Effect of dexpanthenol on wound healing in penile fracture model: An experimental study

Abstract

Objectives:In the present study, we aimed to investigate the effect of dexpanthenol on wound healing at the histopathological level on cavernous tissue. Materials and methods: Forty-four Wistar albino rats weighing 220-250 g were used. The rats were randomly divided into four groups as Group B, Group S, Group LD, and Group SD. In Group B, the incision was not repaired and left to secondary healing. In Group S, the incision line was repaired with 5/0 polyglactin suture. In Group LD, 0.25 mg/kg dexpanthenol was applied subcutaneously below the repaired wound region once a day during 14 days. In Group SD, 500 mg dexpanthenol was applied intraperitoneally once a day during 14 days. Results: No fibrosis was observed in 8 (80%) rats in group SD. Fibrosis rates were significantly lower in Group SD compared to Group B, Group S, and Group LD (p = 0.013, p = 0.005, and p = 0.003, respectively). Conclusion: Systemic dexpanthenol administration significantly decreased fibrosis in penile fracture model on rats.

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

“…[22] Various studies have evaluated wound healing after PF in the English literature. [6,7,21,[23][24][25] Scar tissue development has been reported in 25% of patients in the area after PF repair. [26] Due to the positive effects on wound healing, we examined the topical effect of a solution obtained from the freeze-dried powder form of AV.…”