Effect of dexmedetomidine supplementation for thoracoscopic surgery: a meta-analysis of randomized controlled trials

Song, Chengjun; Lu, Qicheng

doi:10.1186/s13019-022-01803-z

Cited by 5 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have confirmed that the combination of dexmedetomidine and local anaesthetics can produce better analgesic and sedative effects, for example, Blaudszun et al 46 found that intraoperative dexmedetomidine significantly reduced postoperative pain without causing delayed awakening, reduced the dosage of postoperative analgesics and reduced the incidence of adverse effects such as nausea and vomiting. Song et al 47 conducted a study in thoracic surgery and found that dexmedetomidine supplementation during thoracoscopic surgery greatly improved analgesia in thoracoscopic surgery. Dexmedetomidine is an effective adjuvant for prolonging the peripheral nerve blocking effect of local anaesthetics, 48 which induces depolarisation of the presynaptic membrane of the noradrenergic pathway in the blueprint and down the spinal cord 49 .…”

Section: Discussionmentioning

confidence: 99%

Utility of dexmedetomidine on surgical site wound pain undergoing thoracoscopic surgery: A meta‐analysis

Li,

Zhang,

et al. 2023

International Wound Journal

View full text Add to dashboard Cite

We conducted this study aimed to evaluate the analgesic effect of dexmedetomidine in thoracoscopic surgery on postoperative wound pain, and to provide a reference for clinical use of the drug. We searched PubMed, Embase, Cochrane Library, Web of Science, Wanfang, Chinese Biomedical Literature Database and China National Knowledge Infrastructure databases, and supplemented with manual searching. We searched from database inception to October 2023, to collect the randomised controlled trials (RCTs) on dexmedetomidine application in thoracoscopic surgery. Two researchers screened all the literature according to the inclusion and exclusion criteria and the literature included in the study was evaluated for quality, extracted information and required data. Stata 17.0 software was employed for data analysis and the outcomes were 2 6, 12, 24 and 48 h postoperative wound visual analog scores (VAS). Twenty‐four RCTs totalling 2246 patients undergoing thoracoscopic surgery were finally included. The analysis revealed dexmedetomidine applied to thoracoscopic surgery significantly reduced the postoperative wound VAS scores at 2 h (SMD: −0.96, 95% CI: −1.57 to −0.36, p = 0.002), 6 h (SMD: −0.98, 95% CI: −1.27 to −0.69, p < 0.001), 12 h (SMD: −1.19, 95% CI: −1.44 to −0.94, p < 0.001), 24 h (SMD: −0.91, 95% CI: −1.16 to −0.66, p < 0.001) and 48 h (SMD: −0.75, 95% CI: −1.02 to −0.48, p < 0.001). Our results suggest dexmedetomidine applied to thoracoscopic surgery can significantly reduce postoperative wound pain, which is worthy of clinical application.

show abstract

Section: Discussionmentioning

confidence: 99%

Utility of dexmedetomidine on surgical site wound pain undergoing thoracoscopic surgery: A meta‐analysis

Li,

Zhang,

et al. 2023

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…The proper tube position was confirmed by auscultation and fiberoptic bronchoscopy. The ventilation settings during surgery were tidal volume ( 7-10 mL kg -1 (ideal body weight) ), a fraction of inspired oxygen (0.5-1.0), and end-tidal CO 2 partial pressure (35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45). Following surgery, patients were admitted to the Intensive Care Unit (ICU).…”

Section: Methodsmentioning

confidence: 99%

“…Hamed et al showed that adding dexmedetomidine in ultrasound-guided ESPB is associated with a better analgesic effect by reducing intraoperative fentanyl and postoperative morphine consumption with a more prolonged analgesic effect and stable hemodynamics (39). Also, Song and Lu in a meta-analysis of randomized controlled trials reported that dexmedetomidine administered before anesthesia in thoracoscopic surgery can substantially improve the analgesic efficacy (40). The study in which dexmedetomidine and dexamethasone were compared in prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy (the patients received either single dose of dexmedetomidine or dexamethasone before skin incision) demonstrated that the patients in dexmedetomidine group had lower severity of pain, higher sedation score, requested the first analgesic postoperatively later, and the amount of postoperative administrated tramadol was lower (41).…”

Section: Impact Of Dexmedetomidine and Dexamethasone On Postoperative...mentioning

confidence: 99%

Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery

Peršec,

Šribar,

Ilić

et al. 2023

Acta Pharmaceutica

View full text Add to dashboard Cite

The aim of this study was to compare the effects of dexmedetomidine and dexamethasone as adjuvants to preoperative epidural administration of local anesthetic (ropivacaine) in thoracic surgery on the postoperative level of pain, use of analgesics, inflammation, and oxidative stress. The study enrolled 42 patients who underwent elective thoracic surgery in a one-year period at the University Hospital Dubrava (Zagreb, Croatia). Based on a computer-generated randomization list the patients were assigned to the dexmedetomidine (n = 18) or dexamethasone (n = 24) group. Postoperatively, patients of dexmedetomidine group reported lower pain (VAS value 1 h post surgery, 3.4 ± 2.7 vs. 5.4 ± 1.8, dexmedetomidine vs. dexamethasone, p < 0.01) and had lower anal-gesic requirements in comparison with dexamethasone group. Thus, dexmedetomidine in comparison with dexamethasone was more efficient in lowering pain and analgesia requirements 24 h after the surgery. On the contrary, dexamethasone had better anti-inflammatory properties (CRP level 24 h post surgery, 131.9 ± 90.7 vs. 26.0 ± 55.2 mg L−1, dexmedetomidine vs. dexamethasone, p < 0.01). Both dexmedetomidine and dexamethasone exhibited antioxidant effects, however, their antioxidant properties should be further explored. The results of this study improve current knowledge of pain control in thoracic surgery.

show abstract

“…Midazolam and propofol are commonly applied anesthetics in elderly patients during surgery. The combination of these two agents has a good anesthetic outcome, but it cannot effectively protect organ functions[ 4 , 5 ]. Dexmedetomidine is a highly selective α2 receptor agonist, which has a good effect in reducing the body's stress response and in stabilizing the patient's intraoperative hemodynamics.…”

Section: Introductionmentioning

confidence: 99%

Dexmedetomidine-induced anesthesia in elderly patients undergoing hip replacement surgery

Li¹,

Yuan²,

Wang³

et al. 2023

World J Clin Cases

View full text Add to dashboard Cite

BACKGROUND A femoral neck fracture is a common and frequently reported issue in orthopedics, with a greater rate of incidence among the elderly. Due to their advanced age and the presence of some primary diseases, both anesthesia and surgery are increasingly difficult in elderly patients with a femoral neck fractures. In fact, general anesthesia can easily induce complications such as cognitive dysfunction, which is not conducive to postoperative recovery. AIM To analyze the efficacy of dexmedetomidine in inducing anesthesia for elderly patients undergoing hip replacement surgery. METHODS A total of 98 elderly patients undergoing hip replacement in our hospital from June 2020 to June 2021 were randomly divided into control group (49 cases) and observation group (49 cases). The control group was given general anesthesia, and the observation group was combined with dexmedetomidine for anesthesia on the basis of the control group. Both groups were observed until the patients were discharged. The vital signs, serum inflammatory factors and renal function indexes of the two groups were compared before, during and 6 h after operation. The postoperative recovery and adverse events of the two groups were statistically analyzed. RESULTS Compared with the mean arterial pressure of the two groups, the intraoperative and postoperative 6 h was higher than that before the operation, the intraoperative was lower than the postoperative 6 h ( P < 0.05); the blood oxygen saturation of the two groups was higher than that before operation and 6 h after operation, and the observation group was higher than the control group 6 h after operation ( P < 0.05). The heart rate of the two groups was lower during and 6 h after operation than that before operation, and higher at 6 h after operation than that during operation ( P < 0.05). The levels of serum C-reactive protein, tumor necrosis factor-α, interleukin-1β and kidney injury molecule-1 in the two groups were higher during operation and 6 h after operation than those before operation ( P < 0.05). The level of serum urea nitrogen in the two groups was higher than that before operation, and that in the observation group was lower than that in the control group ( P < 0.05). During hospitalization, the first time of getting out of bed, recovery time of grade II muscle strength, recovery time of grade III muscle strength and hospitalization time in the observation group were shorter than those in the control group ( P < 0.05). CONCLUSION Dexmedetomidine can effectively improve the vital signs of elderly patients undergoing hip replacement surgery, reduce the body's inflammatory response and renal function damage, and promote postoperative recovery. Meanwhile, dexmedetomidine showcased a good safety pr...

show abstract

Effect of dexmedetomidine supplementation for thoracoscopic surgery: a meta-analysis of randomized controlled trials

Cited by 5 publications

References 41 publications

Utility of dexmedetomidine on surgical site wound pain undergoing thoracoscopic surgery: A meta‐analysis

Utility of dexmedetomidine on surgical site wound pain undergoing thoracoscopic surgery: A meta‐analysis

Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery

Dexmedetomidine-induced anesthesia in elderly patients undergoing hip replacement surgery

Contact Info

Product

Resources

About