Effect of Diabetes Mellitus and Left Ventricular Perfusion on Frequency of Development of Heart Failure and/or All-cause Mortality Late After Acute Myocardial Infarction

Tomasik, Andrzej; Nabrdalik, Katarzyna; Kwiendacz, Hanna; Radzik, Edyta; Pigoń, Katarzyna; Młyńczak, Tomasz; Sawczyn, Tomasz; Gumprecht, Janusz; Nowalany-Kozielska, Ewa; Lip, Gregory Y. H.

doi:10.1016/j.amjcard.2020.10.051

Cited by 8 publications

(6 citation statements)

References 26 publications

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“…[31] The risk of developing HF as a complication after MI was 1.5-2 times higher in diabetic patients compared with nondiabetics, irrespective of normal LVEF or previous MI. [32] As DM still remains an independent predictor of HF after MI, left-ventricular diastolic dysfunction has been suggested to be a potential mechanism resulting in elevated left-ventricular filling pressure. [33] In Lamblin's study [33], DM was an independent predictor of cardiovascular death or rehospitalization for HF during 1-year follow up.…”

Section: Discussionmentioning

confidence: 99%

3-year mortality after acute myocardial infarction in patients with different diabetic status

Fojt¹,

Kowalik²,

Gierlotka³

et al. 2021

Polish Archives of Internal Medicine

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Worse prognosis has been observed in patients with myocardial infarction (MI) and previously diagnosed diabetes mellitus (DM), new-onset DM and transient hyperglycemia compared with their non-diabetic counterparts. Many studies concerning treatment results were, however, conducted during the thrombolytic era. Relatively little is known about the outcomes of patients with elevated glucose levels during hospitalization without previous DM diagnosis or patients with new-onset DM. Our study, therefore, enclosed two additional classifications for acute MI patients in regard to glycemia status during hospitalization. We evaluated a nationwide prospective cohort of over 58 thousand MI patients in terms of inhospital complications and long-term outcomes over a three-year period per different carbohydrate disorder type: DM type 1, DM type 2, new-onset DM and transient hyperglycemia. In contrast with previous publications, this article is not only limited to admission glucose levels but includes full glycemia monitoring throughout hospitalization.

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Section: Discussionmentioning

confidence: 99%

3-year mortality after acute myocardial infarction in patients with different diabetic status

Fojt¹,

Kowalik²,

Gierlotka³

et al. 2021

Polish Archives of Internal Medicine

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“…Myocardial perfusion after PCI is of particular importance, as it has been shown to be a powerful predictor of increased infarct size and worse long-term outcomes of patients with STEMI [ 34 ]. Several studies have suggested that patients with DM are less likely to achieve complete myocardial reperfusion assessed with angiography (myocardial blush grade 3 or quantitative myocardial blush) and electrocardiogram (complete ST-segment resolution) after PCI [ 33 , 35 , 36 ]. On the contrary, a larger analysis from the HORIZONS-AMI trial [ 5 ], unlike previous reports, has shown that DM does not affect the achievement of optimal reperfusion after primary PCI.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, successful reperfusion was associated with a decrease in the risk of death by 2/3 in both patients with and without DM, with no interaction between diabetic status and reperfusion success in their effect on 3-year mortality [ 5 ]. More recent analysis by Tomasik et al has confirmed that DM patients with impaired myocardial reperfusion are at higher risk of heart failure and the composite of heart failure and all-cause death at 6 years after STEMI [ 36 ]. These findings may suggest that DM worsens outcomes by several mechanisms, not limited to an impairment of reperfusion.…”

Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus Is Still a Strong Predictor of Periprocedural Outcomes of Primary Percutaneous Coronary Interventions in Patients Presenting with ST-Segment Elevation Myocardial Infarction (from the ORPKI Polish National Registry)

Dziewierz

Zdzierak²,

Malinowski

et al. 2022

JCM

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The impact of diabetes mellitus (DM) on outcomes of patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) was confirmed by several studies. However, it is unclear whether this effect is still present in large groups of unselected patients undergoing up-to-date treatment. Thus, we sought to assess the impact of DM on periprocedural outcomes of primary PCI in STEMI using data from the Polish National Registry of PCI. Data on 150,782 STEMI patients undergoing primary PCI were collected. Of them, 26,360 (17.5%) patients had DM. Patients with DM were higher-risk individuals who experienced longer reperfusion delays and were less likely to have closed infarct-related artery at baseline (TIMI 0 + 1 flow: 73.2% vs. 72.0%; p < 0.0001) and achieve optimal reperfusion after PCI (TIMI 3 flow: 91.8% vs. 88.5%; p < 0.0001). The periprocedural mortality (1.1% vs. 1.9%; p < 0.0001) was higher in patients with DM and DM was identified as an independent predictor of periprocedural death. In conclusion, despite continuous progress in STEMI treatment, DM remains a strong predictor of periprocedural mortality. However, this detrimental effect of DM may be partially explained by the overall higher risk profile of diabetic patients.

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“…AF -atrial fibrillation AMI -acute myocardial infarction AI -atherogenic index AUC -area under the curve AV block -atrioventricular block CAD -coronary artery disease CTRP3 -C1q/tumour necrosis factor -related protein 3 CVD -cardiovascular disease DM -diabetes mellitus EF -ejection fraction HDL -high-density lipoprotein HF -heart failure LA -left atrium LDL -low-density lipoprotein LV -left ventricular LVA -left ventricular aneurysm MI -myocardial infarction PCI -percutaneous coronary intervention ROC -receiver operating characteristic STEMI -ST-elevation myocardial infarction TC -total cholesterol TG -triglyceride VLDL -very low-density lipoprotein ST-elevation myocardial infarction (STEMI) was increased in the presence of type 2 DM and diminished myocardial perfusion 7 . As concluded by Hashmi et al 8 , there wasn't any significant effect of various stratified confounder variables such as age, sex, diabetes, hypertension, smoking, dyslipidemia and duration of presentation after MI on the incidence of complete atrioventricular (AV) block, as it remained the same in all these groups.…”

Section: List Of Abbreviationsmentioning

confidence: 99%

"A Model for Predicting Late Complications of Myocardial Infarction in Patients With Type 2 Diabetes Mellitus"

Koteliukh¹

2022

Arch Balk Med Union

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Modèle de prédiction des complications tardives de l'infarctus du myocarde chez les patients avec diabète de type 2Introduction. Les complications tardives de l'infarctus du myocarde (IDM) constituent l'une des principales causes de ré hospitalisation et de mortalité parmi les patients avec diabète de type 2. L'objectif de l'étude était de prévoir le développement des complications tardives de l'IDM chez les patients avec diabète de type 2 ce qui a permis d'améliorer les méthodes diagnostiques chez cette cohorte de patients. Matériel et méthodes. Le total de 109 patients qui ont développé un diabète de type 2 après avoir subi un IDM, a été divisé en deux groupes : un groupe expérimental (n = 74) et un groupe témoin (n = 35). La détermination de l'adropine et C1q/Protéine 3 induite par le facteur de nécrose tumorale (CTRP3) a été réalisée au moyen de la méthode de dosage immuno-enzymatique. Le modèle de prédiction des complications tardives de l'IDM a été évalué en utilisant la régression logistique binaire.

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Effect of Diabetes Mellitus and Left Ventricular Perfusion on Frequency of Development of Heart Failure and/or All-cause Mortality Late After Acute Myocardial Infarction

Cited by 8 publications

References 26 publications

3-year mortality after acute myocardial infarction in patients with different diabetic status

3-year mortality after acute myocardial infarction in patients with different diabetic status

Diabetes Mellitus Is Still a Strong Predictor of Periprocedural Outcomes of Primary Percutaneous Coronary Interventions in Patients Presenting with ST-Segment Elevation Myocardial Infarction (from the ORPKI Polish National Registry)

"A Model for Predicting Late Complications of Myocardial Infarction in Patients With Type 2 Diabetes Mellitus"

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