Effect of Diabetes and of 7α-Hydroxycholesterol Infusion on the Profile of Bile Acids Secreted by the Isolated Rat Livers

Ogura, Yoshio; Iwamoto, Toshihiko; Ogura, Michio

doi:10.1515/bchm3.1986.367.2.1095

Cited by 13 publications

(4 citation statements)

References 6 publications

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“…The potential association of bile acid profile with diabetic state has been acknowledged for decades [ 49 ], yet the consequences of this interaction appear to have remained relatively underappreciated. In addition to the role of bile-mediated FXR signaling in correcting obesity, there are indications that this pathway may also impact insulin sensitivity [ 50 ].…”

Section: Bile Modulates Host Metabolic Functionmentioning

confidence: 99%

Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions

Ryan

Stanton

Caplice

2017

Diabetol Metab Syndr

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While basic and clinical research over the last several decades has recognized a number of modifiable risk factors associated with cardiometabolic disease progression, additional and alternative biological perspectives may offer novel targets for prevention and treatment of this disease set. There is mounting preclinical and emerging clinical evidence indicating that the mass of metabolically diverse microorganisms which inhabit the human gastrointestinal tract may be implicated in initiation and modulation of cardiovascular and metabolic disease outcomes. The following review will discuss this gut microbiome–host metabolism axis and address newly proposed bile-mediated signaling pathways through which dysregulation of this homeostatic axis may influence host cardiovascular risk. With a central focus on the major nuclear and membrane-bound bile acid receptor ligands, we aim to review the putative impact of microbial bile acid modification on several major phenotypes of metabolic syndrome, from obesity to heart failure. Finally, attempting to synthesize several separate but complementary hypotheses, we will review current directions in preclinical and clinical investigation in this evolving field.

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Section: Bile Modulates Host Metabolic Functionmentioning

confidence: 99%

Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions

Ryan

Stanton

Caplice

2017

Diabetol Metab Syndr

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“…In non-diabetic rats , it has been shown that they have a higher percentage of β-MCA a 7-hydroxylated BA and lesser CA a 7hydroxylated BA while diabetic rats show the reverse. In these diabetic rats normal BA profile was restored by insulin administration (Ogura, Ito et al 1986). Research on BA profile may help in therapeutic research for diabetic patients.…”

Section: Chapter 7 Summary and Future Studiesmentioning

confidence: 88%

The role of glucocorticoid metabolism in bile acid homeostasis

Opiyo¹,

Escher²,

Kenyon³

et al. 2014

EJEA

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“…This interaction between bile acid composition and the composition of gut microflora represents the base of the hypothesized link between bile acid, gut microflora and energy balance. However, even though the compositions of bile acids and gut microflora are reported to be different in diabetic patients (Duan et al 2008;Gebel 2011;Morris 1989;Ogura et al 1986;Slivka et al 1979a;Thomson 1983), it is still not clear how these changes directly affect the development and progression of diabetes or its complications. These complications include cardiovascular, tissue necrosis and ulcerations, and metabolic disturbances.…”

Section: Diabetes-associated Disturbances In Bile Acids and Gut Micromentioning

confidence: 99%

“…So despite strict glycemic control, the disease and its complications remain a growing health concern. Diabetic patients suffer complications due to disturbed physiological and biochemical processes associated with the disease including disturbed bile acids production and microfloral composition (Barbeau et al 2006;Ogura et al 1986;Peng & Hagopian 2007;Rozanova et al 2002;Slivka et al 1979a;Thomson 1983). Thus the use of bile acids and probiotics in diabetes treatment may improve glycemia as well the ameliorate complications.…”

Section: Introductionmentioning

confidence: 99%