Effect of Dextran infusion on the Adenosine Diphosphate Induced Adhesiveness and the Spreading Capacity of Human Blood Platelets

Abstract

SummaryThe adenosine diphosphate induced platelet adhesiveness to glass and the platelet spreading capacity on a siliconized glass surface have been studied in 8 hypovolemic subjects after infusion of 500 ml 6% solution of dextran 70 (Macrodex®) or 500 ml normal saline. Infusion of dextran caused a significant decrease in platelet adhesiveness compared with the controls while no effect was noted on the spreading capacity.It is proposed that the observed effect on platelet adhesiveness is due to dextran induced changes in the activity of plasma factors involved in the mechanisms leading to platelet adhesiveness.

Separation of Platelet Rich Plasma and Red Cells with Modified Gelatin

“…However, we were not able to produce evidence of any change in platelet behaviour by in vitro or in vivo tests after a load of 60 g modified gelatin (1,500 ml of Physiogel®) in a total of 39 subjects. In contrast to this, the infusion of 60 g clinical dextran (1,000 ml of Macrodex®) in 32 pa tients produced a significant increase of the Ivy bleeding time, and in a group of six further subjects an inhibition of platelet aggregation by ADP, as previously observed by other investigators [8,17,25].…”

Haemostasis in the Microvasculature of the Rabbit Mesentery, Effects of some Pharmacological Agents of Current Interest in Haemostasis and Thrombosis

“…It is known that platelet reactivity is influenced by dextran, the maximum effect being reached about 4 h after infusion [18,20]. In this study PHT and THT were significantly prolonged when dextran was given 3 h prior to anaesthesia in a dose of 2 g/kg.…”

Combined Administration of Dextran 70 and Dalteparin Does Not Increase Perioperative Blood Loss Compared to Dextran 70 Alone in Major Orthopedic Surgery

“…However, dextran improves macro-and microcirculatory flow [6,7] and modifies the coagulation system in other ways than LMWH [8][9][10][11][12][13][14][15]. It decreases von Willebrand factor [16], alters the fibrin structure which becomes more fragile, reduces platelet aggregation, coats vascular surfaces, prevents leukocyte trapping, favors fibrinolysis and has a colloid osmotic effect which increases the blood flow [10,15,[17][18][19][20]. Dextran even reduces pulmonary embolism more than it prevents deep vein thrombosis [21], probably by making the fibrin structure more fragile and easily lysed [18].…”