Effect of diabetic retinopathy on retinal nerve fiber layer thickness

El-Hifnawy, Mohammad A.M.; Sabry, Kareem M; Gomaa, A.; Hassan, Tamer

doi:10.4103/1110-9173.195262

Cited by 9 publications

(4 citation statements)

References 3 publications

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“…The mean RNFL thickness was 101.43 ± 8.63 um with maximum thickness in the inferior quadrant. El-Hifnawy et al [24, 25] collected normative MT and RNFL thickness data in the Egyptian population, the mean CST was 262.70 ± 19.64 μm and the mean NFLT was 101.74 ± 10.05 μm. The mean MT values were significantly greater in men than in women and were found to be less than those seen in the studies published previously on Caucasians using Spectralis SD-OCT.…”

Section: Discussionmentioning

confidence: 99%

The effect of oral contraceptive pills on the macula, the retinal nerve fiber layer, the ganglion cell layer and the choroidal thickness

Shaaban

2019

BMC Ophthalmol

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BackgrounTo evaluate the effect of oral contraceptive pills (OCP) on the macula, the retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), and the choroidal thickness (CT).MethodsIn this prospective observational cross-sectional study, 60 eyes of 30 healthy women taking monophasic OCP (0.03 mg ethinylestradiol and 0.15 mg levonorgestrel) for contraception for at least 1 year were compared with 60 eyes of a control group of 30 healthy women who were not taking any OCP. Spectral-Domain Optical Coherence Tomography (SD-OCT) was used to evaluate the macula, the RNFL, the GCL, and the CT. Measurements were taken in the follicular phase (day 3) of the last menstrual cycle in all women. The body mass index (BMI) scores of all participants were also recorded.ResultsNo disparity in terms of age and BMI between both groups was observed (p = 0.444, p = 0.074, respectively). All the macular parameters measurements were considerably lower in the OCP group compared to the control group (p < 0.001). Also, the RNFL thickness, the GCL thickness, and the CT were all significantly thinner in the OCP group (p < 0.001).ConclusionsThe use of OCP can cause significant changes in the retina and choroid thickness over 1 year period. The women who are using OCP for a longer duration could have some eye problems. OCT should be routinely done for follow up. Further long term studies are required, using different preparations of OCP. It is important to find out when this thickness alterations can be clinically significant or symptomatic and if these changes are reversible or not.

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Section: Discussionmentioning

confidence: 99%

The effect of oral contraceptive pills on the macula, the retinal nerve fiber layer, the ganglion cell layer and the choroidal thickness

Shaaban

2019

BMC Ophthalmol

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“…El-Hifnawy et al, 23 Normal:20 Diabetic:20 Diabetic retinopathy:30 47.80±10.47 52.90±5.11 52.33±8.82…”

Section: Oct Resultsmentioning

confidence: 98%

“…The global, superior, and temporal retinal nerve fiber layer thickness in diabetic patients without diabetic retinopathy was significantly lower than that of control group and that of patients with non-proliferative retinopathy. 23 Park et al, 24 Normal:40 Diabetic:37 Diabetic retinopathy:89 64.3±6.7 66.2±7.2 65.8±4.9…”

Section: Alexandria Main University Hospitalmentioning

confidence: 99%

Linkage of diabetic retinopathy with blood antioxidants and gut microbiota in type two diabetes mellitus Saudi patients

Fahmy

2024

AOVS

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Background: The retina is a light-sensitive nerve layer located at the back of the eye that creates images of objects. These cells kept alive by getting oxygen and nutrients from tiny blood vessels in the eye. Retinopathy is a disease of the retina that is more prevalent in type 2 diabetes mellitus patients. Diabetic retinopathy is a leading cause of blindness because hyperglycemia weakens retinal capillaries, resulting in leakage of blood into the surrounding space. This bleeding can result in formation of scar tissue, which can cause traction retinal detachment and maculopathy. The development of a panel of blood biomarkers to monitor diabetic retinopathies is essential for both diagnosis and prognosis. Proteomics as a powerful tool for the analysis of complex mixtures of proteins and the identification of biomarkers can be of great importance. Purpose: To detect early nerve fiber layer changes around macula and optic disc in diabetic patients, and to correlate diabetic retinopathy with blood antioxidants and gut microbiota in T2DM in Saudi patients. Materials and Methods: In this cross-sectional case-control study, a total of 77 eyes of 39 subjects aged 40-60 years who did not have any history of eye injuries or eye diseases affecting fundus viewing, were recruited from King Saud University Campus and the department of ophthalmology in King Abdul Aziz university hospital in Riyadh. All subjects underwent full ophthalmic examination including Peripapillary retinal nerve fiber layer thickness and macular profile, Proteomic approach of collected overnight fasting plasma and Microbial stool examination. Results: The nerve fiber layer thickness around the optic disc was measured for all groups, and there was no statistically significant difference in all quadrants between groups. The total retinal thickness at the macular area was different among all groups and tends to increase in group 3 due to diabetic retinopathy. The macular thickness in the 4 quadrants revealed no statistical difference except in the inferior quadrant. Glutathione S transferase and lipid peroxides showed no significant difference between the three studied groups; vitamin C and Glutathione were surprisingly higher in controlled diabetic patients relative to controls. Moreover, over growth of bacteroids participated to the evolution of retinopathy in diabetic patients. Conclusion: As hyperglycemia and oxidative stress are implicated in the pathogenesis of diabetic retinopathy, the present study certified that the progressive damage can be delayed in controlled type 2 diabetic patients using different treatment modalities that subside oxidative stress.

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“…The study concluded that neurodegeneration is a significant component in the early stages of diabetic retinopathy. 71 El-Hifnawy et al 73 studied RNFL in diabetics without retinopathy or macular oedema and also found thinning of RNFL, suggesting that early retinal neurodegeneration can occur before vascular changes are observed. Thus, a similar mechanism for changes in retinal hypoxia and ganglion cell function, resulting in inner retinal dysfunction, is displayed in diabetics, strengthening the case for reduced perfusion and blood flow and retinal effects; and this may also help make a case for systemic hypotension and possible retinal involvement.…”

Section: The Utility Of Gcc and Rnfl Evaluation In Nonglaucomatous Conditions With Reduced Blood Flowmentioning

confidence: 99%

A review of ocular perfusion pressure and retinal thickness: A case for the role of systemic hypotension in glaucoma

Vawda

Munsamy

2021

African Vision and Eye Health

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Background: Ocular perfusion pressure (OPP) is defined as blood pressure (BP) minus intraocular pressure (IOP). Low OPP may result in decreased ocular blood flow (OBF) and oxygen to the optic nerve head (ONH) and retina.Aim: To review the role of systemic hypotension and similar conditions in OPP and its influence on retinal nerve fibre layer (RNFL) thickness and the ganglion cell complex (GCC).Method: A literature search was conducted using the following search terms: ‘systemic hypotension’; ‘glaucoma’; ‘retinal nerve fibre layer’; ‘optic nerve’; ‘ocular blood flow’ and ‘ocular perfusion pressure’.Results: The Los Angeles Eye Study and Barbados Eye Study found that decreased OPP and BP increased the risk of glaucoma development by up to six times. Reduced retinal perfusion with resultant thinning of the RNFL in conditions with a similar mechanism, such as obstructive sleep apnoea syndrome, has indicated the importance of reduced OPP in retinal thickness. In the absence of any study directly showing the effect of systemic hypotension on OPP and retinal thickness, a working hypothesis proposes that reduced BP with or without normal-to-raised IOP will reduce OPP. The reduced OPP and OBF in those with systemic hypotension may result in oxidative stress and hypoxia which may then cause retinal ganglion cell death and the resultant retinal thinning.Conclusion: The increased risk of glaucoma development and progression relating to decreased BP and OPP has been proven to be of importance. Monitoring patients with systemic hypotension and evaluating the macula, ONH RNFL and GCC thickness may alert clinicians to possible glaucomatous changes.

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Effect of diabetic retinopathy on retinal nerve fiber layer thickness

Cited by 9 publications

References 3 publications

The effect of oral contraceptive pills on the macula, the retinal nerve fiber layer, the ganglion cell layer and the choroidal thickness

The effect of oral contraceptive pills on the macula, the retinal nerve fiber layer, the ganglion cell layer and the choroidal thickness

Linkage of diabetic retinopathy with blood antioxidants and gut microbiota in type two diabetes mellitus Saudi patients

A review of ocular perfusion pressure and retinal thickness: A case for the role of systemic hypotension in glaucoma

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