2017
DOI: 10.1016/j.vaa.2017.07.004
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Effect of dexmedetomidine on the minimum infusion rate of propofol preventing movement in dogs

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Cited by 14 publications
(12 citation statements)
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“…In contrast, fentanyl combined with medetomidine significantly reduced the MIR NM of propofol. Dexmedetomidine, an α 2 -adrenergic receptor agonist, 2 µg/kg/hr was reported to reduce the MIR NM of propofol significantly; however, 1 µg/kg/hr of dexmedetomidine did not significantly reduce the propofol MIR NM in dogs [ 27 ]. Dexmedetomidine is an optical enantiomer of medetomidine and its sedative properties are similar to those of medetomidine.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In contrast, fentanyl combined with medetomidine significantly reduced the MIR NM of propofol. Dexmedetomidine, an α 2 -adrenergic receptor agonist, 2 µg/kg/hr was reported to reduce the MIR NM of propofol significantly; however, 1 µg/kg/hr of dexmedetomidine did not significantly reduce the propofol MIR NM in dogs [ 27 ]. Dexmedetomidine is an optical enantiomer of medetomidine and its sedative properties are similar to those of medetomidine.…”
Section: Discussionmentioning
confidence: 99%
“…Smith et al . [ 27 ] reported that dexmedetomidine significantly decreased propofol MIR NM in dogs, and a combination of α 2 -adrenoceptor agonists and opioids, such as fentanyl, produced antinociceptive effects additively or synergistically in rats [ 19 , 20 ]. These findings suggested that fentanyl and medetomidine at a constant rate in combination with propofol TIVA would be suitable for obtaining antinociceptive effects as well as a potent propofol-sparing effect.…”
mentioning
confidence: 99%
“…Continuous infusions from 1 to 2 µg/kg/h dexmedetomidine in dogs reduced the propofol requirement by approximately 36%, also providing cardiovascular stability. 18 Although the reduction in the propofol CRI is mainly caused by the presence of dexmedetomidine, the use of intraoperative fentanyl may have influenced the results. However, it is important to note that a propofol-sparing effect was still observed for the first 60 mins of anesthesia, when no fentanyl was administered.…”
Section: Discussionmentioning
confidence: 99%
“…17 Regarding the quality of recovery, dexmedetomidine has been shown to reduce vocalization, tremors and other involuntary reactions in the postanesthetic period. [18][19][20][21] However, few studies have investigated the effect of dexmedetomidine on propofol infusion requirements and on postoperative analgesia in cats.…”
Section: Introductionmentioning
confidence: 99%
“…In humans undergoing craniotomy, intraoperative constant-rate infusion of dexmedetomidine reduced postoperative pain, the consumption of other analgesic agents, and frequently occurring complications like nausea and vomiting [ 10 ] as well as hypertension and tachycardia [ 11 ]. In different animal species, dexmedetomidine significantly reduces the minimal alveolar concentration (MAC) of inhalant anaesthetics [ 12 , 13 , 14 ] and the minimum infusion rate of anaesthetics used for total intravenous anaesthesia [ 15 ]. Beside the intraoperative administration, dexmedetomidine in humans is frequently utilised for neurointensive care as it allows analgesia without respiratory depression and provides neuroprotection and haemodynamic stability [ 16 , 17 ].…”
Section: Introductionmentioning
confidence: 99%