discectomy

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Section: Discussionmentioning

confidence: 97%

Hemodynamic and Anesthetic Advantages of Dexmedetomidine, an .ALPHA.2-Agonist, for Surgery in Prone Position

Özköse

Demir

Pampal

et al. 2006

Tohoku J. Exp. Med.

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show abstract

“…In our study, 2 patients Previous studies reported that use of DEX prior to general anesthesia lowered the required dose of thiopental and propofol by 37% and 80%, respectively [12,13]. In our study, the same amount of propofol (2.0 mg/kg) was administered to both groups and group D exhibited a 20% lower BIS value than group S did.…”

Section: Discussionmentioning

confidence: 99%

Pre-anesthetic sedative effect of dexmedetomidine in laparoscopic cholecystectomy performed under general anesthesia

et al. 2018

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“…In patients of both groups, if any discomfort, agitation or unexpected movement occurred, incremental bolus of propofol (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) mg was given.…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of Dexmedetomidine as an Adjunct Agent for Sedation during ERCP

Mahmoud¹,

Hasanin²,

Abdel-Razek³

2016

J Anesth Clin Res

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Objectives: To evaluate dexmedetomidine as an adjunct drug to propofol for sedation during ERCP, and its effects on perfusion index (PI) which could be used as an indicator for analgesia level.Methods: 76 patients ASA (I-III) scheduled for ERCP procedure were randomly classified to either dexmedetomidine/propofol group or propofol group. In dexmedetomidine/propofol group, sedation was induced by dexmedetomidine (0.7 µg/kg) and propofol (50 mg) followed by infusion of dexmedetomidine (0.4 µg/kg/h) and propofol (0.5-1 mg/kg/h). In propofol group, sedation was induced by propofol (50 mg) followed by propofol infusion (0.5-1 mg/kg/h). HR, SBP, DBP, RR, SPO2 and PI were continuously monitored and recorded at the time points (T0 to T8). Results:Comparing dexmedetomidine/propofol group versus propofol group; PI values showed significant increase at T2 to T7 (p˂0.001), HR values showed significant decrease at T1 to T8 (p 0.013 at T1 and 0.001 at T2 to T8), SBP values showed significant decrease at T1 to T8 (p=0.002 at T1, 0.001 at T2 to T7 and 0.004 at T8) and DBP values showed significant decrease at T4 to T6 (p value 0.008, 0.002 and 0.003 at T4.T5 and T6). RR and SPO 2 values were comparable in both groups. In dexmedetomidine/propofol group, the propofol dosage was significantly lower (p value 0.001) and the recovery time was significantly higher (p value 0.001) than that of propofol group, while the procedure time was comparable between both groups. Dexmedetomidine/propofol group showed higher incidence of bradycardia than propofol group (p value 0.035) while propofol group showed more cases with tachycardia (p value 0.016) and more cases with airway obstruction (p value 0.026).Conclusion: dexmedetomidine is a useful adjunct drug for sedation during ERCP procedure.

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Effect of dexmedetomidine on propofol requirements in healthy subjects

Cited by 89 publications

References 12 publications

Hemodynamic and Anesthetic Advantages of Dexmedetomidine, an .ALPHA.2-Agonist, for Surgery in Prone Position

Hemodynamic and Anesthetic Advantages of Dexmedetomidine, an .ALPHA.2-Agonist, for Surgery in Prone Position

Pre-anesthetic sedative effect of dexmedetomidine in laparoscopic cholecystectomy performed under general anesthesia

Effectiveness of Dexmedetomidine as an Adjunct Agent for Sedation during ERCP

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