Effect of diaspirin cross‐linked haemoglobin (DCLHb™) on mean arterial pressure during cardiopulmonary bypass in swine

Ferrera, René; Hadour, Guylaine; Chiari, Pascal; Montagna, P.; Jegaden, Olivier; Burhop, Kenneth E.; Lehot, Jean‐Jacques

doi:10.1046/j.1365-3148.2002.00391.x

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…9 In animal studies, the administration of increasing doses of cross-linked Hb during cardiopulmonary bypass surgery induced an increase in mean arterial pressure. 10 Furthermore, it has also been reported that free Hb induces vasoconstriction because of NO scavenging, limiting the NO availability for vascular smooth muscle cells, which elevates the blood pressure. 11,12 The presumed association between Hb level and blood pressure has been mainly investigated in patients but never in a healthy set of persons.…”

mentioning

confidence: 99%

Hemoglobin Level Is Positively Associated With Blood Pressure in a Large Cohort of Healthy Individuals

Atsma

Veldhuizen²,

Kort³

et al. 2012

Hypertension

130

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Abstract-It has been hypothesized that an increased hemoglobin level elevates blood pressure. The present study investigated the association between hemoglobin level and systolic blood pressure and diastolic blood pressure in healthy persons. The study population was composed of 101 377 whole blood and plasma donors, who made 691 107 visits to the blood bank. At each visit, hemoglobin level and blood pressure were measured as part of the standard procedure before a blood donation. We used repeated measurement analysis to analyze the data. We used generalized estimating equation models to assess the between-person effect and linear mixed models to assess the within-person effect. All of the analyses were done separately for men and women. In the study population, 50% were men. The mean age in men was 49.3 years (±12.5 years), and in women it was 42.4 years (±13.7 years). Hemoglobin level was positively associated with both systolic and diastolic blood pressures. With respect to the between-person effect, regression coefficients for systolic blood pressure were 1.3 mm Hg per millimole per liter increase in hemoglobin level for men and 1.8 mm Hg per millimole per liter increase in hemoglobin level for women. With respect to the within-person effect, regression coefficients for systolic blood pressure were 0.7 mm Hg and 0.9 mm Hg per millimole per liter increase in hemoglobin level, for men and women, respectively. For diastolic blood pressure, results were comparable. The results show that hemoglobin level is positively associated with both systolic and diastolic blood pressures in healthy individuals. We observed consistent effects between persons but also within persons.

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mentioning

confidence: 99%

Hemoglobin Level Is Positively Associated With Blood Pressure in a Large Cohort of Healthy Individuals

Atsma

Veldhuizen²,

Kort³

et al. 2012

Hypertension

130

View full text Add to dashboard Cite

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“…Hemoglobin level is also associated with arterial stiffness 9 . In animal studies, it is also demonstrated that mean arterial pressure increases with increasing the infusion rate of cross-linked hemoglobin during cardiopulmonary bypass surgery 10 . Besides, it is suggested that the injection of erythropoietin for the treatment of anemia in patients with end-stage renal disease is associated with elevated blood pressure 11 .…”

Section: Association Between Hemoglobin Variability and Incidence Of mentioning

confidence: 98%

Association between hemoglobin variability and incidence of hypertension over 40 years: a Korean national cohort study

Son

Park

et al. 2020

Sci Rep

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Data source and study population. This study was approved by the Institutional Review Board of Gwangju Institute of Science and Technology (20190902-EX-02-02) and was performed based on the Declaration of Helsinki. Since the NHIS-Heals data was provided anonymously according to strict confidentiality guidelines, this study was exempted from receiving the subject's informed consent by Institutional Review Board of Gwangju Institute of Science and Technology. The NHIS database is registered with 98% of Koreans and includes all insurance claims. We analyzed the data using the health screening cohort, which was extracted from a random sampling of approximately 10% of a total 5 million people over 40 years received a health screening in 2002 or 2003. The NHIS provided a mandatory biennial general health screening for people over 40 years. The NHIS-HealS database includes demographic factors (sex, age, and income), hospital utilization (information about the use of medical facilities, admission date, and discharge date), and biennial health screening (height, weight, blood pressure, and blood tests). More information about the database can be found on the relevant website 13. The NHIS-HealS database has been used in many epidemiological studies and its validity is demonstrated elsewhere 14. This study was conducted with adults (age ≥ 40 years) who visited the health screening in 2006 or 2007 (index year) and had at least 3 health screenings from 2002 to 2007. Subjects meeting the criteria for the diagnosis of hypertension before the index year were excluded. Subjects with one or more missing values were also excluded.

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Reviving Artificial Blood: Meeting the Challenge of Dealing with NO Scavenging by Hemoglobin

Lui¹,

Kluger²

2010

ChemBioChem

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Effect of diaspirin cross‐linked haemoglobin (DCLHb™) on mean arterial pressure during cardiopulmonary bypass in swine

Cited by 5 publications

References 17 publications

Hemoglobin Level Is Positively Associated With Blood Pressure in a Large Cohort of Healthy Individuals

Hemoglobin Level Is Positively Associated With Blood Pressure in a Large Cohort of Healthy Individuals

Association between hemoglobin variability and incidence of hypertension over 40 years: a Korean national cohort study

Reviving Artificial Blood: Meeting the Challenge of Dealing with NO Scavenging by Hemoglobin

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